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    KDR kinase insert domain receptor [ Homo sapiens (human) ]

    Gene ID: 3791, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    High expression of DEC2 distinguishes chondroblastic osteosarcoma and promotes tumour growth by activating the VEGFC/VEGFR2 signalling pathway.

    High expression of DEC2 distinguishes chondroblastic osteosarcoma and promotes tumour growth by activating the VEGFC/VEGFR2 signalling pathway.
    Tuerxun M, Zheng X, Xu J, Yang Q, Yuan T, Zhang C, Zhou S., Free PMC Article

    10/30/2024
    The KDR Gene rs2071559 and the VEGF Gene rs6921438 May Be Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus.

    The KDR Gene rs2071559 and the VEGF Gene rs6921438 May Be Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus.
    Nussdorfer P, Petrovič D, Alibegović A, Cilenšek I, Petrovič D., Free PMC Article

    09/20/2024
    Vasorin promotes endothelial differentiation of glioma stem cells via stimulating the transcription of VEGFR2.

    Vasorin promotes endothelial differentiation of glioma stem cells via stimulating the transcription of VEGFR2.
    Qin Z, Zhong Y, Li P, Ma Z, Kang H, Huang Y, Zhong Y, Wang L.

    09/4/2024
    Mutation in the Kinase Domain Alters the VEGFR2 Membrane Dynamics.

    Mutation in the Kinase Domain Alters the VEGFR2 Membrane Dynamics.
    Corsini M, Ravelli C, Grillo E, Domenichini M, Mitola S., Free PMC Article

    08/29/2024
    Prognostic Significance of Plasma VEGFA and VEGFR2 in Acute Ischemic Stroke-a Prospective Cohort Study.

    Prognostic Significance of Plasma VEGFA and VEGFR2 in Acute Ischemic Stroke-a Prospective Cohort Study.
    Hu Y, Huang S, Shen T, Wang R, Geng M, Wang Y, Zheng Y, Luo Y, Li S.

    08/23/2024
    Lack of VEGFA/KDR Signaling in Conventional Renal Cell Carcinoma Explains the Low Efficacy of Target Therapy and Frequent Adverse Events.

    Lack of VEGFA/KDR Signaling in Conventional Renal Cell Carcinoma Explains the Low Efficacy of Target Therapy and Frequent Adverse Events.
    Peterfi L, Yusenko MV, Kovacs G, Beothe T., Free PMC Article

    08/9/2024
    Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.

    Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.
    Tsumuraya H, Mimura K, Nakajima S, Hanayama H, Matsuishi A, Okayama H, Fukai S, Ito M, Ashizawa M, Chida S, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, Kono K.

    07/16/2024
    The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein.

    The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein.
    Mohanty S, Suklabaidya S, Lavorgna A, Ueno T, Fujisawa JI, Ngouth N, Jacobson S, Harhaj EW., Free PMC Article

    07/15/2024
    VEGFR2 blockade inhibits glioblastoma cell proliferation by enhancing mitochondrial biogenesis.

    VEGFR2 blockade inhibits glioblastoma cell proliferation by enhancing mitochondrial biogenesis.
    Guo M, Zhang J, Han J, Hu Y, Ni H, Yuan J, Sun Y, Liu M, Gao L, Liao W, Ma C, Liu Y, Li S, Li N., Free PMC Article

    05/20/2024
    Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor.

    Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor.
    Ho SJ, Chaput D, Sinkey RG, Garces AH, New EP, Okuka M, Sang P, Arlier S, Semerci N, Steffensen TS, Rutherford TJ, Alsina AE, Cai J, Anderson ML, Magness RR, Uversky VN, Cummings DAT, Tsibris JCM., Free PMC Article

    04/24/2024
    Endothelial beta-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.

    Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.
    Chen Z, Lin B, Yao X, Weng J, Liu J, He Q, Song K, Zhou C, Zuo Z, Huang X, Liu Z, Huang Q, Xu Q, Guo X., Free PMC Article

    03/18/2024
    The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients.

    The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients.
    Abdelgalil AA, Monir R, Elmetwally M, Ghattas MH, Bazeed FB, Mesbah NM, Abo-Elmatty DM, Mehanna ET.

    03/4/2024
    Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.

    Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
    Sarabipour S, Kinghorn K, Quigley KM, Kovacs-Kasa A, Annex BH, Bautch VL, Mac Gabhann F., Free PMC Article

    02/21/2024
    VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer.

    VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer.
    Hui K, Dong C, Hu C, Li J, Yan D, Jiang X.

    02/20/2024
    Association of KDR (rs2071559, rs1870377), CFH (rs1061170, rs1410996) genes variants and serum levels with pituitary adenoma.

    Association of KDR (rs2071559, rs1870377), CFH (rs1061170, rs1410996) genes variants and serum levels with pituitary adenoma.
    Bruzaite A, Gedvilaite G, Kriauciuniene L, Liutkeviciene R., Free PMC Article

    02/7/2024
    Association of single nucleotide variants in VEGFA and KDR with the risk and angiogenic features of diffuse large B-cell lymphoma.

    Association of single nucleotide variants in VEGFA and KDR with the risk and angiogenic features of diffuse large B-cell lymphoma.
    Assis-Mendonça GR, Campos LG, Delamain MT, de Brito ABC, Fanelli MF, Soares FA, de Souza CA, Vassallo J, Lima CSP.

    01/30/2024
    Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner.

    Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner.
    Sayın Kocakap DB, Kaygusuz S, Aksoy E, Şahin Ö, Baççıoğlu A, Ekici A, Kalpaklıoğlu AF, Ekici MS, Gül S, Kaçmaz B, Ayaşlıoğlu Açıkgöz E, Alyılmaz Bekmez S, Rouse BT, Azkur AK.

    12/20/2023
    Biomechanical stimulation promotes blood vessel growth despite VEGFR-2 inhibition.

    Biomechanical stimulation promotes blood vessel growth despite VEGFR-2 inhibition.
    Johnson BM, Johnson AM, Heim M, Buckley M, Mortimer B, Berry JL, Sewell-Loftin MK., Free PMC Article

    12/20/2023
    Genetic polymorphisms in VEGFA and VEGFR2 genes associated with coronary heart disease susceptibility and severity.

    Genetic polymorphisms in VEGFA and VEGFR2 genes associated with coronary heart disease susceptibility and severity.
    Hajer F, Hana S, Saoussen C, Abdelhak F, Nadia B, Ameni D, Habib G, Hassen BA, Amel HK.

    11/28/2023
    IL-36gamma Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.

    IL-36γ Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.
    Cho WJ, Elbasiony E, Singh A, Mittal SK, Chauhan SK., Free PMC Article

    11/16/2023
    Endothelial VEGFR2-PLCgamma signaling regulates vascular permeability and antitumor immunity through eNOS/Src.

    Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src.
    Sjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love DT, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L., Free PMC Article

    11/1/2023
    VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial.

    VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial.
    Levallet G, Dubois F, Elie N, Creveuil C, Brosseau S, Danel C, Scherpereel A, Lantuejoul S, Mazières J, Greillier L, Audigier-Valette C, Bergot E, Moro-Sibilot D, Molinier O, Léna H, Monnet I, Morin F, Gounant V, Zalcman G.

    10/26/2023
    PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance.

    PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance.
    Carlotto BS, Trevisan P, Provenzi VO, Soares FP, Rosa RFM, Varella-Garcia M, Zen PRG., Free PMC Article

    09/25/2023
    Mechanism of the HIF-1alpha/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells.

    Mechanism of the HIF-1α/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells.
    Zhang W, Sun L, Gao H, Wang S., Free PMC Article

    09/15/2023
    Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.

    Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.
    Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, Kondo S, Furuhashi A, Hayashi T, Hosokawa Y, Kazaoka Y., Free PMC Article

    09/1/2023
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