| H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1. | H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1.
Tang R, Zhou M, Chen Y, Jiang Z, Fan X, Zhang J, Dong A, Lv L, Mao S, Chen F, Gao G, Min J, Liu K, Yuan K., | 10/31/2024 |
| SetDB1 and Su(var)3-9 are essential for late stages of larval development of Drosophila melanogaster. | SetDB1 and Su(var)3-9 are essential for late stages of larval development of Drosophila melanogaster.
Romanov SE, Shloma VV, Maksimov DA, Koryakov DE. | 12/20/2023 |
| SetDB1 and Su(var)3-9 play non-overlapping roles in somatic cell chromosomes of Drosophila melanogaster. | SetDB1 and Su(var)3-9 play non-overlapping roles in somatic cell chromosomes of Drosophila melanogaster.
Kalashnikova DA, Maksimov DA, Romanov SE, Laktionov PP, Koryakov DE. | 08/7/2021 |
| In ovarian somatic cells, Egg is monoubiquitinated and phosphorylated but only monoubiquitination is required for piRNA-mediated transposon repression. Egg monoubiquitination occurs in the nucleus. Egg has its own nuclear localization signal, and the nuclear import of Egg is Wde-independent. Wde recruits Egg to the chromatin at target gene silencing loci, but their interaction is monoubiquitin-independent. | Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.
Osumi K, Sato K, Murano K, Siomi H, Siomi MC., Free PMC Article | 05/23/2020 |
| SETDB1 is required for chromosome binding of SU(VAR)3-9. | Binding of SU(VAR)3-9 Partially Depends on SETDB1 in the Chromosomes of Drosophila melanogaster.
Maksimov DA, Koryakov DE., Free PMC Article | 05/9/2020 |
| We show that Egg plays diverse roles in particular piRNA pathway gene expression, some long non-coding RNA expression, apoptosis-related gene regulation, and Decapentaplegic (Dpp) signaling during Drosophila oogenesis. | Identification of target genes regulated by the Drosophila histone methyltransferase Eggless reveals a role of Decapentaplegic in apoptotic signaling.
Kang I, Choi Y, Jung S, Lim JY, Lee D, Gupta S, Moon W, Shin C., Free PMC Article | 10/12/2019 |
| a major requirement for the methyltransferase Eggless/SetDB1 in the establishment of heterochromatin | Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila.
Seller CA, Cho CY, O'Farrell PH., Free PMC Article | 04/20/2019 |
| Data show that histone-lysine N-methyltransferase (SETDB1) loss blocks germ cell differentiation. | The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells.
Smolko AE, Shapiro-Kulnane L, Salz HK., Free PMC Article | 01/12/2019 |
| Study identified a H3K9 methyltransferase, SETDB1/eggless, a Drosophila homologue of the mammalian SETDB1, which confers the robustness for the precise determination of bristle number. | Drosophila SETDB1 and caspase cooperatively fine-tune cell fate determination of sensory organ precursor.
Shinoda N, Obata F, Zhang L, Miura M. | 12/17/2016 |
| dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche. | Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila.
Upadhyay M, Martino Cortez Y, Wong-Deyrup S, Tavares L, Schowalter S, Flora P, Hill C, Nasrallah MA, Chittur S, Rangan P., Free PMC Article | 08/13/2016 |
| Mosaic analysis also reveals that the early egg chamber budding defects in egg- ovaries are due to an intrinsic requirement for egg in follicle stem cells and their descendents | Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1.
Clough E, Tedeschi T, Hazelrigg T., Free PMC Article | 07/12/2014 |
| The results showed that on chromosome 4, Su(var)3-9, SETDB1 and HP1a target the same genes. | HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster.
Lundberg LE, Stenberg P, Larsson J., Free PMC Article | 06/29/2013 |
| dSet1 is responsible for the bulk of H3K4 di- and trimethylation throughout Drosophila development. | dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development.
Hallson G, Hollebakken RE, Li T, Syrzycka M, Kim I, Cotsworth S, Fitzpatrick KA, Sinclair DA, Honda BM., Free PMC Article | 05/12/2012 |
| this study has revealed the essential roles of Eggless (Egg), a H3K9 methyltransferase in controlling stem cell maintenance and differentiation through distinct mechanisms. | Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation.
Wang X, Pan L, Wang S, Zhou J, McDowell W, Park J, Haug J, Staehling K, Tang H, Xie T., Free PMC Article | 03/24/2012 |
| Together with Egg, Wde localizes to euchromatin, is enriched on chromosome 4, and binds to the Painting of fourth (POF) protein. | Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.
Koch CM, Honemann-Capito M, Egger-Adam D, Wodarz A., Free PMC Article | 01/21/2010 |
| The genetic interactions between dSETDB1 and Su(var)3-9 mutations emphasize the importance of maintaining the activities of these histone methyltransferases in balance for normal genome function. | Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.
Brower-Toland B, Riddle NC, Jiang H, Huisinga KL, Elgin SC., Free PMC Article | 01/21/2010 |
| results indicate that dSETDB1 and SU(VAR)3-9 act together with distinct roles during oogenesis, with dsetdb1 being of particular importance due to its germline stem cell-specific function and more severe mutant phenotype | dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster.
Yoon J, Lee KS, Park JS, Yu K, Paik SG, Kang YK., Free PMC Article | 01/21/2010 |
| egg is required in the ovary for trimethylation of histone H3 at its K9 residue. | Histone methylation is required for oogenesis in Drosophila.
Clough E, Moon W, Wang S, Smith K, Hazelrigg T. | 01/21/2010 |