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    KIR2DL2 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 [ Homo sapiens (human) ]

    Gene ID: 3803, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.

    Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.
    Shiravani Z, Mirshekari K, Larki MH, Shafiee N, Haghshenas MR, Ghaderi A, Fattahi MJ.

    04/17/2024
    The KIR2DL2/HLA-C1C1 Gene Pairing Is Associated With an Increased Risk of SARS-CoV-2 Infection.

    The KIR2DL2/HLA-C1C1 Gene Pairing Is Associated With an Increased Risk of SARS-CoV-2 Infection.
    Hu S, Shao Z, Ni W, Sun P, Qiao J, Wan H, Huang Y, Liu X, Zhai H, Xiao M, Sun B., Free PMC Article

    08/6/2022
    Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma.

    Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma.
    Jiang P, Nolte IM, Hepkema BG, Stulp M, van den Berg A, Diepstra A., Free PMC Article

    03/19/2022
    Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.

    Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.
    Palamarchuk AI, Alekseeva NA, Streltsova MA, Ustiuzhanina MO, Kobyzeva PA, Kust SA, Grechikhina MV, Boyko AA, Shustova OA, Sapozhnikov AM, Kovalenko EI., Free PMC Article

    01/15/2022
    Inhibitory KIR2DL2 Gene: Risk for Deep Endometriosis in Euro-descendants.

    Inhibitory KIR2DL2 Gene: Risk for Deep Endometriosis in Euro-descendants.
    Marin MLC, Coelho V, Visentainer JEL, Alves HV, Köhler KF, Rached MR, Abrão MS, Kalil J.

    11/27/2021
    Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.

    Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.
    Ahn R, Vukcevic D, Motyer A, Nititham J, Squire DM, Hollenbach JA, Norman PJ, Ellinghaus E, Nair RP, Tsoi LC, Oksenberg J, Foerster J, Lieb W, Weidinger S, Franke A, Elder JT, Jorgenson E, Leslie S, Liao W., Free PMC Article

    10/30/2021
    Decreased HLA-C1 alleles in couples of KIR2DL2 positive women with recurrent pregnancy loss.

    Decreased HLA-C1 alleles in couples of KIR2DL2 positive women with recurrent pregnancy loss.
    Yang X, Yang E, Wang WJ, He Q, Jubiz G, Katukurundage D, Dambaeva S, Beaman K, Kwak-Kim J.

    09/25/2021
    Clinical and histopathological changes in different KIR gene profiles in chronic HCV Romanian patients.

    Clinical and histopathological changes in different KIR gene profiles in chronic HCV Romanian patients.
    Ursu LD, Calenic B, Diculescu M, Dima A, Stoian IT, Constantinescu I.

    07/10/2021
    KIR and HLA-C genes in male infertility.

    KIR and HLA-C genes in male infertility.
    Wilczyńska K, Radwan P, Krasiński R, Radwan M, Wilczyński JR, Malinowski A, Barcz E, Nowak I., Free PMC Article

    05/8/2021
    Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.

    Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.
    Moradi S, Stankovic S, O'Connor GM, Pymm P, MacLachlan BJ, Faoro C, Retière C, Sullivan LC, Saunders PM, Widjaja J, Cox-Livingstone S, Rossjohn J, Brooks AG, Vivian JP., Free PMC Article

    04/24/2021
    Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.

    Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.
    Auer ED, Tong HV, Amorim LM, Malheiros D, Hoan NX, Issler HC, Petzl-Erler ML, Beltrame MH, Boldt ABW, Toan NL, Song LH, Velavan TP, Augusto DG.

    10/3/2020
    In head and neck squamous cell carcinoma (HNSCC), KIR2DL2 is positively while KIR2DS4 is negatively associated with advanced stage. The higher proportion of LNM in carriers of KIR2DL2 and carriers of 5 iKIRs, suggested that inhibitory KIRs are associated with metastatic risk.

    KIR2DS4, KIR2DL2, and KIR2DS4del are linked with basaloid tumors, lymph node metastasis, advanced stage and metastatic risk in head and neck squamous cell carcinoma.
    Barani S, Khademi B, Ghaderi A.

    07/18/2020
    The combination KIR2DS2/KIR2DL2/C1 correlated with severe Alzheimer's Disease status and an increased susceptibility to HHV-6A infection.

    KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: Implication for the Role of Herpesvirus Infections.
    Rizzo R, Bortolotti D, Gentili V, Rotola A, Bolzani S, Caselli E, Tola MR, Di Luca D.

    05/30/2020
    The presence of KIR2DL1 on NKG2C(+) NK cells led to significantly larger clonal expansions than the cenB-encoded KIR2DL2.

    KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals.
    Manser AR, Scherenschlich N, Thöns C, Hengel H, Timm J, Uhrberg M.

    05/23/2020
    KIR2DL2 variant is associated with low viral load in the Zimbabwean adults with chronic HIV infection.

    HLA-C*18:01 and KIR2DL2+C1 genetic variants are associated with low viral load in cART naïve HIV-infected adult Zimbabweans.
    Mhandire K, Tshabalala M, Zijenah LS, Mlambo T, Mhandire DZ, Musarurwa C, Duri K, Matarira HT, Dandara C, Rowland-Jones SL, Stray-Pedersen B.

    04/11/2020
    Our finding suggests that presentation of specific LASV epitopes by HLA-C alleles to the inhibitory KIR2DL2 receptor on NK cells could potentially prevent the killing of infected cells and provides insights into the mechanisms by which LASV can escape NK-cell-mediated immune pressure.

    HLA-C-restricted viral epitopes are associated with an escape mechanism from KIR2DL2(+) NK cells in Lassa virus infection.
    Wauquier N, Petitdemange C, Tarantino N, Maucourant C, Coomber M, Lungay V, Bangura J, Debré P, Vieillard V., Free PMC Article

    06/29/2019
    The multivariate analysis revealed that the lack of KIR2DS2 (p = 0.035), the presence of KIR2DL3 (p = 0.075), and the presence of KIR2DL2HLA-C1 (p = 0.044) were risk factors for posttransplant cytomegalovirus infection.

    Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
    Deborska-Materkowska D, Perkowska-Ptasinska A, Sadowska-Jakubowicz A, Gozdowska J, Ciszek M, Pazik J, Ostaszewska A, Kosieradzki M, Nowak J, Durlik M., Free PMC Article

    06/8/2019
    The results suggest that KIR2DL2 and 2DS4del could have a risk role in the development of Systemic Sclerosis, but not with clinical manifestations.

    KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico.
    Machado-Sulbaran AC, Ramírez-Dueñas MG, Navarro-Zarza JE, Muñoz-Valle JF, Mendoza-Carrera F, Baños-Hernández CJ, Parra-Rojas I, Montoya-Buelna M, Sánchez-Hernández PE., Free PMC Article

    04/27/2019
    Killer cell immunoglobulin like receptor two (KIR2DL2) shows a risk association with Chinese Han hepatitis C virus-1b (HCV-1b) patients not responding to the combination therapy of pegylated alpha interferon (PEG-IFN) with ribavirin (RBV).

    KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China.
    Hu S, Yuan F, Feng L, Zheng F, Gong F, Huang H, Sun B., Free PMC Article

    11/24/2018
    KIR2DL2/HLA-C( *)12:02 and KIR2DL2/HLA-C( *)14:03 compound genotypes have protective effects on control of HIV-1.

    HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C(∗)12:02/C(∗)14:03.
    Lin Z, Kuroki K, Kuse N, Sun X, Akahoshi T, Qi Y, Chikata T, Naruto T, Koyanagi M, Murakoshi H, Gatanaga H, Oka S, Carrington M, Maenaka K, Takiguchi M., Free PMC Article

    11/25/2017
    KIR2DL2 gene polymorphism is associated with HIV-1 infection.

    The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the Polish population.
    Zwolińska K, Błachowicz O, Tomczyk T, Knysz B, Gąsiorowski J, Zalewska M, Orzechowska BU, Sochocka M, Piasecki E., Free PMC Article

    05/13/2017
    association between KIR2DS2 and the response to methotrexate (MTX), moreover, the combination KIR2DL2+/KIR2DS2+ was more frequent in responders to MTX (p = 0.043).

    KIR2DL2 and KIR2DS2 as genetic markers to the methotrexate response in rheumatoid arthritis patients.
    Velarde-de la Cruz EE, Sánchez-Hernández PE, Muñoz-Valle JF, Palafox-Sánchez CA, Ramírez-de Los Santos S, Graciano-Machuca O, García-Iglesias T, Montoya-Buelna M, Ramírez-Dueñas MG.

    03/25/2017
    KIR2DL2/KIR2DL3-glutamate(35) alleles are functionally stronger than -glutamine(35) alleles.

    KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.
    Bari R, Thapa R, Bao J, Li Y, Zheng J, Leung W., Free PMC Article

    02/4/2017
    KIR2DL2/2DS2-C1C1 genotype is associated with type 1 diabetes in Saudi children

    Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).
    Osman AE, Eltayeb-ELSheikh N, Mubasher M, Al Harthi H, Alharbi S, Hamza MA, ElGhazali G.

    11/12/2016
    genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2, KIR2DS4, KIR2DL3) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes.

    Killer immunoglobulin receptor genes and their HLA-C ligand are associated with Type 1 diabetes in an Eastern Indian population.
    Sanjeevi S, Sun C, Kanungo A, Sanjeevi CB.

    10/22/2016
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