| Neurofilament Protein as a Potential Biomarker of Axonal Degeneration in Experimental Autoimmune Encephalomyelitis. | Neurofilament Protein as a Potential Biomarker of Axonal Degeneration in Experimental Autoimmune Encephalomyelitis.
Wang P, Jiang LL, Wang C, Zhu Z, Lai C. | 03/20/2021 |
| These findings indicate that NEFH is expressed in podocytes during the disease course and that it prevents the reduction in synaptopodin expression and detachment of podocytes. | Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment.
Wang J, Hidaka T, Sasaki Y, Tanaka E, Takagi M, Shibata T, Kubo A, Trejo JAO, Wang L, Asanuma K, Tomino Y., Free PMC Article | 11/2/2019 |
| The abundance of dural afferent neurons expressing NF200 in adult mice. | Quantitative Analysis of Mouse Dural Afferent Neurons Expressing TRPM8, VGLUT3, and NF200.
Ren L, Chang MJ, Zhang Z, Dhaka A, Guo Z, Cao YQ., Free PMC Article | 03/30/2019 |
| Data indicate the presence of a HuD - BDNF - NF-H pathway activated as a regenerative response to the axonal damage induced by antiretroviral treatment to counteract the antiretroviral neurotoxicity. | Increase of neurofilament-H protein in sensory neurons in antiretroviral neuropathy: Evidence for a neuroprotective response mediated by the RNA-binding protein HuD.
Sanna MD, Peroni D, Mello T, Ghelardini C, Quattrone A, Galeotti N. | 12/30/2017 |
| Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200, and calbindin in mouse motor neurons. | Changes in the Neurochemical Composition of Motor Neurons of the Spinal Cord in Mice under Conditions of Space Flight.
Porseva VV, Shilkin VV, Strelkov AA, Krasnov IB, Masliukov PM. | 02/18/2017 |
| Data conclude that NF-H and NF-M C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons. | The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network.
Rao MV, Yuan A, Campbell J, Kumar A, Nixon RA., Free PMC Article | 03/9/2013 |
| plasma NfH levels closely reflect later stages of disease progression and therapeutic response in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis | Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS.
Lu CH, Petzold A, Kalmar B, Dick J, Malaspina A, Greensmith L., Free PMC Article | 01/26/2013 |
| NFH expression reveals an exquisite level of Cb stripe complexity that respects the transverse zone divisions and delineates an intricately patterned target field for Cb afferents. | Neurofilament heavy chain expression reveals a unique parasagittal stripe topography in the mouse cerebellum.
Demilly A, Reeber SL, Gebre SA, Sillitoe RV. | 01/14/2012 |
| If expression of neurofilament heavy is developmentally delayed, the neurofilament network is established in a distal to proximal gradient, perhaps to allow distal axonal segments to develop prior to proximal segments. | Distal to proximal development of peripheral nerves requires the expression of neurofilament heavy.
Shen H, Barry DM, Garcia ML., Free PMC Article | 05/28/2011 |
| results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H and NF-M | Hypophosphorylation of NF-H and NF-M subunits of neurofilaments and the associated decrease in KSPXK kinase activity in the sciatic nerves of swiss white mice inoculated in the foot pad with mycobacterium leprae.
Save MP, Shetty VP, Shetty KT. | 04/12/2010 |
| RE1 silencing transcription factor (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin, NF-H and NF-M genes | RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes.
Ching GY, Liem RK., Free PMC Article | 01/21/2010 |
| We have validated the serum pNF-H assay as an unbiased measurement of axonal injury in EAE, facilitating rapid screening of potential neuroprotective therapies in this model. | Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis.
Gresle MM, Shaw G, Jarrott B, Alexandrou EN, Friedhuber A, Kilpatrick TJ, Butzkueven H. | 01/21/2010 |
| We found an amacrine cell type that was immunolabeled with an antibody against SMI32, a non-phosphorylated epitope on neurofilament proteins of high molecular weight, in the mouse retina. | Identification and characterization of SMI32-immunoreactive amacrine cells in the mouse retina.
Lim EJ, Kim IB, Oh SJ, Chun MH. | 01/21/2010 |
| Alpha-internexin coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M alone or together with NF-H in mice reduces alpha-internexin transport & content in axons throughout the CNS. | Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.
Yuan A, Rao MV, Sasaki T, Chen Y, Kumar A, Veeranna, Liem RK, Eyer J, Peterson AC, Julien JP, Nixon RA., Free PMC Article | 01/21/2010 |
| NF-H regulates the association of NFs with kinesin. Phosphorylation of NF-H dissociates NFs from kinesin and provides a mechanism by which NF-H phosphorylation can contribute to the slowing of NF axonal transport. | The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: inhibition by phosphorylation of the high molecular weight subunit.
Jung C, Lee S, Ortiz D, Zhu Q, Julien JP, Shea TB. | 01/21/2010 |
| Overexpression of peripherin in mice deficient for neurofilament light (NF-L) subunits induced a progressive ALS-like spinal motor neuron degeneration prevented by simultaneous overexpression of NF-H | Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins.
Beaulieu JM, Julien JP. | 01/21/2010 |