| Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. | Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V., Free PMC Article | 03/13/2024 |
| Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. | Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity.
Zhao H, Liu Y, Wang L, Jin G, Zhao X, Xu J, Zhang G, Ma Y, Yin N, Peng M. | 02/19/2022 |
| Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses. | Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V., Free PMC Article | 01/1/2022 |
| Roquin-1 Regulates Macrophage Immune Response and Participates in Hepatic Ischemia-Reperfusion Injury. | Roquin-1 Regulates Macrophage Immune Response and Participates in Hepatic Ischemia-Reperfusion Injury.
Zheng L, Ling W, Zhu D, Li Z, Kong L., Free PMC Article | 09/12/2020 |
| In mice, loss of post-transcriptional regulation by Roquin-1 results in increased expression of ICOS and Ox40 in T cells. In the absence of Roquin-1, mice develop an immunopathology characterized by the expansion of effector T cells and Tregs, monocytosis and eosinophilia. | A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F., Free PMC Article | 01/18/2020 |
| analysis of previously unknown cis-regulatory elements in Roquin protein | Identification of new high affinity targets for Roquin based on structural conservation.
Braun J, Fischer S, Xu ZZ, Sun H, Ghoneim DH, Gimbel AT, Plessmann U, Urlaub H, Mathews DH, Weigand JE., Free PMC Article | 07/20/2019 |
| most Roquin targets are regulated by mRNA decay, whereas a small subset, including the Nfat5 mRNA, with more binding sites in their 3'-UTRs, are also subject to translational inhibition. | Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.
Essig K, Kronbeck N, Guimaraes JC, Lohs C, Schlundt A, Hoffmann A, Behrens G, Brenner S, Kowalska J, Lopez-Rodriguez C, Jemielity J, Holtmann H, Reiche K, Hackermüller J, Sattler M, Zavolan M, Heissmeyer V., Free PMC Article | 01/12/2019 |
| Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. | Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V., Free PMC Article | 02/24/2018 |
| mutations of both Regnase-1 and Roquin in T cells leads to massive lymphocyte activation and increased TH1 cells. In contrast, mutation of either Regnase-1 or Roquin affected T cell activation to a lesser extent than the double mutation, indicating that Regnase-1 and Roquin function nonredundantly in T cells. Regnase-1 is capable of repressing Roquin mRNA. | Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.
Cui X, Mino T, Yoshinaga M, Nakatsuka Y, Hia F, Yamasoba D, Tsujimura T, Tomonaga K, Suzuki Y, Uehata T, Takeuchi O. | 12/30/2017 |
| Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional T cells and specialization of Treg cells. | Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V. | 12/30/2017 |
| these studies suggest that modulation of Roquin in myeloid cells may reduce both inflammation and bacterial growth during the chronic phase of Mycobacterium tuberculosis infection | Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation.
Nagalingam G, Vinuesa CG, Britton WJ, Saunders BM., Free PMC Article | 09/30/2017 |
| RC3H1 is a multifunctional regulator of immune homeostasis. (Review) | Roquin--a multifunctional regulator of immune homeostasis.
Schaefer JS, Klein JR., Free PMC Article | 12/17/2016 |
| The authors unexpectedly uncover a ROQUIN-AMPK metabolic signaling nexus essential for selectively promoting T follicular helper cell responses. | Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.
Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard JI, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa CG, Athanasopoulos V., Free PMC Article | 10/22/2016 |
| Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes. | Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M., Free PMC Article | 09/3/2016 |
| Roquin also directly binds Argonaute2, a central component of the RNA-induced silencing complex, and miR-146a, a microRNA that targets Icos mRNA. | Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T, Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A, Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ, Vinuesa CG., Free PMC Article | 02/6/2016 |
| small intestinal inflammation in Rc3h1(san/san) and Rc3h1(gt/gt) mice is due to a failure of Roquin expression in the immune system and not to insufficient systemic Roquin expression. | Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice.
Montufar-Solis D, Vigneswaran N, Nakra N, Schaefer JS, Klein JR., Free PMC Article | 10/24/2015 |
| Over-expression of Roquin exacerbates T-cell mediated hepatitis. | Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter.
Ji YR, Kim HJ, Yu DH, Bae KB, Park SJ, Park SJ, Jang WY, Kang MC, Jeong J, Sung YH, Choi M, Park T, Park T, Yun JW, Lee HS, Lee S, Kim MO, Ryoo ZY. | 02/28/2015 |
| Roquin inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6, ICOS, c-Rel, IRF4, IkappaBNS and IkappaBzeta. | Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V. | 01/10/2015 |
| Results show an opposing relationship between Roquin-1 and the IL-17a proinflammatory cytokine. Enforced expression of Rc3h1 restricts Il17a expression, and exposure of T cells to IL-10 increases Rc3h1 expression. | A role for IL-10 in the transcriptional regulation of Roquin-1.
Schaefer JS, Montufar-Solis D, Klein JR., Free PMC Article | 10/25/2014 |
| Roquin makes mainly non-sequence-specific contacts to the RNA, binding a more relaxed constitutive decay element consensus sequence than previously thought. | Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M. | 10/11/2014 |
| Study shows that neither alteration of ROQUIN gene nor deregulation of miR101 expression is likely to be a frequent recurrent event in AITL. | ROQUIN/RC3H1 alterations are not found in angioimmunoblastic T-cell lymphoma.
Auguste T, Travert M, Tarte K, Amé-Thomas P, Artchounin C, Martin-Garcia N, de Reynies A, de Leval L, Gaulard P, Delfau-Larue MH., Free PMC Article | 01/18/2014 |
| Extensive cytokine dysregulation resulting in both over-expression and under-expression of chemotactic cytokines occurred in the ileum of Roquin(san/san) mice, the region most prone to the development of inflammation | Small intestine inflammation in Roquin-mutant and Roquin-deficient mice.
Schaefer JS, Montufar-Solis D, Nakra N, Vigneswaran N, Klein JR., Free PMC Article | 09/7/2013 |
| Study demonstrates that the constitutive decay element folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin initiates degradation of TNF-alpha mRNA and limits TNF-alpha production in macrophages. | Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
Leppek K, Schott J, Reitter S, Poetz F, Hammond MC, Stoecklin G. | 07/20/2013 |
| Roquin-1 and Roquin-2 proteins redundantly repressed the mRNA of inducible costimulator (Icos) and identified the Ox40 costimulatory receptor as another shared mRNA target. | Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V. | 07/13/2013 |
| overexpression of Roquin exacerbates the development of CIA and that enforced expression of Roquin in T cells may promote autoimmune diseases such as CIA | Enforced expression of roquin protein in T cells exacerbates the incidence and severity of experimental arthritis.
Ji YR, Kim HJ, Yu DH, Bae KB, Park SJ, Yi JK, Kim N, Park SJ, Oh KB, Hwang SS, Lee S, Kim SH, Kim MO, Lee JW, Ryoo ZY., Free PMC Article | 02/16/2013 |