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    KLRD1 killer cell lectin like receptor D1 [ Homo sapiens (human) ]

    Gene ID: 3824, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic stem cell tranplantation is predictive of subsequent relapse and survival.

    Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic stem cell tranplantation is predictive of subsequent relapse and survival.
    Verma K, Croft W, Pearce H, Zuo J, Stephens C, Nunnick J, Kinsella FA, Malladi R, Moss P., Free PMC Article

    02/11/2023
    Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.

    Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.
    Puiggros A, Blanco G, Muntasell A, Rodríguez-Rivera M, Nonell L, Altadill M, Puigdecanet E, Arnal M, Calvo X, Gimeno E, Abella E, Abrisqueta P, Bosch F, Yélamos J, Ferrer A, López-Botet M, Espinet B.

    12/4/2021
    KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.

    KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.
    Zhang Q, Zheng Y, Ning M, Li T., Free PMC Article

    10/16/2021
    CD94 expression patterns in reactive and neoplastic T-cell and NK-cell proliferations.

    CD94 expression patterns in reactive and neoplastic T-cell and NK-cell proliferations.
    Fang H, Wang W, Kadia TM, El Hussein S, Wang SA, Khoury JD.

    09/25/2021
    The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.

    The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.
    Shreeve N, Depierreux D, Hawkes D, Traherne JA, Sovio U, Huhn O, Jayaraman J, Horowitz A, Ghadially H, Perry JRB, Moffett A, Sled JG, Sharkey AM, Colucci F., Free PMC Article

    09/18/2021
    HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity.

    HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity.
    Djaoud Z, Parham P.

    06/5/2021
    NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.

    NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.
    Hò GT, Celik AA, Huyton T, Hiemisch W, Blasczyk R, Simper GS, Bade-Doeding C., Free PMC Article

    02/13/2021
    The inhibitory receptor CD94/NKG2A on CD8(+) tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/beta2m overexpression.

    The inhibitory receptor CD94/NKG2A on CD8(+) tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression.
    Eugène J, Jouand N, Ducoin K, Dansette D, Oger R, Deleine C, Leveque E, Meurette G, Podevin J, Matysiak T, Bennouna J, Bezieau S, Volteau C, Thomas WEA, Chetritt J, Kerdraon O, Fourquier P, Thibaudeau E, Dumont F, Mosnier JF, Toquet C, Jarry A, Gervois N, Bossard C.

    02/2/2021
    an early response by KLRD1-expressing Natural killer cells may control influenza infection.

    KLRD1-expressing natural killer cells predict influenza susceptibility.
    Bongen E, Vallania F, Utz PJ, Khatri P., Free PMC Article

    11/10/2018
    Collectively, these results provide evidence for the first time that CD94/NKG2C is involved in chronic graft-versus-host disease prevention

    The Activating NKG2C Receptor Is Significantly Reduced in NK Cells after Allogeneic Stem Cell Transplantation in Patients with Severe Graft-versus-Host Disease.
    Kordelas L, Steckel NK, Horn PA, Beelen DW, Rebmann V., Free PMC Article

    04/1/2017
    CD94 and NKG2A polymorphisms may contribute to genetic susceptibility to rheumatoid arthritis or affect the response to anti-TNF therapy in patients of Caucasian origin.

    Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment.
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K.

    09/17/2016
    Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.

    NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.
    Anton OM, Vielkind S, Peterson ME, Tagaya Y, Long EO., Free PMC Article

    02/27/2016
    it is not clear if high expression of CD94 on peripheral blood NK cells is related to abnormal activity of endometrial NK cells.

    Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure.
    Ghafourian M, Karami N, Khodadadi A, Nikbakht R.

    02/28/2015
    Data indicate that NKG2 receptor NKG2E was capable of associating with CD94 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum.

    Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
    Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B., Free PMC Article

    10/4/2014
    Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

    Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
    Nielsen N, Pascal V, Fasth AE, Sundström Y, Galsgaard ED, Ahern D, Andersen M, Baslund B, Bartels EM, Bliddal H, Feldmann M, Malmström V, Berg L, Spee P, Söderström K., Free PMC Article

    09/13/2014
    Data indicate that the expression of KLRD1 (CD94) and NKG2E (KLRC3) was reduced in NK-enriched cells in fulminant type 1 diabetes.

    Low gene expression levels of activating receptors of natural killer cells (NKG2E and CD94) in patients with fulminant type 1 diabetes.
    Nakata S, Imagawa A, Miyata Y, Yoshikawa A, Kozawa J, Okita K, Funahashi T, Nakamura S, Matsubara K, Iwahashi H, Shimomura I.

    07/26/2014
    NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.

    NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.
    Muntasell A, López-Montañés M, Vera A, Heredia G, Romo N, Peñafiel J, Moraru M, Vila J, Vilches C, López-Botet M.

    03/22/2014
    Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.

    Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.
    Cheent KS, Jamil KM, Cassidy S, Liu M, Mbiribindi B, Mulder A, Claas FH, Purbhoo MA, Khakoo SI., Free PMC Article

    12/14/2013
    Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function.

    Human leukocyte antigen E in human cytomegalovirus infection: friend or foe?
    Gong F, Song S, Lv G, Pan Y, Zhang D, Jiang H.

    11/3/2012
    Results suggested that the low expression level of CD94/NKG2A upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.

    Downregulation of CD94/NKG2A inhibitory receptor on decreased γδ T cells in patients with systemic lupus erythematosus.
    Wang L, Kang N, Zhou J, Guo Y, Zhang X, Cui L, Ba D, He W.

    09/22/2012
    Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A

    Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
    Nielsen N, Ødum N, Ursø B, Lanier LL, Spee P., Free PMC Article

    09/1/2012
    Loss of CD94 is associated with rheumatoid arthritis.

    Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.
    Walsh CE, Ryan EJ, O'Farrelly C, Golden-Mason L, FitzGerald O, Veale DJ, Bresnihan B, Fearon U., Free PMC Article

    05/12/2012
    These results suggested that these glycans can interact with NKG2D and CD94 to modulate NK cell-dependent cytotoxicity.

    Binding affinities of NKG2D and CD94 to sialyl Lewis X-expressing N-glycans and heparin.
    Higai K, Suzuki C, Imaizumi Y, Xin X, Azuma Y, Matsumoto K.

    05/21/2011
    The differences of CD94 and NKG2 expression between nasal NK/T-cell lymphomas and B cell lymphoma or T cell lymphoma were statistically significant.

    [Study on expression of natural killer (NK) cell C-type lectin-like receptors in nasal NK/T-cell lymphomas].
    Nong L, Zhang S, Li Y, Zhang Y, Wang Y, Li T.

    04/16/2011
    increased expression on natural killer cells in women with recurrent spontaneous abortion after IVIG therapy

    A high dose of intravenous immunoglobulin increases CD94 expression on natural killer cells in women with recurrent spontaneous abortion.
    Shimada S, Takeda M, Nishihira J, Kaneuchi M, Sakuragi N, Minakami H, Yamada H.

    05/31/2010
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