| Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing. | Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing.
Kikuchi M, Viet J, Nagata K, Sato M, David G, Audic Y, Silverman MA, Yamamoto M, Akatsu H, Hashizume Y, Takeda S, Akamine S, Miyamoto T, Uozumi R, Gotoh S, Mori K, Ikeda M, Paillard L, Morihara T. | 06/17/2024 |
| Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. | Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
Chen XQ, Das U, Park G, Mobley WC., Free PMC Article | 08/14/2021 |
| Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. | Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
Mórotz GM, Glennon EB, Greig J, Lau DHW, Bhembre N, Mattedi F, Muschalik N, Noble W, Vagnoni A, Miller CCJ., Free PMC Article | 09/26/2020 |
| LMTK2 binds to KLC1 to direct axonal transport of p35 and its loss may contribute to Alzheimer's disease. | LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
Mórotz GM, Glennon EB, Gomez-Suaga P, Lau DHW, Robinson ED, Sedlák É, Vagnoni A, Noble W, Miller CCJ., Free PMC Article | 04/25/2020 |
| TGF-beta mediated pro-invasive activity was found to be dependent on KIF5B expression. In contrast, the epithelial differentiation factor and EMT suppressor prolactin (PRL) was found to repress KIF5B gene expression and KIF5B-Snail1 nuclear accumulation, but enhanced KLC1 gene expression and KIF5B-KLC1 interaction. | A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
Moamer A, Hachim IY, Binothman N, Wang N, Lebrun JJ, Ali S., Free PMC Article | 01/11/2020 |
| these studies demonstrate that kinesin 1 regulates ciliogenesis through CCDC28B | Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, González-Sapienza G, Irigoín F, Badano JL., Free PMC Article | 11/30/2019 |
| extensive biochemical characterization of the KLC:JIP1 interaction, as well as identification of potential KLC1-binding partners, improves the understanding of how this growing family of cargos is recruited to kinesin1 by KLC1. | Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).
Nguyen TQ, Aumont-Nicaise M, Andreani J, Velours C, Chenon M, Vilela F, Geneste C, Varela PF, Llinas P, Ménétrey J., Free PMC Article | 03/2/2019 |
| structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding | Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
Nguyen TQ, Chenon M, Vilela F, Velours C, Aumont-Nicaise M, Andreani J, Varela PF, Llinas P, Ménétrey J., Free PMC Article | 11/11/2017 |
| All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. | A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC.
Taylor CA, Miller BR 3rd, Shah SS, Parish CA. | 06/24/2017 |
| BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. | BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
Akamatsu R, Ishida-Kitagawa N, Aoyama T, Oka C, Kawaichi M. | 09/26/2015 |
| The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development. | The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population.
Wu M, Zheng C, Yuan RD, Sun M, Xu Y, Ye J., Free PMC Article | 09/12/2015 |
| Dnm1L interacts with KLC1 through the tetratricopeptide repeat domains. | Dynamin-1-like protein (Dnm1L) interaction with kinesin light chain 1 (KLC1) through the tetratricopeptide repeat (TPR) domains.
Jang WH, Jeong YJ, Choi SH, Kim SJ, Urm SH, Seog DH. | 07/25/2015 |
| Microtubule-bound kinesin-1 and kinesin-3 motor domains were visualized at multiple steps in their ATPase cycles--including their nucleotide-free states--at approximately 7 A resolution using cryo-electron microscopy. | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.
Atherton J, Farabella I, Yu IM, Rosenfeld SS, Houdusse A, Topf M, Moores CA., Free PMC Article | 07/4/2015 |
| Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. | Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).
Alborghetti MR, Furlan Ada S, da Silva JC, Sforça ML, Honorato RV, Granato DC, dos Santos Migueleti DL, Neves JL, de Oliveira PS, Paes-Leme AF, Zeri AC, de Torriani IC, Kobarg J., Free PMC Article | 08/9/2014 |
| The expression levels of KLC1 variant E in brain and lymphocytes were significantly higher in Alzheimer's disease patients. | Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.
Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M., Free PMC Article | 04/19/2014 |
| study provides evidence that the combined effect of three variants within the KLC1 gene may predispose to age-related cataract. | Association of a rare haplotype in Kinesin light chain 1 gene with age-related cataract in a han chinese population.
Zhang L, Xu JW, Qu X, Liu DR, Liu P, Zhao XZ., Free PMC Article | 01/18/2014 |
| For the binding of cargos shared by KLC1, we propose a different site located within the groove but not involving N343. | Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.
Zhu H, Lee HY, Tong Y, Hong BS, Kim KP, Shen Y, Lim KJ, Mackenzie F, Tempel W, Park HW., Free PMC Article | 08/4/2012 |
| Data suggest that KLC1 is required for normal neural differentiation, ensuring proper metabolism of AD-associated molecules APP and Tau and for proliferation of neural precursors (NPs). | Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.
Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS., Free PMC Article | 06/16/2012 |
| Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. | Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.
Vagnoni A, Rodriguez L, Manser C, De Vos KJ, Miller CC., Free PMC Article | 07/23/2011 |
| Results do not convincingly support kinesin light chain 1 (KLC1) as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract. | Kinesin light chain 1 gene haplotypes in three conformational diseases.
von Otter M, Landgren S, Nilsson S, Lundvall C, Minthon L, Bogdanovic N, Andreasen N, Gustafson DR, Skoog I, Wallin A, Håkansson A, Nissbrandt H, Zetterberg M, Tasa G, Blennow K, Zetterberg H, von Otter M, Landgren S, Nilsson S, Lundvall C, Minthon L, Bogdanovic N, Andreasen N, Gustafson DR, Skoog I, Wallin A, Håkansson A, Nissbrandt H, Zetterberg M, Tasa G, Blennow K, Zetterberg H. | 01/15/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.
Figl A, Scherer D, Nagore E, Bermejo JL, Botella-Estrada R, Gast A, Thirumaran RK, Planelles D, Hemminki K, Schadendorf D, Kumar R. | 09/15/2010 |
| The rs8702 variant of the kinesin light chain 1 genotype proved to exert strong amplifying effects on the occurrence and severity of leukoaraiosis in patients with long-lasting poorly controlled severe hypertension | Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension.
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. | 01/21/2010 |
| The KLC1 56836CC variant exerts a significant protective effect on the occurrence of multiple sclerosis. | A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (11) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Kinesin light chain 1 gene haplotypes in three conformational diseases.
von Otter M, Landgren S, Nilsson S, Lundvall C, Minthon L, Bogdanovic N, Andreasen N, Gustafson DR, Skoog I, Wallin A, Håkansson A, Nissbrandt H, Zetterberg M, Tasa G, Blennow K, Zetterberg H, von Otter M, Landgren S, Nilsson S, Lundvall C, Minthon L, Bogdanovic N, Andreasen N, Gustafson DR, Skoog I, Wallin A, Håkansson A, Nissbrandt H, Zetterberg M, Tasa G, Blennow K, Zetterberg H. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke.
Szolnoki Z, Serly J, Kondacs A, Mandi Y, Somogyvari F. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension.
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis.
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization.
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
Andersson ME, Zetterberg M, Tasa G, Seibt-Palmér M, Juronen E, Teesalu P, Blennow K, Zetterberg H. Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
Andersson ME, Sjölander A, Andreasen N, Minthon L, Hansson O, Bogdanovic N, Jern C, Jood K, Wallin A, Blennow K, Zetterberg H. Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease.
Dhaenens CM, Van Brussel E, Schraen-Maschke S, Pasquier F, Delacourte A, Sablonnière B. | 03/13/2008 |