| Peroxisomal ERK mediates Akh/glucagon action and glycemic control. | Peroxisomal ERK mediates Akh/glucagon action and glycemic control.
Li J, Dang P, Li Z, Zhao T, Cheng D, Pan D, Yuan Y, Song W. | 12/4/2023 |
| GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster. | GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster.
Ben-Menahem D., Free PMC Article | 06/19/2021 |
| AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections. | AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections.
He Q, Du J, Wei L, Zhao Z., Free PMC Article | 01/2/2021 |
| Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila. | Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.
Xu Y, Borcherding AF, Heier C, Tian G, Roeder T, Kühnlein RP., Free PMC Article | 09/19/2020 |
| dilp2 modulates lifespan in part by regulating Akh, and by repressing dilp1, which acts as a pro-longevity insulin-like peptide. | Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2.
Post S, Liao S, Yamamoto R, Veenstra JA, Nässel DR, Tatar M., Free PMC Article | 04/4/2020 |
| Data (including data from studies using transgenic and mutant strains) suggest that Akh plays role in control of energy metabolism in this species; lipids appear to be main energy reserve during starvation; once glycogen stores are exhausted, carbohydrates are synthesized from other sources. | Role of adipokinetic hormone during starvation in Drosophila.
Mochanová M, Tomčala A, Svobodová Z, Kodrík D. | 10/6/2018 |
| During adulthood, however, AKH regulates body fat content and the hemolymph sugar level as well as nutritional and oxidative stress responses. Finally, we provide evidence for a negative autoregulatory loop in Akh gene regulation. | Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants.
Gáliková M, Diesner M, Klepsatel P, Hehlert P, Xu Y, Bickmeyer I, Predel R, Kühnlein RP., Free PMC Article | 07/16/2016 |
| Akh is an important regulator of metabolic homeostasis in Drosophila | Targeted mutagenesis and functional analysis of adipokinetic hormone-encoding gene in Drosophila.
Sajwan S, Sidorov R, Stašková T, Žaloudíková A, Takasu Y, Kodrík D, Zurovec M. | 04/16/2016 |
| AKH signaling is required in insulin-producing cells for sugar-dependent Dilp3 release. | Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3.
Kim J, Neufeld TP., Free PMC Article | 04/9/2016 |
| Data (including data from studies using transgenic flies) suggest that FoxO (forkhead box sub-group O) acts downstream of AKH (adipokinetic hormone) as transcription factor to mediate response to oxidative stress. | Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila--a role for dFoxO?
Bednářová A, Kodrík D, Krishnan N. | 01/16/2016 |
| Loss of ppk28 increased neuronal glucagon-like adipokinetic hormone (AKH) signaling, and the AKH receptor was necessary for ppk28 mutant effects. | Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.
Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SD., Free PMC Article | 08/23/2014 |
| AKH has a role in the regulation of starvation-induced foraging behavior | Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster.
Lee G, Park JH., Free PMC Article | 01/21/2010 |
| Identification of G protein-coupled receptors for Drosophila supports a theory of ligand-receptor coevolution. | Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution.
Park Y, Kim YJ, Adams ME., Free PMC Article | 01/21/2010 |
| Molecular identification of the insect adipokinetic hormone receptors | Molecular identification of the insect adipokinetic hormone receptors.
Staubli F, Jorgensen TJ, Cazzamali G, Williamson M, Lenz C, Sondergaard L, Roepstorff P, Grimmelikhuijzen CJ., Free PMC Article | 01/21/2010 |