| Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression. | Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression.
Creasy KT, Ren H, Jiang J, Peterson ML, Spear BT., Free PMC Article | 11/30/2023 |
| Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response. | Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
Tan S, Wang Z, Li N, Guo X, Zhang Y, Ma H, Peng X, Zhao Y, Li C, Gao L, Li T, Liang X, Ma C., Free PMC Article | 09/12/2023 |
| Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice. | Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice.
Jiang J, Turpin C, Qiu GS, Xu M, Lee E, Hinds TD Jr, Peterson ML, Spear BT., Free PMC Article | 12/3/2022 |
| Novel regulation of the transcription factor ZHX2 by N-terminal methylation. | Novel regulation of the transcription factor ZHX2 by N-terminal methylation.
Conner MM, Parker HV, Falcone DR, Chung G, Schaner Tooley CE., Free PMC Article | 09/24/2022 |
| Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward. | Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.
Beierle JA, Yao EJ, Goldstein SI, Lynch WB, Scotellaro JL, Shah AA, Sena KD, Wong AL, Linnertz CL, Averin O, Moody DE, Reilly CA, Peltz G, Emili A, Ferris MT, Bryant CD., Free PMC Article | 07/30/2022 |
| The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog. | The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog.
Zhao Y, Gao L, Jiang C, Chen J, Qin Z, Zhong F, Yan Y, Tong R, Zhou M, Yuan A, Pu J. | 05/14/2022 |
| Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity. | Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.
Tan S, Guo X, Li M, Wang T, Wang Z, Li C, Wu Z, Li N, Gao L, Liang X, Ma C., Free PMC Article | 11/27/2021 |
| Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3. | Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
Wang Z, Kong L, Tan S, Zhang Y, Song X, Wang T, Lin Q, Wu Z, Xiang P, Li C, Gao L, Liang X, Ma C. | 01/2/2021 |
| On the high-fat chow, BALB/cJ mice with a mutation encoding the transcription factor Zinc fingers and homeoboxes 2 (Zhx2) have increased weight gain, increased liver:body weight ratio, elevated hepatic lipid accumulation and markers of liver damage when compared to BALB/c mice. These traits in BALB/cJ mice are only partially reversed by a hepatocyte-specific Zhx2 transgene. | Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2.
Clinkenbeard EL, Turpin C, Jiang J, Peterson ML, Spear BT., Free PMC Article | 05/30/2020 |
| Zhx2 is expressed in developing retina. Zhx2 is essential for subsets of bipolar cell proper differentiation. Overexpression of Zhx2 showed perturbation of bipolar differentiation. | The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S. | 01/19/2019 |
| Additional Cyp genes are disregulated in the absence of Zhx2. | Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.
Creasy KT, Jiang J, Ren H, Peterson ML, Spear BT., Free PMC Article | 10/7/2017 |
| Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes | Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver.
Jiang J, Creasy KT, Purnell J, Peterson ML, Spear BT., Free PMC Article | 06/24/2017 |
| NFAT1 protein activation can shift oncogenic Ras/Raf/MEK/ERK signaling to acting as a tumor suppressor pathway. | The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK/ERK pathway and upregulation of TNF-α expression.
Robbs BK, Lucena PI, Viola JP. | 09/21/2013 |
| The Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase, a gene normally silenced in the adult liver. | Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism.
Gargalovic PS, Erbilgin A, Kohannim O, Pagnon J, Wang X, Castellani L, LeBoeuf R, Peterson ML, Spear BT, Lusis AJ., Free PMC Article | 05/31/2010 |
| molecular crosstalk between aberrant expression of Hox molecule(s) and activated Raf may have a key role in the MLL-fusion-mediated-leukemogenesis | Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.
Ono R, Kumagai H, Nakajima H, Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y, Kitamura T, Nosaka T. | 01/21/2010 |
| These findings revealed that oxidative stress, inflammation, Ras/Raf/ERK1/2 pathway and apoptosis collectively played a crucial role in the chemopreventive activity of farnesol to inhibit the murine skin tumorigenesis. | Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.
Chaudhary SC, Alam MS, Siddiqui MS, Athar M. | 01/21/2010 |
| evidence presented that ZHX2 & ephrin-B1 cytoplasmic domain can interact & regulate transcription; study identifies ZHX2 as novel regulator of neural progenitor cell maintenance & suggests potential nuclear mechanism of ephrin-B function in the cortex | ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex.
Wu C, Qiu R, Wang J, Zhang H, Murai K, Lu Q., Free PMC Article | 01/21/2010 |
| The carboxyl terminus of Angptl4 alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf/MEK/ERK1/2 MAP kinase pathway in endothelial cells. | Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.
Yang YH, Wang Y, Lam KS, Yau MH, Cheng KK, Zhang J, Zhu W, Wu D, Xu A. | 01/21/2010 |
| Zhx2 acts as a repressor of Gpc3 in the adult liver. | The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2.
Morford LA, Davis C, Jin L, Dobierzewska A, Peterson ML, Spear BT. | 01/21/2010 |
| ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease | ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
Liu G, Clement LC, Kanwar YS, Avila-Casado C, Chugh SS. | 01/21/2010 |