| Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways. | Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways.
Morris HE, Neves KB, Nilsen M, Montezano AC, MacLean MR, Touyz RM., Free PMC Article | 07/23/2023 |
| Repression of FBXW7 by HES5 contributes to inactivation of the TGF-beta signaling pathway and alleviation of endometriosis. | Repression of FBXW7 by HES5 contributes to inactivation of the TGF-β signaling pathway and alleviation of endometriosis.
Chen LJ, Hu B, Han ZQ, Liu W, Zhu JH, Chen XX, Li ZP, Zhou H. | 06/26/2021 |
| NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis. | NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.
Luiken S, Fraas A, Bieg M, Sugiyanto R, Goeppert B, Singer S, Ploeger C, Warsow G, Marquardt JU, Sticht C, De La Torre C, Pusch S, Mehrabi A, Gretz N, Schlesner M, Eils R, Schirmacher P, Longerich T, Roessler S., Free PMC Article | 12/12/2020 |
| HES5 might contribute to the proliferation of non-small cell lung cancer by STAT3 signaling. | HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling.
Gu S, Zhang R, Gu J, Li X, Lv L, Jiang J, Xu Z, Wang S, Shi C, Wang DP, Wu C. | 04/8/2017 |
| that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma | HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma.
Zhu G, Shi W, Fan H, Zhang X, Xu J, Chen Y, Xu Z, Tao T, Cheng C. | 04/23/2016 |
| HES5 silencing is an early and recurrent change in prostate tumourigenesis | HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Massie CE, Spiteri I, Ross-Adams H, Luxton H, Kay J, Whitaker HC, Dunning MJ, Lamb AD, Ramos-Montoya A, Brewer DS, Cooper CS, Eeles R, UK Prostate ICGC Group, Warren AY, Tavaré S, Neal DE, Lynch AG., Free PMC Article | 12/5/2015 |
| these data identify HES5 as a key mediator of the Wnt-3a proneurogenic effect occurring independently of the classical Wnt/beta-catenin signaling cascade thus further deciphering crosstalk mechanisms of Wnt and Notch signaling pathways regulating cell fate | HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.
Mußmann C, Hübner R, Trilck M, Rolfs A, Frech MJ. | 02/14/2015 |
| the downstream Notch signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta. | Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A., Free PMC Article | 01/11/2014 |
| Notch3 and Hes5 are hypermethylated in human B cell acute lymphoblastic leukemia (ALL). | Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.
Kuang SQ, Fang Z, Zweidler-McKay PA, Yang H, Wei Y, Gonzalez-Cervantes EA, Boumber Y, Garcia-Manero G., Free PMC Article | 11/16/2013 |
| Hes5 overactivation is associated with cell differentiation, thereby resulting in uterine carcinogenesis. | Hes1/Hes5 gene inhibits differentiation via down-regulating Hash1 and promotes proliferation in cervical carcinoma cells.
Liu J, Lu WG, Ye F, Cheng XD, Hong D, Hu Y, Chen HZ, Xie X. | 07/23/2011 |
| In this study, HES 5 transcription factor was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch pathway activation in those cells. | Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts.
Meliou E, Kerezoudis N, Tosios K, Lafkas D, Kiaris H. | 05/21/2011 |
| The expression of HES5 in adenocarcinoma was significantly higher than those in adenoma and normal control | The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study.
Wang X, Fu Y, Chen X, Ye J, Lü B, Ye F, Lü W, Xie X., Free PMC Article | 06/28/2010 |
| Data show that HES5 are abundantly expressed in osteoarthritis. | Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis.
Karlsson C, Brantsing C, Egell S, Lindahl A. | 01/21/2010 |
| regulates brain development process.[review] | [Transcription factor network that regulates brain development].
Kageyama R. | 01/21/2010 |
| expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia | Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors.
Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X. | 01/21/2010 |
| Human HES5 gene is coupled to the Notch receptor family and expression of Notch markers (including HES5) decreases during cartilage differentiation. | Notch and HES5 are regulated during human cartilage differentiation.
Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A. | 01/21/2010 |
| The HLH gene HES5 on the other hand was only detected in chondrocytes. | Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors.
Karlsson C, Brantsing C, Svensson T, Brisby H, Asp J, Tallheden T, Lindahl A. | 01/21/2010 |