| Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization. | Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization.
Simon N, Safyan A, Pyrowolakis G, Matsuda S., Free PMC Article | 02/29/2024 |
| Dally and Dally-like, are necessary for injury-induced thermal allodynia | Glypicans Dally and Dally-like control injury-induced allodynia in Drosophila.
Brann CL, Moulton JK, Ganter GK., Free PMC Article | 05/30/2020 |
| dally is essential for normal follicle stem cell maintenance. | Drosophila Glypicans Regulate Follicle Stem Cell Maintenance and Niche Competition.
Su TY, Nakato E, Choi PY, Nakato H., Free PMC Article | 10/6/2018 |
| ECM over planar cell polarity mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally). | Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes.
Huang H, Kornberg TB., Free PMC Article | 11/25/2017 |
| Autonomous and nonautonomous effects on Drosophila tissue growth rely on the up-regulation of the proteoglycan Dally. Dally also contributes to integrating nutrient sensing and organ scaling, the fitting of pattern to size. | Dally Proteoglycan Mediates the Autonomous and Nonautonomous Effects on Tissue Growth Caused by Activation of the PI3K and TOR Pathways.
Ferreira A, Milán M., Free PMC Article | 04/9/2016 |
| analysis of balancing between hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif | Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.
Bilioni A, Sánchez-Hernández D, Callejo A, Gradilla AC, Ibáñez C, Mollica E, Carmen Rodríguez-Navas M, Simon E, Guerrero I. | 05/18/2013 |
| data suggest that Dally and Dlp are essential regulators for Upd distribution and JAK/STAT signaling activity in eye development | Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.
Zhang Y, You J, Ren W, Lin X., Free PMC Article | 04/20/2013 |
| findings demonstrate that the glypican dally regulates formation of the follicular gradient of the Upd morphogen, Upd | Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Hayashi Y, Sexton TR, Dejima K, Perry DW, Takemura M, Kobayashi S, Nakato H, Harrison DA., Free PMC Article | 01/26/2013 |
| Dally is necessary to sequester Hedgehog at the cell surface and to promote Hedgehog internalisation with its receptor. | Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling.
Ayers KL, Mteirek R, Cervantes A, Lavenant-Staccini L, Thérond PP, Gallet A. | 10/20/2012 |
| DALLY regulates DPP signaling in trans by its effect on the stability of DPP protein on the surface of the contacting cells | Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans.
Dejima K, Kanai MI, Akiyama T, Levings DC, Nakato H., Free PMC Article | 07/16/2011 |
| the long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum | The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum.
Ayers KL, Gallet A, Staccini-Lavenant L, Thérond PP. | 05/10/2010 |
| Dally is required for restriction of the female germline stem cell niche space. | Drosophila glypicans regulate the germline stem cell niche.
Hayashi Y, Kobayashi S, Nakato H., Free PMC Article | 01/21/2010 |
| Dally is required for short-range BMP signaling in germline but not in somatic cells. | The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary.
Guo Z, Wang Z. | 01/21/2010 |
| Dally, a heparan sulfate proteoglycan, regulates both the distribution of Dpp morphogen and cellular responses to Dpp by stabilizing Dpp in the extracellular matrix. | Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface.
Akiyama T, Kamimura K, Firkus C, Takeo S, Shimmi O, Nakato H., Free PMC Article | 01/21/2010 |
| role in Hedgehog signal transduction in Drosophila embryo. | The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila.
Desbordes SC, Sanson B. | 01/21/2010 |
| Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. | Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog.
Takeo S, Akiyama T, Firkus C, Aigaki T, Nakato H. | 01/21/2010 |
| The gene encodes an integral membrane proteoglycan of the glypican family that affects a number of patterning events during both embryonic and larval development. | dally, a Drosophila member of the glypican family of integral membrane proteoglycans, affects cell cycle progression and morphogenesis via a Cyclin A-mediated process.
Nakato H, Fox B, Selleck SB. | 01/21/2010 |
| Heparan sulfate modification of Dally is not required for all in vivo activities; significant functional capacity resides in the protein core. | The function of a Drosophila glypican does not depend entirely on heparan sulfate modification.
Kirkpatrick CA, Knox SM, Staatz WD, Fox B, Lercher DM, Selleck SB. | 01/21/2010 |
| Dally, could act as a classical co-receptor. | Glypicans shunt the Wingless signal between local signalling and further transport.
Franch-Marro X, Marchand O, Piddini E, Ricardo S, Alexandre C, Vincent JP. | 01/21/2010 |
| Results support a model in which Dpp moves along the cell surface by restricted extracellular diffusion involving the glypicans Dally and Dly, and that this is not blocked by the dynamin mutant shibire. | Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.
Belenkaya TY, Han C, Yan D, Opoka RJ, Khodoun M, Liu H, Lin X. | 01/21/2010 |
| Data suggest that Dally serves as a co-receptor for Decapentaplegic (Dpp) and contributes to shaping the Dpp morphogen gradient in the developing Drosophila wing. | Dally regulates Dpp morphogen gradient formation in the Drosophila wing.
Fujise M, Takeo S, Kamimura K, Matsuo T, Aigaki T, Izumi S, Nakato H. | 01/21/2010 |