| A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster. | A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster.
Jangam SV, Briere LC, Jay KL, Andrews JC, Walker MA, Rodan LH, High FA, Undiagnosed Diseases Network, Yamamoto S, Sweetser DA, Wangler MF., Free PMC Article | 08/10/2023 |
| Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity. | Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.
Moskalev AA, Shaposhnikov MV, Zemskaya NV, Koval LА, Schegoleva EV, Guvatova ZG, Krasnov GS, Solovev IA, Sheptyakov MA, Zhavoronkov A, Kudryavtseva AV., Free PMC Article | 10/24/2020 |
| E(z) protein is required for Ci transcription. | Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila.
Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y. | 10/26/2019 |
| Drosophila Mbf1 associates with E(z) mRNA and protects it from degradation by the exoribonuclease Pacman (Pcm), thereby ensuring Polycomb silencing. | Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman.
Nishioka K, Wang XF, Miyazaki H, Soejima H, Hirose S., Free PMC Article | 04/7/2018 |
| Taken together, these data suggest that E(z) acts intrinsically in germ cells to activate dedifferentiation and thus replenish lost germline stem cells during both aging and tissue regeneration. | Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis.
Eun SH, Feng L, Cedeno-Rosario L, Gan Q, Wei G, Cui K, Zhao K, Chen X., Free PMC Article | 07/15/2017 |
| Chracterization of functionally critical SU(Z)12 elements, including key determinants of SU(Z)12-E(Z) communication. | Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function.
Rai AN, Vargas ML, Wang L, Andersen EF, Miller EL, Simon JA., Free PMC Article | 02/1/2014 |
| These results suggest that increased H3K27 trimethylation activity of E(Z)(Trm) causes the premature accumulation of H3K27me3 in early embryogenesis, "predestining" initially active Polycomb target genes to silencing once Polycomb silencing is initiated. | A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.
Stepanik VA, Harte PJ. | 11/24/2012 |
| The emerging picture presents PRC2 as a cooperative multipart machine, intricately outfitted to sense and respond to the local chromatin environment and other cues[review] | Inner workings and regulatory inputs that control Polycomb repressive complex 2.
O'Meara MM, Simon JA., Free PMC Article | 09/8/2012 |
| A Pcl-PSC2 complex is the histone methyltransferase that generates the high levels of histone3-lysine27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state. | Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.
Nekrasov M, Klymenko T, Fraterman S, Papp B, Oktaba K, Köcher T, Cohen A, Stunnenberg HG, Wilm M, Müller J., Free PMC Article | 01/21/2010 |
| The nucleosome-binding subunits Su(z)12 and Nurf55 anchor the E(z) enzyme on chromatin substrates, an essential process in maintaining HOX gene silencing during development. | Nucleosome binding and histone methyltransferase activity of Drosophila PRC2.
Nekrasov M, Wild B, Müller J., Free PMC Article | 01/21/2010 |
| ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development | Polycomb group proteins ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development.
Furuyama T, Tie F, Harte PJ. | 01/21/2010 |
| We purified an ESC-E(Z) complex from Drosophila embryos and found four major subunits: ESC, E(Z), NURF-55, and the PcG repressor, SU(Z)12. A recombinant complex reconstituted from these four subunits methylates lysine-27 of histone H3. | Histone methyltransferase activity of a Drosophila Polycomb group repressor complex.
Müller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller EL, O'Connor MB, Kingston RE, Simon JA. | 01/21/2010 |
| Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites | Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. | 01/21/2010 |
| one of the roles of ESC (and ESCL and EED) in Polycomb repressive complex 2 complexes is to enable E(Z) to utilize histone H3 as a substrate by physically linking enzyme and substrate | The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.
Tie F, Stratton CA, Kurzhals RL, Harte PJ., Free PMC Article | 01/21/2010 |