| Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer. | Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer.
Giri K, Maity S, Ambatipudi K. | 10/1/2022 |
| Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer. | Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer.
Bao W, Zhu Z, Gao Y, Chen J. | 06/11/2022 |
| LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer. | LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.
Zeng Q, Li L, Feng Z, Luo L, Xiong J, Jie Z, Cao Y, Li Z. | 10/23/2021 |
| The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer. | The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer.
Schaffner-Reckinger E, Machado RAC. | 08/28/2021 |
| Among the proteins found to preferentially bind clasped rather than the isolated alphaM and beta2 subunits was L-plastin (LCP1, also known as plastin-2), which binds to and maintains the inactive state of alphaMbeta2 integrin in vivo and thereby regulates leukocyte adhesion to integrin ligands under flow. | LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.
Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT., Free PMC Article | 01/11/2020 |
| LPL oxidation diminishes its actin-bundling capacity. | Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
Balta E, Hardt R, Liang J, Kirchgessner H, Orlik C, Jahraus B, Hillmer S, Meuer S, Hübner K, Wabnitz GH, Samstag Y., Free PMC Article | 12/21/2019 |
| LCP1-positive oral squamous cell carcnome samples were correlated closely with the primary tumor size and regional lymph node metastasis. | Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.
Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K., Free PMC Article | 11/17/2018 |
| MOLP8/R cells display a very high overexpression of LCP1 gene (l-Plastin) controlled by HIF1&alpha. | Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy.
Bosseler M, Marani V, Broukou A, Lequeux A, Kaoma T, Schlesser V, François JH, Palissot V, Berchem GJ, Aouali N, Janji B., Free PMC Article | 10/20/2018 |
| these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment. | AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin.
Chen C, Cai Q, He W, Lam TB, Lin J, Zhao Y, Chen X, Gu P, Huang H, Xue M, Liu H, Su F, Huang J, Zheng J, Lin T., Free PMC Article | 06/9/2018 |
| Mutated LCP1 is a driver of chronic lymphocytic leukemia. | Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.
Wang L, Fan J, Francis JM, Georghiou G, Hergert S, Li S, Gambe R, Zhou CW, Yang C, Xiao S, Cin PD, Bowden M, Kotliar D, Shukla SA, Brown JR, Neuberg D, Alessi DR, Zhang CZ, Kharchenko PV, Livak KJ, Wu CJ., Free PMC Article | 06/2/2018 |
| AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK, p90 ribosomal S6 kinase, PKA, or PKC. LCP1 phosphorylation increased filopodia formation. | Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes.
Schenk LK, Möller-Kerutt A, Klosowski R, Wolters D, Schaffner-Reckinger E, Weide T, Pavenstädt H, Vollenbröker B. | 11/25/2017 |
| L-plastin regulates the stability of the immune synapse of naive and effector T-cells. (Review) | L-plastin regulates the stability of the immune synapse of naive and effector T-cells.
Wabnitz G, Balta E, Samstag Y. | 11/18/2017 |
| The findings support a mechanism in which miR-375 suppresses RUNX1 levels, resulting in reduced vimentin and L-plastin expression. Knockdown of RUNX1, L-plastin, and vimentin resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion. | miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin.
Jimenez L, Lim J, Burd B, Harris TM, Ow TJ, Kawachi N, Belbin TJ, Angeletti R, Prystowsky MB, Childs G, Segall JE., Free PMC Article | 10/14/2017 |
| In this study, the authors found that the actin filament bundling abilities of PLS1 and PLS2 were similarly sensitive to Ca(2+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9). | The Roles of Actin-Binding Domains 1 and 2 in the Calcium-Dependent Regulation of Actin Filament Bundling by Human Plastins.
Schwebach CL, Agrawal R, Lindert S, Kudryashova E, Kudryashov DS. | 08/19/2017 |
| elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin levels. | Fascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia.
Van Audenhove I, Denert M, Boucherie C, Pieters L, Cornelissen M, Gettemans J., Free PMC Article | 11/5/2016 |
| Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils. | L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions.
Dubey M, Singh AK, Awasthi D, Nagarkoti S, Kumar S, Ali W, Chandra T, Kumar V, Barthwal MK, Jagavelu K, Sánchez-Gómez FJ, Lamas S, Dikshit M. | 06/4/2016 |
| association of SNPs in LCP1 and CTIF with hearing | Association of SNPs in LCP1 and CTIF with hearing in 11 year old children: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium.
Harrison S, Lewis SJ, Hall AJ, Vuckovic D, Girotto G, Martin RM, Adams JC., Free PMC Article | 03/5/2016 |
| An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer | An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer.
Chen C, Cai Q, He W, Li Z, Zhou F, Liu Z, Zhong G, Chen X, Zhao Y, Dong W, Huang J, Zheng J, Lin T. | 02/13/2016 |
| The proteins (HSP90b, TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases. | Potential diagnostic significance of HSP90, ACS/TMS1, and L-plastin in the identification of melanoma.
Strickler AG, Vasquez JG, Yates N, Ho J. | 08/15/2015 |
| Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets. | Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.
Ning Y, Gerger A, Zhang W, Hanna DL, Yang D, Winder T, Wakatsuki T, Labonte MJ, Stintzing S, Volz N, Sunakawa Y, Stremitzer S, El-Khoueiry R, Lenz HJ., Free PMC Article | 02/21/2015 |
| L-plastin plays an important role in the clustering of NKG2D into lipid rafts, and it participates in NKG2D-mediated inhibition of NK cell chemotaxis. | L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration.
Serrano-Pertierra E, Cernuda-Morollón E, Brdička T, Hoøejši V, López-Larrea C., Free PMC Article | 01/17/2015 |
| expression of L-plastin promotes tumor metastasis and, importantly, that this effect depends on an additionally required phosphorylation of L-plastin | Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation.
Riplinger SM, Wabnitz GH, Kirchgessner H, Jahraus B, Lasitschka F, Schulte B, van der Pluijm G, van der Horst G, Hämmerling GJ, Nakchbandi I, Samstag Y., Free PMC Article | 09/13/2014 |
| L-plastin is indispensable for podosome formation and function in macrophages. | L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages.
De Clercq S, Boucherie C, Vandekerckhove J, Gettemans J, Guillabert A., Free PMC Article | 09/6/2014 |
| LCP1 is functionally relevant to CXCL12 induced B-cell migration. | Lymphocyte cytosolic protein 1 is a chronic lymphocytic leukemia membrane-associated antigen critical to niche homing.
Dubovsky JA, Chappell DL, Harrington BK, Agrawal K, Andritsos LA, Flynn JM, Jones JA, Paulaitis ME, Bolon B, Johnson AJ, Byrd JC, Muthusamy N., Free PMC Article | 01/11/2014 |
| High serum LCP1 is associated with kidney cancer. | Composite three-marker assay for early detection of kidney cancer.
Su Kim D, Choi YD, Moon M, Kang S, Lim JB, Kim KM, Park KM, Cho NH. | 09/14/2013 |