| Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1. | Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.
Deng S, Qian L, Liu L, Liu H, Xu Z, Liu Y, Wang Y, Chen L, Zhou Y., Free PMC Article | 04/7/2023 |
| The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay. | The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.
Lippincott MF, Xu W, Smith AA, Miao X, Lafont A, Shennib O, Farley GJ, Sabbagh R, Delaney A, Stamou M, Plummer L, Salnikov K, Georgopoulos NA, Mericq V, Quinton R, Mau-Them FT, Nambot S, Hamad A, Brittain H, Tooze RS, Calpena E, Wilkie AOM, Willems M, Crowley WF, Balasubramanian R, Lamarche-Vane N, Davis EE, Seminara SB., Free PMC Article | 12/17/2022 |
| Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis. | Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis.
Tian T, Chen ZH, Zheng Z, Liu Y, Zhao Q, Liu Y, Qiu H, Long Q, Chen M, Li L, Xie F, Luo G, Wu X, Deng W., Free PMC Article | 07/31/2021 |
| These results indicate that SIRT1 suppresses migration and invasion of gastric cancer by downregulating ARHGAP5 through an interaction with c-JUN, and these phenomena represent a novel mechanism of the antitumor action of SIRT1. | SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.
Dong G, Wang B, An Y, Li J, Wang X, Jia J, Yang Q., Free PMC Article | 12/14/2019 |
| only collagen-IV elicits the formation of proteolytically active podosomes through a mechanism involving increased Src phosphorylation, p190RhoGAP-B (also known as ARHGAP5) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites. | VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells.
Daubon T, Spuul P, Alonso F, Fremaux I, Génot E. | 08/12/2017 |
| Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. | Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.
Mychaleckyj JC, Havt A, Nayak U, Pinkerton R, Farber E, Concannon P, Lima AA, Guerrant RL., Free PMC Article | 07/29/2017 |
| This newly identified miR-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC and indicates potential novel therapeutic targets for NPC. | MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5.
Fang Y, Zhu X, Wang J, Li N, Li D, Sakib N, Sha Z, Song W., Free PMC Article | 04/9/2016 |
| Ectopic expression of p190B suppressed the miR-494-induced EGFR upregulation. | Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B rhoGAP.
Kwak SY, Yang JS, Kim BY, Bae IH, Han YH. | 05/24/2014 |
| The expression level of miR-486-5p was inversely correlated with that of ARHGAP5. | Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer.
Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, Xue L, Liu Y, Yan X, Shen J, Mannoor K, Deepak J, Donahue JM, Stass SA, Xing L, Jiang F., Free PMC Article | 04/26/2014 |
| RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. | RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.
Ponik SM, Trier SM, Wozniak MA, Eliceiri KW, Keely PJ., Free PMC Article | 12/21/2013 |
| Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting. | Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability.
Zebda N, Tian Y, Tian X, Gawlak G, Higginbotham K, Reynolds AB, Birukova AA, Birukov KG., Free PMC Article | 09/7/2013 |
| Results link Cdk5 to Rho-ROCK signaling via Src and p190RhoGAP and implicate Cdk5 in the regulation of cell contraction, attachment, and migration. | Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP.
Tripathi BK, Zelenka PS., Free PMC Article | 01/21/2010 |
| ARHGAP5 (the gene encoding p190-B RhoGAP) is a probable target for the amplification at 14q12, and p190-B RhoGAP promotes cells spreading and migration by negatively regulating RhoA activity in Huh-7 hepatocellular carcinoma cells | A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells.
Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyoshi H, Minami M, Itoh Y, Tanaka S, Taniwaki M, Arii S, Okanoue T, Yoshikawa T. | 01/21/2010 |
| A cell cycle-regulated reduction in endogenous p190 levels is linked to completion of cytokinesis and generation of viable cell progeny. | p190RhoGAP is cell cycle regulated and affects cytokinesis.
Su L, Agati JM, Parsons SJ., Free PMC Article | 01/21/2010 |
| precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development | P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.
Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM. | 01/21/2010 |