| Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster). | Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster).
Bierlein M, Charles J, Polisuk-Balfour T, Bretscher H, Rice M, Zvonar J, Pohl D, Winslow L, Wasie B, Deurloo S, Van Wert J, Williams B, Ankney G, Harmon Z, Dann E, Azuz A, Guzman-Vargas A, Kuhns E, Neufeld TP, O'Connor MB, Amissah F, Zhu CC., Free PMC Article | 04/17/2024 |
| Atg1 modulates mitochondrial dynamics to promote germline stem cell maintenance in Drosophila. | Atg1 modulates mitochondrial dynamics to promote germline stem cell maintenance in Drosophila.
Ayachit MS, Shravage BV. | 02/4/2023 |
| Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development. | Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Gunaseelan S, Wang Z, Tong VKJ, Ming SWS, Razar RBBA, Srimasorn S, Ong WY, Lim KL, Chua JJE. | 10/9/2021 |
| Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation. | Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.
Tyra LK, Nandi N, Tracy C, Krämer H., Free PMC Article | 10/24/2020 |
| Atg1-mediated autophagy suppresses tissue degeneration in Pink1/Parkin mutants by promoting mitochondrial fission in Drosophila. | Atg1-mediated autophagy suppresses tissue degeneration in pink1/parkin mutants by promoting mitochondrial fission in Drosophila.
Ma P, Yun J, Deng H, Guo M., Free PMC Article | 06/27/2020 |
| Relish controls autophagy by regulating the expression of Atg1, a core component and activator of the autophagy pathway. | The NF-κB Factor Relish Regulates Atg1 Expression and Controls Autophagy.
Nandy A, Lin L, Velentzas PD, Wu LP, Baehrecke EH, Silverman N., Free PMC Article | 12/14/2019 |
| dAtg1 has a previously unrecognized function for both regenerative and overgrowth-promoting apoptosis-induced proliferation (AiP) in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. | Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation.
Li M, Lindblad JL, Perez E, Bergmann A, Fan Y., Free PMC Article | 10/28/2017 |
| Data indicate that autophagy-related 1 (Atg1) and ADUK/Ulk3 (CG8866) represent alternative catalytic components of a shared autophagy kinase complex. | Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK.
Braden CR, Neufeld TP., Free PMC Article | 07/15/2017 |
| The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos. | The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.
Kuhn H, Sopko R, Coughlin M, Perrimon N, Mitchison T., Free PMC Article | 03/5/2016 |
| Atg17 is required for the kinase activity of endogenous Atg1 in vivo | Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila.
Nagy P, Kárpáti M, Varga A, Pircs K, Venkei Z, Takáts S, Varga K, Erdi B, Hegedűs K, Juhász G., Free PMC Article | 04/4/2015 |
| Unc-51 plays pivotal roles in the axonal and dendritic development of the Drosophila brain | Unc-51/ATG1 controls axonal and dendritic development via kinesin-mediated vesicle transport in the Drosophila brain.
Mochizuki H, Toda H, Ando M, Kurusu M, Tomoda T, Furukubo-Tokunaga K., Free PMC Article | 09/24/2011 |
| Evidence of a link between Atg1 and the control of Atg9-mediated autophagosome formation through the myosin II motor protein. | Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.
Tang HW, Wang YB, Wang SL, Wu MH, Lin SY, Chen GC., Free PMC Article | 05/14/2011 |
| Knockout of Atg1 or Atg13 results in a similar, selective defect in autophagy in response to TOR inactivation. | An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation.
Chang YY, Neufeld TP., Free PMC Article | 01/21/2010 |
| Here we show that UNC-51/ATG1 kinase regulates the interaction between synaptic vesicles and motor complexes during transport in Drosophila. | UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly.
Toda H, Mochizuki H, Flores R 3rd, Josowitz R, Krasieva TB, Lamorte VJ, Suzuki E, Gindhart JG, Furukubo-Tokunaga K, Tomoda T., Free PMC Article | 01/21/2010 |
| Results identify a link between the focal adhesion protein paxillin and the Atg1 kinase, which has been previously implicated in autophagy. | Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation.
Chen GC, Lee JY, Tang HW, Debnath J, Thomas SM, Settleman J. | 01/21/2010 |
| central role for Atg1 in mounting a coordinated autophagic response | Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death.
Scott RC, Juhász G, Neufeld TP., Free PMC Article | 01/21/2010 |
| ATG1 is a negative regulator of the target of rapamycin (TOR)/S6 kinase (S6K) pathway. | ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase.
Lee SB, Kim S, Lee J, Park J, Lee G, Kim Y, Kim JM, Chung J., Free PMC Article | 01/21/2010 |