| Identification of bi-allelic LFNG variants in three patients and further clinical and molecular refinement of spondylocostal dysostosis 3. | Identification of bi-allelic LFNG variants in three patients and further clinical and molecular refinement of spondylocostal dysostosis 3.
Lecca M, Bedeschi MF, Izzi C, Dordoni C, Rinaldi B, Peluso F, Caraffi SG, Prefumo F, Signorelli M, Zanzucchi M, Bione S, Ghigna C, Sassi S, Novelli A, Valente EM, Superti-Furga A, Garavelli L, Errichiello E. | 07/7/2023 |
| Lunatic fringe promotes the aggregation of CADASIL NOTCH3 mutant proteins. | Lunatic fringe promotes the aggregation of CADASIL NOTCH3 mutant proteins.
Suzuki S, Hiura S, Mashiko T, Matsumoto T, Itoh M. | 08/14/2021 |
| Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers. | Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers.
Barua R, Mizuno K, Tashima Y, Ogawa M, Takeuchi H, Taguchi A, Okajima T., Free PMC Article | 04/17/2021 |
| LFNG mutation is associated with spondylocostal dysostosis. | Identification of novel LFNG mutations in spondylocostal dysostosis.
Otomo N, Mizumoto S, Lu HF, Takeda K, Campos-Xavier B, Mittaz-Crettol L, Guo L, Takikawa K, Nakamura M, Yamada S, Matsumoto M, Watanabe K, Ikegawa S. | 04/13/2019 |
| LFNG expression plays a functional role in regulating melanoma metastasis. | Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.
Del Castillo Velasco-Herrera M, van der Weyden L, Nsengimana J, Speak AO, Sjöberg MK, Bishop DT, Jönsson G, Newton-Bishop J, Adams DJ., Free PMC Article | 02/2/2019 |
| Genetic interaction between lunatic fringe and TP53 was identified in breast cancer tumorigenesis. | Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.
Chung WC, Zhang S, Challagundla L, Zhou Y, Xu K., Free PMC Article | 06/30/2018 |
| a potent tumor-suppressive function for Lfng | Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Zhang S, Chung WC, Xu K. | 09/2/2017 |
| TGFBR2 signaling can affect Notch1 glycosylation via regulation of glycosyltransferase LFNG expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells. | Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1.
Lee J, Katzenmaier EM, Kopitz J, Gebert J. | 02/25/2017 |
| LFNG expression correlates with expansion of cancer stem cell populations and NKX3.1 expression in human prostate cancer. | Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.
Zhang S, Chung WC, Wu G, Egan SE, Xu K., Free PMC Article | 12/6/2014 |
| Reduced LFNG expression facilitates JAG/NOTCH luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote basal-like breast cancer. | Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
Xu K, Usary J, Kousis PC, Prat A, Wang DY, Adams JR, Wang W, Loch AJ, Deng T, Zhao W, Cardiff RD, Yoon K, Gaiano N, Ling V, Beyene J, Zacksenhaus E, Gridley T, Leong WL, Guidos CJ, Perou CM, Egan SE., Free PMC Article | 07/28/2012 |
| Mutation of the LFNG gene causes spondylocostal dysostosis with a severe vertebral phenotype, reinforcing the hypothesis that proper regulation of the Notch signaling pathway is an absolute requirement for the correct patterning of the axial skeleton. | Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype.
Sparrow DB, Chapman G, Wouters MA, Whittock NV, Ellard S, Fatkin D, Turnpenny PD, Kusumi K, Sillence D, Dunwoodie SL., Free PMC Article | 01/21/2010 |