| E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster. | E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
Brown J, Su TT., Free PMC Article | 01/9/2024 |
| Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila. | Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
Maurya CK, Tapadia MG. | 09/26/2023 |
| Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development. | Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
Yang DW, Choi KW., Free PMC Article | 12/25/2021 |
| Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP. | Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.
Ahmad V, Vadla GP, Chabu CY. | 04/17/2021 |
| dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis. | JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling.
Recasens-Alvarez C, Ferreira A, Milán M., Free PMC Article | 11/17/2018 |
| Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to two folds) compared to mof1 mutants. | Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway.
Pushpavalli SN, Sarkar A, Ramaiah MJ, Koteswara Rao G, Bag I, Bhadra U, Pal-Bhadra M. | 10/22/2016 |
| Both germline and somatic stem cells in the adult Drosophila testis are more resistant to apoptosis-inducing stimuli than their differentiating daughters. Niche signaling causes enhanced expression of DIAP1 in both germline stem cells and somatic cyst stem cells, and the resistance to apoptosis is mediated, at least in part, by this enhanced expression. | Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1.
Hasan S, Hétié P, Matunis EL., Free PMC Article | 08/22/2015 |
| Ubr3 interacts with DIAP1 and positively regulates DIAP1 activity, possibly by maintaining its active conformation in the apoptosis pathway. | Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.
Huang Q, Tang X, Wang G, Fan Y, Ray L, Bergmann A, Belenkaya TY, Ling X, Yan D, Lin Y, Ye X, Shi W, Zhou X, Lu F, Qu J, Lin X., Free PMC Article | 07/25/2015 |
| DIAP1 contains distinct instability motifs that regulate inhibitor-of-apoptosis turnover and apoptotic consequences. | Insect inhibitor-of-apoptosis (IAP) proteins are negatively regulated by signal-induced N-terminal degrons absent within viral IAP proteins.
Vandergaast R, Mitchell JK, Byers NM, Friesen PD., Free PMC Article | 05/30/2015 |
| epithelial tube size regulation defines new non-apoptotic roles for Yki, DIAP1 and Ice | Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control.
Robbins RM, Gbur SC, Beitel GJ., Free PMC Article | 04/4/2015 |
| This study showed that Diap2 could be regulating ion channels, as loss of Diap2 consequently reduces the expression of ion channels and affects the balance of ion concentrations which results in reduced uric acid deposition. | Epithelial immune response in Drosophila malpighian tubules: interplay between Diap2 and ion channels.
Verma P, Tapadia MG. | 07/26/2014 |
| DIAP1 is an important survival factor that inhibits premature death of CCAP-expressing neurons. | Mechanisms of postecdysis-associated programmed cell death of peptidergic neurons in Drosophila melanogaster.
Lee GG, Kikuno K, Nair S, Park JH. | 05/24/2014 |
| Data show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling. | Notch signaling activates Yorkie non-cell autonomously in Drosophila.
Graves HK, Woodfield SE, Yang CC, Halder G, Bergmann A., Free PMC Article | 10/6/2012 |
| dBruce inhibits apoptosis by promoting IAP-antagonist ubiquitination on unconventional acceptor sites. | Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.
Domingues C, Ryoo HD., Free PMC Article | 06/9/2012 |
| Drosophila CtBP (dCtBP) was identified as a binding partner of Diap1; whether the interaction between Diap1 and dCtBP also occurs in human cells was tested. | C-terminal binding protein-mediated transcriptional repression is regulated by X-linked inhibitor of apoptosis protein.
Lee JS, Lee SK, Youn HD, Yoo SJ. | 03/24/2012 |
| DIAP1-mediated ubiquitylation does not trigger proteasomal degradation of full-length DRONC, but serves a non-proteolytic function | Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.
Lee TV, Fan Y, Wang S, Srivastava M, Broemer M, Meier P, Bergmann A., Free PMC Article | 01/7/2012 |
| The cleaved DIAP1 binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation. | Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE.
Li X, Wang J, Shi Y. | 11/19/2011 |
| host pathway initiated by virus DNA replication and acting through instability motifs within IAP triggers IAP depletion and causes apoptosis; suggests host modulation of IAP levels is mechanism by which insects mount an apoptotic antiviral response | Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication.
Vandergaast R, Schultz KL, Cerio RJ, Friesen PD., Free PMC Article | 10/8/2011 |
| the anti-apoptotic factor drosophila inhibitor of apoptosis 1 protein is downregulated in these cells in a head involution defect protein-dependent manner | Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1.
Khammari A, Agnès F, Gandille P, Pret AM., Free PMC Article | 09/24/2011 |
| VCP binds to DIAP1 in a ubiquitin- and BIR domain-dependent manner and facilitates its degradation, therefore establishing a new link between ubiquitin, dendrite pruning and the apoptosis machinery. | Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
Rumpf S, Lee SB, Jan LY, Jan YN., Free PMC Article | 05/7/2011 |
| Results suggest that the hsromega transcripts regulate cellular levels of DIAP1 via the hnRNP Hrb57A, which physically interacts with DIAP1. | The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila.
Mallik M, Lakhotia SC., Free PMC Article | 04/19/2010 |
| found that the quantity of DIAP1 changed dramatically depending on the cell type and maturity. | Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development.
Koto A, Kuranaga E, Miura M., Free PMC Article | 01/21/2010 |
| suggest that HOW(L) enhances the sensitivity of MG cells to apoptotic signals by reducing the levels of diap1 in these cells in, demonstrating a novel mode of regulation of PCD at the mRNA level | Enhanced sensitivity of midline glial cells to apoptosis is achieved by HOW(L)-dependent repression of Diap1.
Reuveny A, Elhanany H, Volk T. | 01/21/2010 |
| Because DIAP1 prevents apoptosis after a variety of stresses, STAT92E may have a role in regulating stress responses in general | STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis.
Betz A, Ryoo HD, Steller H, Darnell JE Jr., Free PMC Article | 01/21/2010 |
| The binding of DIAP1 to dOmi resulted in DIAP1-mediated polyubiquitination of dOmi, suggesting that DIAP1 could target dOmi for proteasomal degradation. | The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.
Khan FS, Fujioka M, Datta P, Fernandes-Alnemri T, Jaynes JB, Alnemri ES., Free PMC Article | 01/21/2010 |