| LIM Zinc Finger Domain Containing 1 Risk Genotype of Recipient Is Associated with Renal Tubular Inflammation in Kidney Transplantation. | LIM Zinc Finger Domain Containing 1 Risk Genotype of Recipient Is Associated with Renal Tubular Inflammation in Kidney Transplantation.
Caliskan Y, Ozluk Y, Kurashima K, Mirioglu S, Dirim AB, Hurdogan O, Oto OA, Syn M, Nazzal M, Jain A, Edwards J, Yazici H, Lentine KL., Free PMC Article | 11/7/2024 |
| The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA. | The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA.
Li Y, Wang S, Li G, Gao C, Cui Z, Cong M, Hu J, Zhang M, Jin X, Sun H, Kong D., Free PMC Article | 04/18/2024 |
| Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Yang H, Lin L, Sun K, Zhang T, Chen W, Li L, Xie Y, Wu C, Wei Z, Yu C., Free PMC Article | 02/5/2022 |
| A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells. | A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.
Su J, Guo L, Wu C. | 12/11/2021 |
| Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly. | Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
Fukuda K, Lu F, Qin J., Free PMC Article | 08/21/2021 |
| Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons. | Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons.
Natarajaseenivasan K, Shanmughapriya S, Velusamy P, Sayre M, Garcia A, Gomez NM, Langford D., Free PMC Article | 07/24/2021 |
| MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines. | MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
Kim YC, Cutler ML., Free PMC Article | 02/20/2021 |
| PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis. | PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis.
Qian T, Liu C, Ding Y, Guo C, Cai R, Wang X, Wang R, Zhang K, Zhou L, Deng Y, Wu C, Sun Y. | 11/28/2020 |
| PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth. | PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C., Free PMC Article | 10/24/2020 |
| The PINCH-1 interacts with Smurf1, which inhibits the latter from interacting with BMPR2 and consequently suppresses BMPR2 degradation, resulting in augmented BMP signaling and MSC osteogenic differentiation (OD). | A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation.
Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, Ma J, Wu C., Free PMC Article | 05/16/2020 |
| We found that the LIMS1 locus appeared to encode a minor histocompatibility antigen. Genomic collision at this locus was associated with rejection of the kidney allograft and with production of anti-LIMS1 IgG2 and IgG3. | Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection.
Steers NJ, Li Y, Drace Z, D'Addario JA, Fischman C, Liu L, Xu K, Na YJ, Neugut YD, Zhang JY, Sterken R, Balderes O, Bradbury D, Ozturk N, Ozay F, Goswami S, Mehl K, Wold J, Jelloul FZ, Rohanizadegan M, Gillies CE, Vasilescu EM, Vlad G, Ko YA, Mohan S, Radhakrishnan J, Cohen DJ, Ratner LE, Scolari F, Susztak K, Sampson MG, Deaglio S, Caliskan Y, Barasch J, Courtney AE, Maxwell AP, McKnight AJ, Ionita-Laza I, Bakker SJL, Snieder H, de Borst MH, D'Agati V, Amoroso A, Gharavi AG, Kiryluk K., Free PMC Article | 06/1/2019 |
| High LIMS1 expression is associated with Neuroblastoma. | Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.
Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H., Free PMC Article | 10/27/2018 |
| focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease. | High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis.
Tsinias G, Nikou S, Papadas T, Pitsos P, Papadaki H, Bravou V., Free PMC Article | 10/6/2018 |
| that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer | Knockdown of PINCH-1 protein sensitizes the estrogen positive breast cancer cells to chemotherapy induced apoptosis.
Bhatia A, Muthusamy S, Giridhar K, Goel S. | 09/1/2018 |
| Mammalian cells have two functional PINCH proteins, PINCH1 and PINCH2. PINCH not only binds to Nck2 and engages in the signaling of growth factor receptors, but also forms a ternary complex with ILK and parvin (IPP complex). | Signaling via PINCH: Functions, binding partners and implications in human diseases.
Xu H, Cao H, Xiao G., Free PMC Article | 01/28/2017 |
| our data suggest an essential role of PINCH1, ILK and ILKAP for the radioresistance of p53-wildtype glioblastoma multiforme cells | ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation.
Hausmann C, Temme A, Cordes N, Eke I., Free PMC Article | 08/13/2016 |
| Data suggest that PINCH1 and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR function and downstream signaling in a cellular model of human squamous cell carcinoma. | Targeting of the EGFR/β1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures.
Rossow L, Eke I, Dickreuter E, Cordes N. | 04/2/2016 |
| Downregulation of PINCH1 is associated with metastatic breast cancer. | Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples.
Giotopoulou N, Valiakou V, Papanikolaou V, Dubos S, Athanassiou E, Tsezou A, Zacharia LC, Gkretsi V. | 05/23/2015 |
| changes in CSF levels of PINCH appear to correlate with changes in blood CD4 count and with changes in CSF hyperphosphorylated Tau levels | Changes in PINCH levels in the CSF of HIV+ individuals correlate with hpTau and CD4 count.
Adiga R, Ozdemir AY, Carides A, Wasilewski M, Yen W, Chitturi P, Ellis R, Langford D., Free PMC Article | 02/28/2015 |
| two novel genes, galectin 9 and PINCH, were expressed at much higher levels in cancerous lesions than in normal tissues in all the patients with clear-cell carcinoma who were examined | Galectin 9 and PINCH, novel immunotherapy targets of renal cell carcinoma: a rationale to find potential tumour antigens and the resulting cytotoxic T lymphocytes induced by the derived peptides.
Kawashima H, Obayashi A, Kawamura M, Masaki S, Tamada S, Iguchi T, Uchida J, Kuratsukuri K, Tanaka T, Nakatani T. | 06/7/2014 |
| PINCH predicts survival in rectal cancer patients with RT, but not in patients without RT. The expression of PINCH may be regulated by radiation and by environmental factors surrounding the cells. | PINCH expression in relation to radiation response in co-cultured colon cancer cells and in rectal cancer patients.
Holmqvist A, Holmlund B, Ardsby M, Pathak S, Sun XF. | 04/12/2014 |
| PINCH is increased and binds to hp-Tau. These studies address a new mechanism by which AD and HIV may intersect and identify PINCH as a contributing factor to the accumulation of hyperphosphorylated Tau. | PINCH in the cellular stress response to tau-hyperphosphorylation.
Ozdemir AY, Rom I, Kovalevich J, Yen W, Adiga R, Dave RS, Langford D., Free PMC Article | 10/19/2013 |
| Pinch-1 mRNA and protein were significantly up-regulated in acute lymphoblastic leukemia and acute myeloid leukemia bone marrow stromal cells compared to normal bone marrow stromal cells (p<0.01). | Pinch-1 was up-regulated in leukemia BMSC and its possible effect.
Zeng D, Hao L, Xu W, Li Z, Li W, Li J, Zhang X, Chen X, Kong P. | 07/27/2013 |
| PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma. | PINCH expression and its clinicopathological significance in gastric adenocarcinoma.
Zhu ZL, Yan BY, Zhang Y, Yang YH, Wang ZM, Zhang HZ, Wang MW, Zhang XH, Sun XF., Free PMC Article | 06/15/2013 |
| PINCH mRNA overexpression in colorectal carcinomas is correlated with VEGF and FAS mRNA expression | PINCH mRNA overexpression in colorectal carcinomas correlated with VEGF and FAS mRNA expression.
Zhang ZY, Tian YF, Wang YY, Zhang LJ, Zhao ZR, Sun XF. | 02/25/2012 |