| Dm myb and grim are both involved in regulating PCD in two distinct settings suggests that these two genes may often work together to mediate PCD. | The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin.
Rovani MK, Brachmann CB, Ramsay G, Katzen AL., Free PMC Article | 03/2/2013 |
| Study provide evidence that miR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective (hid), grim and sickle (skl). | Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.
Ge W, Chen YW, Weng R, Lim SF, Buescher M, Zhang R, Cohen SM., Free PMC Article | 08/18/2012 |
| findings demonstrate that neuroblast apoptosis during embryogenesis requires the coordinated expression of the cell death genes grim and reaper, and possibly sickle | Coordinated expression of cell death genes regulates neuroblast apoptosis.
Tan Y, Yamada-Mabuchi M, Arya R, St Pierre S, Tang W, Tosa M, Brachmann C, White K., Free PMC Article | 07/23/2011 |
| Programmed cell death of microchaete glial cells represents an exceptional opportunity to study the mitochondrial proapoptotic process induced by Grim. | grim promotes programmed cell death of Drosophila microchaete glial cells.
Wu JN, Nguyen N, Aghazarian M, Tan Y, Sevrioukov EA, Mabuchi M, Tang W, Monserrate JP, White K, Brachmann CB., Free PMC Article | 06/18/2011 |
| Rpr is able to self-associate and also binds to Hid and Grim. | Drosophila IAP antagonists form multimeric complexes to promote cell death.
Sandu C, Ryoo HD, Steller H., Free PMC Article | 10/23/2010 |
| temperature shifts and dietary restriction, which slow the rate of aging in D. melanogaster, extend the window of neuronal susceptibility to GRIM over-expression in a way that scales to lifespan. | Neuronal susceptibility to GRIM in Drosophila melanogaster measures the rate of genetic changes that scale to lifespan.
Bedoukian MA, Rodriguez SM, Cohen MB, Duncan Smith SV, Park J., Free PMC Article | 01/21/2010 |
| When Grim is overexpressed in vivo, both the N-terminal & GH3 domains are equally necessary & cooperate for apoptosis induction. The N-terminal and GH3 Grim domains activate independent apoptotic pathways that synergize to induce programmed cell death. | GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway.
Clavería C, Caminero E, Martínez-A C, Campuzano S, Torres M., Free PMC Article | 01/21/2010 |
| role in countering DrICE inhibition by DIAP1 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Yan N, Wu JW, Chai J, Li W, Shi Y. | 01/21/2010 |
| Both Grim and Hid were demonstrated to interact with Amsacta moorei Entomopoxvirus inhibitor of apoptosis (AMV-IAP) in vivo, and Grim- or Hid-induced cell death was suppressed when AMV-IAP was coexpressed. | Amsacta moorei Entomopoxvirus inhibitor of apoptosis suppresses cell death by binding Grim and Hid.
Li Q, Liston P, Schokman N, Ho JM, Moyer RW., Free PMC Article | 01/21/2010 |
| Grim is located downstream of LKB1 and is invloved in LKB1 sependent apoptosis. | JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila.
Lee JH, Koh H, Kim M, Park J, Lee SY, Lee S, Chung J. | 01/21/2010 |
| These results show that internal ribosome entry sites-dependent initiation may play a role in the translation of Drosophila proapoptotic genes and suggest a variety of regulatory pathways. | Different modes of translation for hid, grim and sickle mRNAs in Drosophila.
Vazquez-Pianzola P, Hernández G, Suter B, Rivera-Pomar R. | 01/21/2010 |
| Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death | Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death.
Vernooy SY, Chow V, Su J, Verbrugghe K, Yang J, Cole S, Olson MR, Hay BA. | 01/21/2010 |
| Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms | Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.
Yoo SJ, Huh JR, Muro I, Yu H, Wang L, Wang SL, Feldman RM, Clem RJ, Müller HA, Hay BA. | 01/21/2010 |
| Analysis of a Grim mutant that promoted XIAP degradation | Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.
Silke J, Kratina T, Ekert PG, Pakusch M, Vaux DL. | 01/21/2010 |