| Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression. | Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression.
Yu Y, Li H, Wu C, Li J. | 02/12/2022 |
| LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies. | LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies.
Hashemi M, Sarabandi S, Karami S, Śmieja J, Moazeni-Roodi A, Ghavami S, Łos MJ., Free PMC Article | 05/15/2021 |
| ASCL1 and LMO1 directly regulate the expression of CRC genes, indicating that ASCL1 is a member and LMO1 is a coregulator of the ADRN neuroblastoma core regulatory circuitry. | ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.
Wang L, Tan TK, Durbin AD, Zimmerman MW, Abraham BJ, Tan SH, Ngoc PCT, Weichert-Leahey N, Akahane K, Lawton LN, Rokita JL, Maris JM, Young RA, Look AT, Sanda T., Free PMC Article | 02/29/2020 |
| Target genes of the LMO1-regulated microRNAs and their relevant pathways may be a potential therapeutic targe | Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma.
Saeki N, Saito A, Sugaya Y, Amemiya M, Sasaki H., Free PMC Article | 12/1/2018 |
| IKZF1 rs10235796 C allele, IKZF1 rs6964969A>G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with LMO1 rs442264; rs3794012; rs4237770 | Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.
Al-Absi B, Razif MFM, Noor SM, Saif-Ali R, Aqlan M, Salem SD, Ahmed RH, Muniandy S. | 02/10/2018 |
| These results suggested that LMO1 gene rs110419 A > G polymorphism may contribute to protection against neuroblastoma | LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population.
He J, Zhong W, Zeng J, Zhu J, Zhang R, Wang F, Yang T, Zou Y, Xia H., Free PMC Article | 12/16/2017 |
| A C-to-T single nucleotide transition occurs as a somatic mutation in noncoding sequences 4 kb upstream of the transcriptional start site of the LMO1 oncogene in primary samples from patients with T-cell acute lymphoblastic leukaemia. This conforms to an APOBEC-like cytidine deaminase mutational signature and a new MYB binding site driving high levels of LMO1 expression. | APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL.
Li Z, Abraham BJ, Berezovskaya A, Farah N, Liu Y, Leon T, Fielding A, Tan SH, Sanda T, Weintraub AS, Li B, Shen S, Zhang J, Mansour MR, Young RA, Look AT., Free PMC Article | 10/28/2017 |
| LMO1 is an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination. | LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT., Free PMC Article | 09/30/2017 |
| LMO1 appears to be a coactivator of AR involved in the progression of prostate cancer | Upregulated LMO1 in prostate cancer acts as a novel coactivator of the androgen receptor.
Gu H, Liu T, Cai X, Tong Y, Li Y, Wang C, Li F. | 09/10/2016 |
| data suggest that genetic variants in LMO1 are associated with increased NB risk in Chinese children. | Candidate Gene Association Analysis of Neuroblastoma in Chinese Children Strengthens the Role of LMO1.
Lu J, Chu P, Wang H, Jin Y, Han S, Han W, Tai J, Guo Y, Ni X., Free PMC Article | 03/5/2016 |
| a polymorphism within a super-enhancer element in the first intron of LMO1 influences neuroblastoma susceptibility through differential GATA transcription factor binding and direct modulation of LMO1 expression in cis | Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, Wei JS, Khan J, Bramlett K, Rahman N, Capasso M, Iolascon A, Gerhard DS, Guidry Auvil JM, Young RA, Hakonarson H, Diskin SJ, Look AT, Maris JM., Free PMC Article | 01/16/2016 |
| LMO1 is a commonly activated tumor promoter that activates AKT signaling in non-small cell lung cancer. | LMO1 is a novel oncogene in lung cancer, and its overexpression is a new predictive marker for anti-EGFR therapy.
Zhang Y, Yang J, Wang J, Guo H, Jing N. | 05/16/2015 |
| LMO1 is a commonly activated tumor promoter that activates AKT signaling in colorectal cancer and a new predictive marker for targeted therapy. | LMO1 is a novel oncogene in colorectal cancer and its overexpression is a new predictive marker for anti-EGFR therapy.
Liu J, Yan P, Jing N, Yang J. | 01/17/2015 |
| results show that LMO1 is poised for expression in normal progenitors, where activation of SCL/TAL1 together with a breakdown of epigenetic repression of LMO1 regulatory elements | Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.
Oram SH, Thoms J, Sive JI, Calero-Nieto FJ, Kinston SJ, Schütte J, Knezevic K, Lock RB, Pimanda JE, Göttgens B., Free PMC Article | 08/10/2013 |
| genetic variants within LMO1 are associated with acute lymphoblastic leukemia and identify this gene as a strong candidate for precursor B-cell leukemogenesis. | Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1).
Beuten J, Gelfond JA, Piwkham D, Pollock BH, Winick NJ, Collier AB 3rd, Tomlinson GE. | 10/29/2011 |
| data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression | Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Wang K, Diskin SJ, Zhang H, Attiyeh EF, Winter C, Hou C, Schnepp RW, Diamond M, Bosse K, Mayes PA, Glessner J, Kim C, Frackelton E, Garris M, Wang Q, Glaberson W, Chiavacci R, Nguyen L, Jagannathan J, Saeki N, Sasaki H, Grant SF, Iolascon A, Mosse YP, Cole KA, Li H, Devoto M, McGrady PW, London WB, Capasso M, Rahman N, Hakonarson H, Maris JM., Free PMC Article | 02/26/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
Karasik D, Hsu YH, Zhou Y, Cupples LA, Kiel DP, Demissie S., Free PMC Article | 04/7/2010 |
| The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis. | GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling.
Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara K, Tamura M, Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H. | 01/21/2010 |
| 60% of transgenic mice that overexpressed both OLIG2 and LMO1 developed pre-T lymphoblastic lymphoma/leukemia with large thymic tumor masses. | OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.
Lin YW, Deveney R, Barbara M, Iscove NN, Nimer SD, Slape C, Aplan PD., Free PMC Article | 01/21/2010 |