| Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2. | Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2.
Ge J, Yue Y, Nie HY, Liu KG, Li H, Lin HG, Zhang T, Yan HF, Sun HW, Yang JW, Zhou JL, Cui Y. | 02/1/2024 |
| LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1. | LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1.
Lu L, Wang J, Fang F, Guo A, Jiang S, Tao Y, Zhang Y, Li Y, Zhang K, Zhang Z, Zhuo R, Chu X, Li X, Tian Y, Ma L, Sang X, Chen Y, Yu J, Yang Y, Cao H, Gao J, Lu J, Hu S, Pan J, He H., Free PMC Article | 10/20/2023 |
| Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell Lymphoma. | Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell Lymphoma.
Berker N, Yeğen G, Özlük Y, Doğan Ö., Free PMC Article | 09/1/2023 |
| PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1. | PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1.
Pan X, Liu D, Ying M, Zheng G, Fan C, Pan F, Ke Q. | 03/16/2023 |
| Potential link of single nucleotide polymorphisms within LMO2 to the risk of cervical squamous-cell carcinoma in Chinese populations. | Potential link of single nucleotide polymorphisms within LMO2 to the risk of cervical squamous-cell carcinoma in Chinese populations.
Wang H, Wang J, Li R, Zhu Z. | 02/9/2023 |
| LMO2 expression is frequent in T-lymphoblastic leukemia and correlates with survival, regardless of T-cell stage. | LMO2 expression is frequent in T-lymphoblastic leukemia and correlates with survival, regardless of T-cell stage.
Latchmansingh KA, Wang X, Verdun RE, Marques-Piubelli ML, Vega F, You MJ, Chapman J, Lossos IS., Free PMC Article | 09/3/2022 |
| LMO2 plays differential roles in trophoblast subtypes and is associated with preeclampsia. | LMO2 plays differential roles in trophoblast subtypes and is associated with preeclampsia.
Chen Y, Meng Y, Yu Y, Li W, Shen Y, Li S, Chang Y, Sun W. | 04/16/2022 |
| Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland. | Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland.
Sheng D, Zhang Y, Xue T, Zhou XY, Li XQ., Free PMC Article | 04/16/2022 |
| Lack of expression of LMO2 clone SP51 identifies MYC rearrangements in aggressive large B-cell lymphomas. | Lack of expression of LMO2 clone SP51 identifies MYC rearrangements in aggressive large B-cell lymphomas.
Vazquez I, Papaleo N, Lop J, Puiggros A, Sanchez-Gonzalez B, Diez-Feijoo R, Gimeno E, Andrade-Campos M, Salar A, Espinet B, Salido M, Tapia G, Carreras J, Ferrer A, Arenillas L, Calvo X, Colomo L. | 01/22/2022 |
| MiR-223 Suppresses Proliferation and Promotes Apoptosis of Diffuse Large B-Cell Lymphoma Cells Through Lmo2 and MAPK Signaling Pathway. | MiR-223 Suppresses Proliferation and Promotes Apoptosis of Diffuse Large B-Cell Lymphoma Cells Through Lmo2 and MAPK Signaling Pathway.
Zhang Y, Zhang J. | 12/18/2021 |
| Low LIM-domain only 2 (LMO2) expression in aggressive B cell lymphoma correlates with MYC and MYC/BCL2 rearrangements, especially in germinal center cell-type tumors. | Low LIM-domain only 2 (LMO2) expression in aggressive B cell lymphoma correlates with MYC and MYC/BCL2 rearrangements, especially in germinal center cell-type tumors.
Chapman J, Verdun RE, Lossos IS., Free PMC Article | 11/6/2021 |
| LMO2 upregulation due to AR deactivation in cancer-associated fibroblasts induces non-cell-autonomous growth of prostate cancer after androgen deprivation. | LMO2 upregulation due to AR deactivation in cancer-associated fibroblasts induces non-cell-autonomous growth of prostate cancer after androgen deprivation.
Chen L, Wang YY, Li D, Wang C, Wang SY, Shao SH, Zhu ZY, Zhao J, Zhang Y, Ruan Y, Han BM, Xia SJ, Jiang CY, Zhao FJ. | 08/7/2021 |
| Biochemical Feature of LMO2 Interactome and LMO2 Function Prospect. | Biochemical Feature of LMO2 Interactome and LMO2 Function Prospect.
Wang W, Chen Y, Chang Y, Sun W., Free PMC Article | 05/22/2021 |
| FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK. | FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK.
Chen PC, Hsueh YW, Lee YH, Tsai HW, Tsai KJ, Chiang PM., Free PMC Article | 04/3/2021 |
| our data suggest that Zeb2 and Lmo2 drive malignant transformation of immature T-cell progenitors via distinct molecular mechanisms. | ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms.
Goossens S, Wang J, Tremblay CS, De Medts J, T'Sas S, Nguyen T, Saw J, Haigh K, Curtis DJ, Van Vlierberghe P, Berx G, Taghon T, Haigh JJ., Free PMC Article | 06/20/2020 |
| Study demonstrates that in diffuse large B cell lymphomas LMO2 controls DNA double-strand break (DSB) pathway choice, resulting in homologous recombination dysfunction and tumor cell sensitization to genotoxic agents that could be further enhanced with PARP1/2 inhibitors. Mechanistically, LMO2 inhibits BRCA1 recruitment to DSBs by interacting with 53BP1 during repair. | LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.
Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS., Free PMC Article | 05/23/2020 |
| Study presents genetic evidence that the development of Wilms tumors in WAGR syndrome patients should be attributed to the deletion of WT1 and LMO2 rather than WT1 only. | LMO2 gene deletions significantly worsen the prognosis of Wilms' tumor development in patients with WAGR syndrome.
Marakhonov AV, Vasilyeva TA, Voskresenskaya AA, Sukhanova NV, Kadyshev VV, Kutsev SI, Zinchenko RA. | 05/16/2020 |
| Lysine deacetylation of LMO2 is essential for the LDB1 interaction and transcriptional activity of the TAL1 complex. | LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.
Morishima T, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Hähnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Müller P, Bajoghli B, Skokowa J., Free PMC Article | 02/1/2020 |
| Our findings reveal a previously unidentified mechanism, by which PML-RARalpha interferes with erythropoiesis through directly targeting and transrepressing LMO2 expression in the development of acute myeloid leukaemia (AML). | PML-RARα interferes with erythropoiesis by repressing LMO2 in acute promyelocytic leukaemia.
Yang X, Tan Y, Wang P, Zhang H, Zhao M, Zhao X, Wang K., Free PMC Article | 11/2/2019 |
| these data helped drawing a roughly dynamic LMO2 regulatory procedure during hematopoiesis, suggested diversified transcriptional regulation patterns of LMO2 in different hematopoietic lineages and could partially explain the lineage-specific, differentially functional performance of LMO2 in hematopoietic system. | LMO2 functional and transcriptional regulatory profiles in hematopoietic cells.
Wu C, Yuan M, Gao Y, Sun W. | 06/8/2019 |
| the data in this study revealed a novel crosstalk between LMO2 and the Wnt signaling pathway during tumorigenesis and suggested that LMO2 might be a tumor suppressor in certain solid tumors. | LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer.
Liu Y, Huang D, Wang Z, Wu C, Zhang Z, Wang D, Li Z, Zhu T, Yang S, Sun W., Free PMC Article | 05/5/2018 |
| LMO2 has a predominantly cytoplasmic location in breast cancer cells. LMO2 interaction with cofilin1 regulates actin cytoskeleton dynamics, promoting tumor cell invasion and metastasis. | LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling.
Liu Y, Wang Z, Huang D, Wu C, Li H, Zhang X, Meng B, Li Z, Zhu T, Yang S, Sun W., Free PMC Article | 02/24/2018 |
| These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development. | Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels.
Miyashita K, Kitajima K, Goyama S, Kitamura T, Hara T. | 02/17/2018 |
| stromal LMO2 may be responsible for zonal characteristic of Prostate cancer | LIM domain only 2 over-expression in prostate stromal cells facilitates prostate cancer progression through paracrine of Interleukin-11.
Jiang CY, Yu JJ, Ruan Y, Wang XH, Zhao W, Wang XJ, Zhu YP, Gao Y, Hao KY, Chen L, Han BM, Xia SJ, Zhao FJ., Free PMC Article | 01/13/2018 |
| The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro. | LIM Domain Only 2 Regulates Endothelial Proliferation, Angiogenesis, and Tissue Regeneration.
Meng S, Matrone G, Lv J, Chen K, Wong WT, Cooke JP., Free PMC Article | 12/23/2017 |