| LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation. | LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation.
Reid KM, Brown GC., Free PMC Article | 12/5/2023 |
| Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity. | Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity.
Wagner MC, Sandoval RM, Yadav SPS, Campos SB, Rhodes GJ, Phillips CL, Molitoris BA., Free PMC Article | 06/1/2023 |
| The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity. | The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity.
Podgórska D, Cieśla M, Majdan M, Podgórski R, Kolarz B. | 11/12/2022 |
| Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry. | Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry.
Großkopf H, Vogel S, Müller CD, Köhling S, Dürig JN, Möller S, Schnabelrauch M, Rademann J, Hempel U, von Bergen M, Schubert K. | 01/1/2022 |
| Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors. | Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors.
Marakasova E, Olivares P, Karnaukhova E, Chun H, Hernandez NE, Kurasawa JH, Hassink GU, Shestopal SA, Strickland DK, Sarafanov AG., Free PMC Article | 08/28/2021 |
| Rhegmatogenous Retinal Detachment in Nonsyndromic High Myopia Associated with Recessive Mutations in LRPAP1. | Rhegmatogenous Retinal Detachment in Nonsyndromic High Myopia Associated with Recessive Mutations in LRPAP1.
Magliyah MS, Alsulaiman SM, Nowilaty SR, Alkuraya FS, Schatz P. | 03/13/2021 |
| LRPAP1 can be used for a novel therapeutic approach that targets mantle cell lymphomas with LRPAP1-reactive BCRs with high specificity | LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting.
Thurner L, Hartmann S, Fadle N, Kemele M, Bock T, Bewarder M, Regitz E, Neumann F, Nimmesgern A, von Müller L, Pott C, Kim YJ, Bohle RM, Wasik M, Schuster SJ, Hansmann ML, Preuss KD, Pfreundschuh M. | 06/1/2019 |
| data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor | High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.
Prasad JM, Young PA, Strickland DK., Free PMC Article | 05/13/2017 |
| The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene. | Clinical Characterization of LRPAP1-Related Pediatric High Myopia.
Khan AO, Aldahmesh MA, Alkuraya FS. | 06/11/2016 |
| The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3's binding to GTP was not. | Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosis.
Ruete MC, Lucchesi O, Bustos MA, Tomes CN., Free PMC Article | 04/11/2015 |
| The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE epsilon4 allelic variant. | APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease.
Singh NK, Banerjee BD, Bala K, Mitrabasu, Dung Dung AA, Chhillar N. | 02/14/2015 |
| RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells. | Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells.
Sengul S, Erturk S, Khan AM, Batuman V., Free PMC Article | 05/3/2014 |
| Mutations in LRPAP1 are associated with severe myopia in humans. | Mutations in LRPAP1 are associated with severe myopia in humans.
Aldahmesh MA, Khan AO, Alkuraya H, Adly N, Anazi S, Al-Saleh AA, Mohamed JY, Hijazi H, Prabakaran S, Tacke M, Al-Khrashi A, Hashem M, Reinheckel T, Assiri A, Alkuraya FS., Free PMC Article | 12/21/2013 |
| Data indicate that the region of complement-type repeats 2-5 in LDLR was identified as the binding site for FVIII and for alpha-2-macroglobulin receptor-associated protein (RAP). | Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII.
Kurasawa JH, Shestopal SA, Karnaukhova E, Struble EB, Lee TK, Sarafanov AG., Free PMC Article | 11/16/2013 |
| LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD. | Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.
Bruno E, Quattrocchi G, Nicoletti A, Le Pira F, Maci T, Mostile G, Andreoli V, Quattrone A, Zappia M. | 12/11/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB. | 06/30/2010 |
| Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta. | Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.
Kanekiyo T, Bu G., Free PMC Article | 01/25/2010 |
| Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias. | LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia.
Pandey P, Pradhan S, Mittal B, Pandey P, Pradhan S, Mittal B. | 01/21/2010 |
| Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma | Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility.
Pandey SN, Dixit M, Choudhuri G, Mittal B, Pandey SN, Dixit M, Choudhuri G, Mittal B. | 01/21/2010 |
| Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. | Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
Juzyszyn Z, Kurzawski M, Modrzejewski A, Sulikowski T, Pawlik A, Czerny B, Droździk M, Juzyszyn Z, Kurzawski M, Modrzejewski A, Sulikowski T, Pawlik A, Czerny B, Droździk M. | 01/21/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | See all PubMed (2) articlesACE and LRPAP1 insertion-deletion polymorphisms in a northern Ivory Coast population.
Santovito A, Burgarello C, Caravatti GA, Ouattará M, Cervella P, Pisano G, Salvarani B, Delpero M. Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a northern Italian population.
Santovito A, Bulgarello C, Cervella P, Bigatti MP, Delpero M. | 03/13/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease.
Depboylu C, Lohmüller F, Du Y, Riemenschneider M, Kurz A, Gasser T, Müller U, Dodel RC. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (14) articlesCholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.
Xu HL, Cheng JR, Andreotti G, Gao YT, Rashid A, Wang BS, Shen MC, Chu LW, Yu K, Hsing AW. Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia.
Pandey P, Pradhan S, Mittal B, Pandey P, Pradhan S, Mittal B. Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin.
Lisi S, Botta R, Pinchera A, Di Cosmo C, Perri A, De Marco G, Menconi F, Marinò M, Lisi S, Botta R, Pinchera A, Di Cosmo C, Perri A, De Marco G, Menconi F, Marinò M. Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility.
Pandey SN, Dixit M, Choudhuri G, Mittal B, Pandey SN, Dixit M, Choudhuri G, Mittal B. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
Juzyszyn Z, Kurzawski M, Modrzejewski A, Sulikowski T, Pawlik A, Czerny B, Droździk M, Juzyszyn Z, Kurzawski M, Modrzejewski A, Sulikowski T, Pawlik A, Czerny B, Droździk M. Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study.
Dixit M, Choudhuri G, Mittal B. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease.
Dixit M, Choudhuri G, Keshri LJ, Mittal B. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis.
Cunningham N, Laffan MA, Manning RA, O'Donnell JS. Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.
González P, Alvarez R, Reguero JR, Batalla A, Alvarez V, Cortina A, Cubero GI, García-Castro M, Coto E. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects.
Hashim Y, Shepherd D, Wiltshire S, Holman RR, Levy JC, Clark A, Cull CA. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease.
Sánchez L, Alvarez V, González P, González I, Alvarez R, Coto E. | 03/13/2008 |
| LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells. | Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.
Wilhelmus MM, Otte-Höller I, van Triel JJ, Veerhuis R, Maat-Schieman ML, Bu G, de Waal RM, Verbeek MM., Free PMC Article | 01/21/2010 |
| alterations of the RAP gene are not a common cause of hypothyroidism | Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin.
Lisi S, Botta R, Pinchera A, Di Cosmo C, Perri A, De Marco G, Menconi F, Marinò M, Lisi S, Botta R, Pinchera A, Di Cosmo C, Perri A, De Marco G, Menconi F, Marinò M. | 01/21/2010 |