| Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin. | Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin.
Guo Z, Huang J, Huo X, Huang C, Yu X, Sun Y, Li Y, He T, Guo H, Yang J, Xue L. | 10/23/2024 |
| Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis. | Inhibition of Leukotriene A(4) Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis.
Wu X, Sun AR, Crawford R, Xiao Y, Wang Y, Prasadam I, Mao X., Free PMC Article | 07/15/2024 |
| LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets. | LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets.
Ren T, Wang S, Zhang B, Zhou W, Wang C, Zhao X, Feng J., Free PMC Article | 03/21/2023 |
| Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis. | Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis.
Kumar SS, Solomon R, Gautam P, Inbaraj LR, Sivadasan A, Michael JS, Karthik R, Varghese GM, Christudass CS, Samuel P, Manesh A., Free PMC Article | 03/13/2023 |
| Clinical Implications of LTA4H Genetic Polymorphism in Patients with Chronic Obstructive Pulmonary Disease. | Clinical Implications of LTA(4)H Genetic Polymorphism in Patients with Chronic Obstructive Pulmonary Disease.
Zhao Y, Xu M, Liu M, Zhang Q, Xiong W. | 05/7/2022 |
| LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis. | LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis.
Siddiqi OK, Ghebremichael M, Musukuma K, Dang X, Mubanga E, Birbeck GL, Love S, Buback C, Kosloff B, Ayles H, Atadzhanov M, Koralnik IJ. | 12/11/2021 |
| Leukotriene A4 Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy. | Leukotriene A(4) Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy.
Ma TT, Cao MD, Yu RL, Shi HY, Yan WJ, Liu JG, Pan C, Sun J, Wei QY, Wang DY, Wei JF, Wang XY, Yin JS., Free PMC Article | 05/22/2021 |
| Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking. | Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking.
Audat SA, Al-Shar'i NA, Al-Oudat BA, Bryant-Friedrich A, Bedi MF, Zayed AL, Al-Balas QA., Free PMC Article | 02/20/2021 |
| the identification of FSCN1-binding partners enhances understanding of the mechanism of FSCN1-mediated malignant phenotypes, and these findings indicate that FSCN1 binds to AIMP1 and LTA4H might promote the progression of laryngeal squamous cell carcinoma . | Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1-Binding Proteins in Laryngeal Squamous Cell Carcinoma.
Gao W, An C, Xue X, Zheng X, Niu M, Zhang Y, Liu H, Zhang C, Lu Y, Cui J, Zhao Q, Wen S, Thorne RF, Zhang X, Wu Y, Wang B. | 06/27/2020 |
| Gliotoxin suppresses the biosynthesis of the potent neutrophil chemoattractant LTB4 by direct interference with LTA4H thereby impairing neutrophil functions in invasive aspergillosis. | Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B(4) Formation through Inhibition of Leukotriene A(4) Hydrolase.
König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O. | 02/1/2020 |
| Low LTA4H expression is associated with antidiastole of tuberculous pleural effusion. | Potential biomarkers for antidiastole of tuberculous and malignant pleural effusion by proteome analysis.
Shi J, Li P, Zhou L, Qi S, Wang B, Li D, Duan L, Chen WX, Xia J, Zou L, Yang S. | 01/11/2020 |
| the current study demonstrates the ability of eosinophils to express LTA4H and generate LTB4 in response to their activation. Eosinophil derived LTB4 likely contributes to the presence and severity of inflammation in asthma, in particular, those presentations characterized by prominent eosinophilia (and a paucity of neutrophils). | Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma.
Pal K, Feng X, Steinke JW, Burdick MD, Shim YM, Sung SS, Teague WG, Borish L., Free PMC Article | 12/21/2019 |
| The T allele of LTA4H gene SNP (rs17525495) is a risk factor for Crohn's disease instead of intestinal tuberculosis. | The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn's Disease instead of Intestinal Tuberculosis in a Chinese Han Population.
Yu ZQ, Wang WF, Zhu CZ, Zhang KH, Chen XC, Chen JY., Free PMC Article | 08/31/2019 |
| LTA4H is the major Pro-Gly-Pro degrading enzyme in human blood. | Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Numao S, Hasler F, Laguerre C, Srinivas H, Wack N, Jäger P, Schmid A, Osmont A, Röthlisberger P, Houguenade J, Bergsdorf C, Dawson J, Carte N, Hofmann A, Markert C, Hardaker L, Billich A, Wolf RM, Penno CA, Bollbuck B, Miltz W, Röhn TA., Free PMC Article | 07/6/2019 |
| We found no convincing association between SNPs in ALOX5 (rs12264801) or LTA4H (rs2072512 and rs2540477) and myocardial infarction | Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.
Li Y, Xu X, Zhang D, Cheng W, Zhang Y, Yu B, Zhang Y., Free PMC Article | 06/1/2019 |
| The structures reveal that a single catalytic water is involved in both catalytic activities of LTA4H, alternating between epoxide ring opening and peptide bond hydrolysis, assisted by E271 and E296, respectively. Moreover, we have found two conformations of LTA4H, uncovering significant domain movements. | Capturing LTA(4) hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB(4) synthesis.
Stsiapanava A, Samuelsson B, Haeggström JZ., Free PMC Article | 06/9/2018 |
| A higher incidence of severe IRIS among patients with mutant LTA4H genotypes (CT and TT) was observed compared to the wild type, despite similar IRIS incidence and immune restoration in both groups. Steroids were effective in alleviating IRIS in all the genotypes | Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV.
Narendran G, Kavitha D, Karunaianantham R, Gil-Santana L, Almeida-Junior JL, Reddy SD, Kumar MM, Hemalatha H, Jayanthi NN, Ravichandran N, Krishnaraja R, Prabhakar A, Manoharan T, Nithyananthan L, Arjunan G, Natrajan M, Swaminathan S, Andrade BB., Free PMC Article | 08/12/2017 |
| LTA4H genotype predicted survival of HIV-uninfected patients, with TT-genotype patients significantly more likely to survive tuberculous meningitis than CC-genotype patients. LTA4H genotype and HIV infection influence pretreatment inflammatory phenotype and survival from tuberculous meningitis. LTA4H genotype may predict adjunctive corticosteroid responsiveness in HIV-uninfected individuals. | Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.
Thuong NTT, Heemskerk D, Tram TTB, Thao LTP, Ramakrishnan L, Ha VTN, Bang ND, Chau TTH, Lan NH, Caws M, Dunstan SJ, Chau NVV, Wolbers M, Mai NTH, Thwaites GE., Free PMC Article | 06/24/2017 |
| The LTA4H promoter polymorphism correlated with CSF mononuclear cell count but not with mortality in tuberculous meningitis | Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia.
van Laarhoven A, Dian S, Ruesen C, Hayati E, Damen MSMA, Annisa J, Chaidir L, Ruslami R, Achmad TH, Netea MG, Alisjahbana B, Rizal Ganiem A, van Crevel R. | 06/24/2017 |
| LTA4H promoter region SNP was associated with susceptibility to bacteriologically confirmed bacterial meningitis but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.
Dunstan SJ, Tram TT, Thwaites GE, Chau TT, Phu NH, Hien TT, Farrar JJ, Wolbers M, Mai NT., Free PMC Article | 03/5/2016 |
| Report no association between LTA4H SNPs and atherosclerotic plaque phenotypes. | Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.
van der Laan SW, Foroughi Asl H, van den Borne P, van Setten J, van der Perk ME, van de Weg SM, Schoneveld AH, de Kleijn DP, Michoel T, Björkegren JL, den Ruijter HM, Asselbergs FW, de Bakker PI, Pasterkamp G. | 12/19/2015 |
| The best proteinogenic amino acid recognized by LTA4H is arginine. | A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.
Byzia A, Haeggström JZ, Salvesen GS, Drag M., Free PMC Article | 01/3/2015 |
| The results of our study failed to confirm whether the selected variants in LTA4H gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA. | Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes.
Rosiak M, Postula M, Kaplon-Cieslicka A, Kondracka A, Trzepla E, Zaremba M, Filipiak KJ, Kosior DA, Czlonkowski A, Opolski G, Janicki PK. | 04/12/2014 |
| The LTA4H A-9188>G polymorphism has a strong association with severe asthma in children. | Can certain genotypes predispose to poor asthma control in children? A pharmacogenetic study of 9 candidate genes in children with difficult asthma.
Almomani B, Hawwa AF, Millership JS, Heaney L, Douglas I, McElnay JC, Shields MD., Free PMC Article | 10/26/2013 |
| Data indicate that 13S,14S-epoxy-docosahexaenoic acid (DHA) inhibits leukotriene B4 (LTB4) biosynthesis by leukotriene A4 hydrolase (LTA4H). | The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.
Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN., Free PMC Article | 09/21/2013 |