| Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes. | Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes.
Sanchez-Pupo RE, O'Donnell BL, Johnston D, Gyenis L, Litchfield DW, Penuela S., Free PMC Article | 04/23/2022 |
| Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells. | Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.
Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, Størling J. | 11/25/2017 |
| It used overlap-extension cloning to create the first chimeric Panx, consisting of Panx2 with the Panx1 C-terminus (Panx2(Panx1CT)), to determine whether the Panx1 C-terminus influences the trafficking of Panx2. | Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization.
Wicki-Stordeur LE, Boyce AK, Swayne LA. | 11/8/2014 |
| ). Pannexin double-knockout mice (Px1(-/-) Px2(-/-)) were less impaired in parameters such as exploration, anxiety, sensorimotor function and behavioral symmetry. | Functional outcome of pannexin-deficient mice after cerebral ischemia.
Bargiotas P, Krenz A, Monyer H, Schwaninger M., Free PMC Article | 08/3/2013 |
| In situ hybridization revealed that mRNAs for Panx1 and Panx2 were both expressed in the olfactory epithelium and olfactory bulb. | Patterns of heterogeneous expression of pannexin 1 and pannexin 2 transcripts in the olfactory epithelium and olfactory bulb.
Zhang H, Chen Y, Zhang C. | 05/4/2013 |
| Px1 and Px2 underlie channel function in neurons and contribute to ischemic brain damage | Pannexins in ischemia-induced neurodegeneration.
Bargiotas P, Krenz A, Hormuzdi SG, Ridder DA, Herb A, Barakat W, Penuela S, von Engelhardt J, Monyer H, Schwaninger M., Free PMC Article | 03/10/2012 |
| Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment | Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment.
Swayne LA, Sorbara CD, Bennett SA., Free PMC Article | 09/27/2010 |
| Panx2 strongly interacts with the core and high-mannose species of Panx1 but not with Panx3. The combination of Panx1 & Panx2 results in compromised channel function. | Glycosylation regulates pannexin intermixing and cellular localization.
Penuela S, Bhalla R, Nag K, Laird DW., Free PMC Article | 04/12/2010 |
| Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions. | Identification and characterization of pannexin expression in the mammalian cochlea.
Wang XH, Streeter M, Liu YP, Zhao HB., Free PMC Article | 01/21/2010 |
| Data show that Panx2 is expressed in the spiral and Scarpa's ganglion neurons. | Pannexins are new molecular candidates for assembling gap junctions in the cochlea.
Tang W, Ahmad S, Shestopalov VI, Lin X., Free PMC Article | 01/21/2010 |
| Despite similarity in detergent solubility of pannexins and connexins, the lack of spatial co-localization in the lens membranes suggested a distinct, non-redundant to connexin function for these proteins in the lens cell membrane. | Molecular characterization of pannexins in the lens.
Dvoriantchikova G, Ivanov D, Pestova A, Shestopalov V. | 01/21/2010 |
| Results reveal a widespread and similar mRNA distribution for both pannexin 1 and 2, but indicate that they are inversely regulated during the development of the rat brain. | Pannexin1 and Pannexin2 expression in the developing and mature rat brain.
Vogt A, Hormuzdi SG, Monyer H. | 01/21/2010 |
| Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons | Expression of pannexin family of proteins in the retina.
Dvoriantchikova G, Ivanov D, Panchin Y, Shestopalov VI. | 01/21/2010 |