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    MIRLET7C microRNA let-7c [ Homo sapiens (human) ]

    Gene ID: 406885, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Let-7c-5p Down Regulates the Proliferation of Colorectal Cancer Through the MAPK-ERK-Signaling Pathway.

    Let-7c-5p Down Regulates the Proliferation of Colorectal Cancer Through the MAPK-ERK-Signaling Pathway.
    Fu J, Zhou L, Li S, He W, Zheng J, Hou Z, He P.

    09/9/2024
    IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1alpha pathway.

    IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1α pathway.
    Guo QY, Song JN, Chen YM, Yuan HN, Xue WS, Sun Y, Niu XL, Wang Y, Chen X.

    07/16/2024
    MicroRNA let-7c-5p Alleviates in Hepatocellular Carcinoma by Targeting Enhancer of Zeste Homolog 2: A Study Intersecting Bioinformatic Analysis and Validated Experiments.

    MicroRNA let-7c-5p Alleviates in Hepatocellular Carcinoma by Targeting Enhancer of Zeste Homolog 2: A Study Intersecting Bioinformatic Analysis and Validated Experiments.
    Lin T, Guo X, Du Q, Liu W, Zhong X, Wang S, Cao L.

    03/21/2024
    Exosomal miR-let-7c-5p is involved in the cognitive function of type 2 diabetes mellitus patients by interleukin 10: A cross-sectional study.

    Exosomal miR-let-7c-5p is involved in the cognitive function of type 2 diabetes mellitus patients by interleukin 10: A cross-sectional study.
    Zhang H, Yang S, Zhu W, Niu T, Wang J, Yang M, Liu E, Wang J, Li S, Zhang H., Free PMC Article

    12/18/2023
    MicroRNA Let-7 Induces M2 Macrophage Polarization in COPD Emphysema Through the IL-6/STAT3 Pathway.

    MicroRNA Let-7 Induces M2 Macrophage Polarization in COPD Emphysema Through the IL-6/STAT3 Pathway.
    Liu T, Zhang Z, Shen W, Wu Y, Bian T., Free PMC Article

    08/10/2023
    RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway.

    RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway.
    Wang C, Xue H, Zhao R, Sun Z, Gao X, Qi Y, Wang H, Xu J, Deng L, Li G.

    03/30/2023
    Let-7c-5p Represses Cisplatin Resistance of Lung Adenocarcinoma Cells by Targeting CDC25A.

    Let-7c-5p Represses Cisplatin Resistance of Lung Adenocarcinoma Cells by Targeting CDC25A.
    Huang L, Lou K, Wang K, Liang L, Chen Y, Zhang J.

    02/16/2023
    Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma.

    Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma.
    Chen W, Wang H, Shen Y, Wang S, Liu D, Zhao H, Wang G, Huang F, Wang W, Wu R, Hou L, Ye Z, Zhang X, Geng X, Yu X.

    02/13/2023
    Down-Regulation of circulating miR-23a-3p, miR-101-3p, and miR-let-7c in Women with Idiopathic Recurrent Pregnancy Loss.

    Down-Regulation of circulating miR-23a-3p, miR-101-3p, and miR-let-7c in Women with Idiopathic Recurrent Pregnancy Loss.
    Tutunfroush M, Ghorbian S, Mohseni J, Danaii S, Rad MG.

    10/22/2022
    Targeting Castration-Resistant Prostate Cancer Using Mesenchymal Stem Cell Exosomes for Therapeutic MicroRNA-let-7c Delivery.

    Targeting Castration-Resistant Prostate Cancer Using Mesenchymal Stem Cell Exosomes for Therapeutic MicroRNA-let-7c Delivery.
    Kurniawati I, Liu MC, Hsieh CL, Do AD, Sung SY.

    10/22/2022
    Hsa-let-7c-5p, hsa-miR-130b-3p, and hsa-miR-142-3p as Novel miRNA Biomarkers for Melanoma Progression.

    Hsa-let-7c-5p, hsa-miR-130b-3p, and hsa-miR-142-3p as Novel miRNA Biomarkers for Melanoma Progression.
    Wu X, Wang Y, Chen C, Xue Y, Zheng S, Cai L., Free PMC Article

    08/6/2022
    Exosomes of A549 Cells Induced Migration, Invasion, and EMT of BEAS-2B Cells Related to let-7c-5p and miR-181b-5p.

    Exosomes of A549 Cells Induced Migration, Invasion, and EMT of BEAS-2B Cells Related to let-7c-5p and miR-181b-5p.
    Liu Y, Su CY, Yan YY, Wang J, Li JJ, Fu JJ, Wang YQ, Zhang JY., Free PMC Article

    08/6/2022
    Profiling of circulating chromosome 21-encoded microRNAs, miR-155, and let-7c, in down syndrome.

    Profiling of circulating chromosome 21-encoded microRNAs, miR-155, and let-7c, in down syndrome.
    Pérez-Villarreal JM, Aviña-Padilla K, Beltrán-López E, Guadrón-Llanos AM, López-Bayghen E, Magaña-Gómez J, Meraz-Ríos MA, Varela-Echavarría A, Angulo-Rojo C., Free PMC Article

    06/25/2022
    Can increased expression of miR-Let-7c reduce the transition potential of high-grade urothelial carcinoma?

    Can increased expression of miR-Let-7c reduce the transition potential of high-grade urothelial carcinoma?
    da Silva Gomes PR, Candido P, Ghazarian V, Camargo JA, Guimarães VR, Gonçalves GL, Romão P, Silva IA, Srougi M, Nahas WC, Leite KR, Reis ST, Pimenta R, Viana NI.

    03/5/2022
    Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients.

    Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients.
    Minin EOZ, Paim LR, Lopes ECP, Bueno LCM, Carvalho-Romano LFRS, Marques ER, Vegian CFL, Pio-Magalhães JA, Coelho-Filho OR, Sposito AC, Matos-Souza JR, Nadruz W, Schreiber R., Free PMC Article

    01/15/2022
    Slow Transcription of the 99a/let-7c/125b-2 Cluster Results in Differential MiRNA Expression and Promotes Melanoma Phenotypic Plasticity.

    Slow Transcription of the 99a/let-7c/125b-2 Cluster Results in Differential MiRNA Expression and Promotes Melanoma Phenotypic Plasticity.
    Sheinboim D, Parikh S, Parikh R, Menuchin A, Shapira G, Kapitansky O, Elkoshi N, Ruppo S, Shaham L, Golan T, Elgavish S, Nevo Y, Bell RE, Malcov-Brog H, Shomron N, Taub JW, Izraeli S, Levy C.

    12/11/2021
    Long noncoding RNA MIR4713HG aggravates malignant behaviors in oral tongue squamous cell carcinoma via binding with microRNA let7c5p.

    Long non‑coding RNA MIR4713HG aggravates malignant behaviors in oral tongue squamous cell carcinoma via binding with microRNA let‑7c‑5p.
    Jia B, Zheng X, Qiu X, Jiang X, Liu J, Huang Z, Xiang S, Chen G, Zhao J., Free PMC Article

    11/13/2021
    Circulating miR-155, let-7c, miR-21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer.

    Circulating miR-155, let-7c, miR-21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer.
    Aksan H, Kundaktepe BP, Sayili U, Velidedeoglu M, Simsek G, Koksal S, Gelisgen R, Yaylim I, Uzun H.

    10/2/2021
    Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment.

    Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment.
    Tian X, Sun M, Wu H, Chen C, Li H, Qiu S, Wang T, Han J, Xiao Q, Chen K.

    08/28/2021
    miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts.

    miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts.
    Law YY, Lee WF, Hsu CJ, Lin YY, Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF., Free PMC Article

    07/31/2021
    MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.

    MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.
    Sato I, Ishibashi M, Tokunaga H, Shigeta S, Sakurada S, Shimada M, Nagase S, Watanabe Y, Yaegashi N.

    06/12/2021
    Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma.

    Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma.
    Wang L, Li J, Li Y, Pang LB.

    05/29/2021
    Association of miR-125b, miR-17 and let-7c Dysregulations With Response to Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With Metastatic Colorectal Cancer.

    Association of miR-125b, miR-17 and let-7c Dysregulations With Response to Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With Metastatic Colorectal Cancer.
    Fiala O, Sorejs O, Hosek P, Liska V, Vycital O, Bruha J, Kucera R, Topolcan O, Finek J, Maceckova D, Pitule P., Free PMC Article

    05/8/2021
    Let-7c-5p Is Involved in Chronic Kidney Disease by Targeting TGF-beta Signaling.

    Let-7c-5p Is Involved in Chronic Kidney Disease by Targeting TGF-β Signaling.
    Wang Z, Zhou C, Sun Y, Chen Y, Xue D., Free PMC Article

    04/3/2021
    Let-7c regulated epithelial-mesenchymal transition leads to osimertinib resistance in NSCLC cells with EGFR T790M mutations.

    Let-7c regulated epithelial-mesenchymal transition leads to osimertinib resistance in NSCLC cells with EGFR T790M mutations.
    Li XF, Shen WZ, Jin X, Ren P, Zhang J., Free PMC Article

    12/26/2020
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