| Study shows that meiotic crossover patterning is lost in Drosophila melanogaster mutants that lack the Bloom syndrome helicase. | Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction.
Hatkevich T, Kohl KP, McMahan S, Hartmann MA, Williams AM, Sekelsky J., Free PMC Article | 07/21/2018 |
| Blm helicase function plays a role in homologous recombination. Blm is not required for suppression of recombination between diverged sequences. | The Role of Blm Helicase in Homologous Recombination, Gene Conversion Tract Length, and Recombination Between Diverged Sequences in Drosophilamelanogaster.
Ertl HA, Russo DP, Srivastava N, Brooks JT, Dao TN, LaRocque JR., Free PMC Article | 03/31/2018 |
| Dme-miR-314-3p modulation in Cr(VI) exposed Drosophila affects DNA damage repair by targeting mus309 | Dme-miR-314-3p modulation in Cr(VI) exposed Drosophila affects DNA damage repair by targeting mus309.
Chandra S, Khatoon R, Pandey A, Saini S, Vimal D, Singh P, Chowdhuri DK. | 10/1/2016 |
| Drosophila BLM suppresses error-prone alternative end-joining repair of DNA double-strand breaks that can result in genome instability and tumor formation during aging. | Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Garcia AM, Salomon RN, Witsell A, Liepkalns J, Calder RB, Lee M, Lundell M, Vijg J, McVey M., Free PMC Article | 08/18/2012 |
| these studies of synthetic lethality provide insights into the multiple functions of DmBLM and how various endonucleases may function when DmBLM is absent | Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.
Andersen SL, Kuo HK, Savukoski D, Brodsky MH, Sekelsky J., Free PMC Article | 02/11/2012 |
| Data show that excision screens in mus309 mutant flies that lack DmBlm increases the percentage and overall size of flanking deletions recovered after excision of either P or Minos elements. | Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila.
Witsell A, Kane DP, Rubin S, McVey M., Free PMC Article | 04/19/2010 |
| The suppression of homeologous single strand annealing depends on the Bloom helicase (Blm), encoded by the Drosophila gene mus309. | Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences.
Kappeler M, Kranz E, Woolcock K, Georgiev O, Schaffner W., Free PMC Article | 01/21/2010 |
| mutations in mus81 and mms4 are synthetically lethal with null mutations in mus309 | Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.
Trowbridge K, McKim K, Brill SJ, Sekelsky J., Free PMC Article | 01/21/2010 |
| Mutations that delete the N terminus of DmBlm, but not the helicase domain, have DSB repair defects as severe as those caused by null mutations. | Multiple functions of Drosophila BLM helicase in maintenance of genome stability.
McVey M, Andersen SL, Broze Y, Sekelsky J., Free PMC Article | 01/21/2010 |
| Blm mutants are defective for homologous repair but show a compensating increase in single-strand annealing. | Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.
Johnson-Schlitz D, Engels WR., Free PMC Article | 01/21/2010 |
| model in which DmBlm acts downstream of strand invasion to unwind a D-loop intermediate to free the newly synthesized strand | Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.
McVey M, Larocque JR, Adams MD, Sekelsky JJ., Free PMC Article | 01/21/2010 |
| DmBLM combines DNA strand displacement with DNA strand annealing to catalyze the displacement of one DNA strand while annealing a second complementary DNA strand. | DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase.
Weinert BT, Rio DC., Free PMC Article | 01/21/2010 |
| Coding sequence of Ku70 gene is wild-type in two mus309 mutant lines. | The Drosophila melanogaster Ku70 coding sequence is wild-type in mus309 mutants.
Nicholas HR, Brookfield JF. | 01/21/2010 |
| results suggest a model in which BLM maintains genomic stability by promoting efficient repair DNA synthesis and thereby prevents double-strand break repair by less precise pathways | Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.
Adams MD, McVey M, Sekelsky JJ. | 01/21/2010 |
| Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration | Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration.
Plank JL, Wu J, Hsieh TS., Free PMC Article | 01/21/2010 |