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    MAPT microtubule associated protein tau [ Homo sapiens (human) ]

    Gene ID: 4137, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: a pilot study.

    Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: a pilot study.
    Sattarov R, Havers M, Orbjörn C, Stomrud E, Janelidze S, Laurell T, Mattsson-Carlgren N., Free PMC Article

    10/31/2024
    Cellular and pathological functions of tau.

    Cellular and pathological functions of tau.
    Parra Bravo C, Naguib SA, Gan L.

    10/31/2024
    Decreased extrasynaptic delta-GABAA receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.

    Decreased extrasynaptic δ-GABA(A) receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.
    Zhang W, Liu T, Li J, Singh J, Chan A, Islam A, Petrache A, Peng Y, Harvey K, Ali AB.

    10/18/2024
    Presenilin deficiency enhances tau phosphorylation and its secretion.

    Presenilin deficiency enhances tau phosphorylation and its secretion.
    Sun Y, Islam S, Gao Y, Nakamura T, Tomita T, Michikawa M, Zou K.

    10/16/2024
    Intracellular tau fragment droplets serve as seeds for tau fibrils.

    Intracellular tau fragment droplets serve as seeds for tau fibrils.
    Soeda Y, Yoshimura H, Bannai H, Koike R, Shiiba I, Takashima A.

    10/10/2024
    Synergistic Effect between the APOE epsilon4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease.

    Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease.
    Toral-Rios D, Pichardo-Rojas P, Ruiz-Sánchez E, Rosas-Carrasco Ó, Carvajal-García R, Gálvez-Coutiño DC, Martínez-Rodríguez NL, Rubio-Chávez AD, Alcántara-Flores M, López-Ramírez A, Martínez-Rosas AR, Ruiz-Chow ÁA, Alonso-Vanegas M, Campos-Peña V., Free PMC Article

    10/3/2024
    CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.

    CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.
    Nho K, Risacher SL, Apostolova LG, Bice PJ, Brosch JR, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR Jr, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Ertekin-Taner N, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), Australian Imaging, Biomarker & Lifestyle Study (AIBL), Saykin AJ., Free PMC Article

    09/29/2024
    Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis.

    Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis.
    Emeršič A, Karikari TK, Kac PR, Gonzalez-Ortiz F, Dulewicz M, Ashton NJ, Brecl Jakob G, Horvat Ledinek A, Hanrieder J, Zetterberg H, Rot U, Čučnik S, Blennow K.

    09/19/2024
    Interplay between glypican-1, amyloid-beta and tau phosphorylation in human neural stem cells.

    Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells.
    Cheng F, Fransson LÅ, Mani K.

    09/9/2024
    BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.

    BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.
    Thomson D, Rosenich E, Maruff P, Lim YY, Alzheimer’s Disease Neuroimaging Initiative., Free PMC Article

    08/31/2024
    Diverging Relationships among Amyloid, Tau, and Brain Atrophy in Early-Onset and Late-Onset Alzheimer's Disease.

    Diverging Relationships among Amyloid, Tau, and Brain Atrophy in Early-Onset and Late-Onset Alzheimer's Disease.
    Na HK, Shin JH, Kim SW, Seo S, Kim WR, Kang JM, Lee SY, Cho J, Byun J, Okamura N, Seong JK, Noh Y., Free PMC Article

    08/28/2024
    MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability.

    MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability.
    Bhopatkar AA, Bhatt N, Haque MA, Xavier R, Fung L, Jerez C, Kayed R., Free PMC Article

    08/21/2024
    Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.

    Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.
    Dando O, McGeachan R, McQueen J, Baxter P, Rockley N, McAlister H, Prasad A, He X, King D, Rose J, Jones PB, Tulloch J, Chandran S, Smith C, Hardingham G, Spires-Jones TL.

    08/21/2024
    MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy.

    MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy.
    Ressler HW, Humphrey J, Vialle RA, Babrowicz B, Kandoi S, Raj T, Dickson DW, Ertekin-Taner N, Crary JF, Farrell K., Free PMC Article

    08/19/2024
    G-protein coupled estrogen receptor 1, amyloid-beta, and tau tangles in older adults.

    G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults.
    Oveisgharan S, Yu L, de Paiva Lopes K, Petyuk VA, Tasaki S, Vialle R, Menon V, Wang Y, De Jager PL, Schneider JA, Bennett DA., Free PMC Article

    08/8/2024
    CryoET of beta-amyloid and tau within postmortem Alzheimer's disease brain.

    CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain.
    Gilbert MAG, Fatima N, Jenkins J, O'Sullivan TJ, Schertel A, Halfon Y, Wilkinson M, Morrema THJ, Geibel M, Read RJ, Ranson NA, Radford SE, Hoozemans JJM, Frank RAW., Free PMC Article

    07/26/2024
    Cysteine in the R3 Tau Peptide Modulates Hemin Binding and Reactivity.

    Cysteine in the R3 Tau Peptide Modulates Hemin Binding and Reactivity.
    Bacchella C, Guerriere TB, Monzani E, Dell'Acqua S.

    07/25/2024
    Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.

    Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.
    Qi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M., Free PMC Article

    07/19/2024
    Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease.

    Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease.
    Hoglund Z, Ruiz-Uribe N, Del Sastre E, Woost B, Bader E, Bailey J, Hyman BT, Zwang T, Bennett RE., Free PMC Article

    07/16/2024
    CHORDC1, the novel interacting partner of tau protein.

    CHORDC1, the novel interacting partner of tau protein.
    Pichlerová K, Šinský J, Kotásek M, Majerová P, Hanes J.

    07/11/2024
    Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease.

    Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease.
    Martinez-Horta S, Perez-Perez J, Perez-Gonzalez R, Sampedro F, Horta-Barba A, Campolongo A, Rivas-Asensio E, Puig-Davi A, Pagonabarraga J, Kulisevsky J., Free PMC Article

    07/3/2024
    Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.

    Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
    Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C., Free PMC Article

    06/26/2024
    Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study.

    Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study.
    Kochen NN, Seaney D, Vasandani V, Murray M, Braun AR, Sachs JN.,

    06/14/2024
    Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau.

    Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau.
    de Veij Mestdagh CF, Witte ME, Scheper W, Smit AB, Henning RH, van Kesteren RE., Free PMC Article

    06/12/2024
    Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway.

    Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway.
    Yakout DW, Shroff A, Wei W, Thaker V, Allen ZD, Sajish M, Nazarko TY, Mabb AM., Free PMC Article

    06/5/2024
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