| MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1. | MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1.
Shen S, Liu R, Huang J, Sun Y, Tan Q, Luo Q, Liu R., Free PMC Article | 10/31/2024 |
| Deregulated 14-3-3zeta and methionine adenosyltransferase alpha1 interplay promotes liver cancer tumorigenesis in mice and humans. | Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans.
Lu L, Zhang J, Fan W, Li Y, Wang J, Li TWH, Barbier-Torres L, Mato JM, Liu T, Seki E, Matsuda M, Tomasi ML, Bhowmick NA, Yang H, Lu SC., Free PMC Article | 08/28/2024 |
| Hepatic prohibitin 1 and methionine adenosyltransferase alpha1 defend against primary and secondary liver cancer metastasis. | Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis.
Fan W, Cao D, Yang B, Wang J, Li X, Kitka D, Li TWH, You S, Shiao S, Gangi A, Posadas E, Di Vizio D, Tomasi ML, Seki E, Mato JM, Yang H, Lu SC., | 02/22/2024 |
| Depletion of mitochondrial methionine adenosyltransferase alpha1 triggers mitochondrial dysfunction in alcohol-associated liver disease. | Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.
Barbier-Torres L, Murray B, Yang JW, Wang J, Matsuda M, Robinson A, Binek A, Fan W, Fernández-Ramos D, Lopitz-Otsoa F, Luque-Urbano M, Millet O, Mavila N, Peng H, Ramani K, Gottlieb R, Sun Z, Liangpunsakul S, Seki E, Van Eyk JE, Mato JM, Lu SC., Free PMC Article | 02/26/2022 |
| Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis. | Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis.
Chen PM, Tsai CH, Huang CC, Hwang HH, Li JR, Liu CC, Ko HA, Chiang EI., Free PMC Article | 02/5/2022 |
| Methionine adenosyltransferase I/III deficiency: Long-term follow-up and treatment of 3 adult siblings. | Methionine adenosyltransferase I/III deficiency: Long-term follow-up and treatment of 3 adult siblings.
Bannick A, Chase S, Miner A, Seeterlin M, Conway RL. | 06/5/2021 |
| Reciprocal Regulation Between Forkhead Box M1/NF-kappaB and Methionine Adenosyltransferase 1A Drives Liver Cancer. | Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer.
Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC., Free PMC Article | 05/8/2021 |
| Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. | Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene.
Panmanee J, Antonyuk SV, Hasnain SS., Free PMC Article | 01/23/2021 |
| Three newborns were identified with MAT I/III deficiency by newborn screening were found to carry MAT1A gene variants including two missense variants [c.776C>T (p.Ala259Val) and c.791G>A (p.Arg264His)] and a synonymous variant [c.360C>T (p.Cys120Cys)] | [Newborn screening and variant analysis for methionine adenosyltransferase I/III deficiency].
Lin C, Zheng Q, Jiang M, Lin Y. | 06/27/2020 |
| Overexpression of MAT1A in 5637 bladder cancer cells increased tolerance to gemcitabine and stalled cell proliferation rates, suggesting MAT1A upregulation as a potential mechanism by which bladder cancer cells persist in a quiescent state to evade chemotherapy. | Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice.
Martin KA, Hum NR, Sebastian A, He W, Siddiqui S, Ghosh PM, Pan CX, de Vere White R, Loots GG., Free PMC Article | 02/22/2020 |
| The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch. | A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Wang R, Jin Y, Yao XH, Fan W, Zhang J, Cao Y, Li J. | 04/27/2019 |
| Increased MAT1A expression is associated with recurrence in hepatocellular carcinoma. | Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.
An J, Na SK, Shim JH, Park YS, Jun MJ, Lee JH, Song GW, Lee HC, Yu E. | 06/30/2018 |
| interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis | Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡).
Yang H, Liu T, Wang J, Li TW, Fan W, Peng H, Krishnan A, Gores GJ, Mato JM, Lu SC., Free PMC Article | 07/22/2017 |
| Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR of CD44 was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44. | Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy.
Mumbrekar KD, Bola Sadashiva SR, Kabekkodu SP, Fernandes DJ, Vadhiraja BM, Suga T, Shoji Y, Nakayama F, Imai T, Satyamoorthy K. | 07/15/2017 |
| A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively. | [Analysis of MAT1A gene mutations in a child affected with simple hypermethioninemia].
Sun Y, Ma D, Wang Y, Yang B, Jiang T. | 07/1/2017 |
| S-adenosyl-L-methionine diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes. | S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.
Lozano-Sepulveda SA, Bautista-Osorio E, Merino-Mascorro JA, Varela-Rey M, Muñoz-Espinosa LE, Cordero-Perez P, Martinez-Chantar ML, Rivas-Estilla AM., Free PMC Article | 01/28/2017 |
| 5-Aza-CdR showed no effects on MAT2A methylation. | 5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production.
Liu WJ, Ren JG, Li T, Yu GZ, Zhang J, Li CS, Liu ZS, Liu QY. | 01/24/2015 |
| The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations. | Spectrum of mutations associated with methionine adenosyltransferase I/III deficiency among individuals identified during newborn screening in Japan.
Nagao M, Tanaka T, Furujo M. | 06/21/2014 |
| Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B. | Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
Shafqat N, Muniz JR, Pilka ES, Papagrigoriou E, von Delft F, Oppermann U, Yue WW., Free PMC Article | 06/29/2013 |
| Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review) | Methionine adenosyltransferase I/III deficiency: neurological manifestations and relevance of S-adenosylmethionine.
Furujo M, Kinoshita M, Nagao M, Kubo T. | 03/30/2013 |
| upregulation of miR-664, miR-485-3p, and miR-495 contributes to lower MAT1A expression in HCC, and enhanced tumorigenesis may provide potential targets for HCC therapy. | MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
Yang H, Cho ME, Li TW, Peng H, Ko KS, Mato JM, Lu SC., Free PMC Article | 03/16/2013 |
| Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. | Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.
Ji Y, Nordgren KK, Chai Y, Hebbring SJ, Jenkins GD, Abo RP, Peng Y, Pelleymounter LL, Moon I, Eckloff BW, Chai X, Zhang J, Fridley BL, Yee VC, Wieben ED, Weinshilboum RM., Free PMC Article | 02/16/2013 |
| we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma. | Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
Frau M, Tomasi ML, Simile MM, Demartis MI, Salis F, Latte G, Calvisi DF, Seddaiu MA, Daino L, Feo CF, Brozzetti S, Solinas G, Yamashita S, Ushijima T, Feo F, Pascale RM. | 10/20/2012 |
| Human Dead-box protein 3 (DDX3X), a RNA helicase regulating RNA splicing, export, transcription and translation was down-regulated upon MAT1A expression. | Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.
Schröder PC, Fernández-Irigoyen J, Bigaud E, Serna A, Renández-Alcoceba R, Lu SC, Mato JM, Prieto J, Corrales FJ., Free PMC Article | 10/20/2012 |
| genetic variant MAT1A 3U1510 displayed a significant interaction with dietary n-3:n-6 polyunsaturated fatty acids ratio in determining plasma homocysteine | MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations.
Huang T, Tucker K, Lee Y, Crott J, Parnell L, Shen J, Smith C, Ordovas J, Li D, Lai C., Free PMC Article | 07/28/2012 |