| Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. | Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Shohayeb B, Mitchell N, Millard SS, Quinn LM, Ng DCH. | 10/24/2020 |
| The data indicate that Aur-A depletion can elicit chromosome damage in Drosophila. | A new role for Drosophila Aurora-A in maintaining chromosome integrity.
Merigliano C, Mascolo E, Cesta A, Saggio I, Vernì F. | 08/10/2019 |
| AURKA directly regulates mitochondrial functions and that AURKA over-expression promotes metabolic reprogramming by increasing mitochondrial interconnectivity. | Aurora kinase A localises to mitochondria to control organelle dynamics and energy production.
Bertolin G, Bulteau AL, Alves-Guerra MC, Burel A, Lavault MT, Gavard O, Le Bras S, Gagné JP, Poirier GG, Le Borgne R, Prigent C, Tramier M., Free PMC Article | 02/16/2019 |
| WDR62 controls brain growth through lineage-specific interactions with master mitotic signaling kinase, aurora A kinase. | Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.
Lim NR, Shohayeb B, Zaytseva O, Mitchell N, Millard SS, Ng DCH, Quinn LM., Free PMC Article | 05/5/2018 |
| equatorial stimulation is mediated primarily by the delivery of factors to the cortex by noncentrosomal microtubules, as well as a midzone-derived phosphorylation gradient that is amplified by the concerted activities of mABK and a soluble pool of AAK. | Aurora A Kinase Amplifies a Midzone Phosphorylation Gradient to Promote High-Fidelity Cytokinesis.
Ye AA, Torabi J, Maresca TJ., Free PMC Article | 09/30/2017 |
| Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation. | Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.
Caous R, Pascal A, Romé P, Richard-Parpaillon L, Karess R, Giet R., Free PMC Article | 05/14/2016 |
| Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments. | Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.
Ye AA, Deretic J, Hoel CM, Hinman AW, Cimini D, Welburn JP, Maresca TJ., Free PMC Article | 04/23/2016 |
| AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types. | Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation.
Carvalho CA, Moreira S, Ventura G, Sunkel CE, Morais-de-Sá E. | 10/3/2015 |
| Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization. | Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.
Bell GP, Fletcher GC, Brain R, Thompson BJ., Free PMC Article | 10/3/2015 |
| Drosophila melanogaster aurora A phosphorylates the dynactin subunit p150(glued) on sites required for its association with the mitotic spindle. | Aurora A contributes to p150(glued) phosphorylation and function during mitosis.
Romé P, Montembault E, Franck N, Pascal A, Glover DM, Giet R., Free PMC Article | 07/5/2010 |
| Study identified a previously unrecognized evolutionarily conserved Pins domain (Pins(LINKER)) that requires Aurora-A phosphorylation to recruit Dlg and promote partial spindle orientation. | Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells.
Johnston CA, Hirono K, Prehoda KE, Doe CQ., Free PMC Article | 01/21/2010 |
| Study shows that a phosphorylation cascade triggered by the activation of Aurora-A is responsible for the asymmetric localization of Numb in mitosis. | Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
Wirtz-Peitz F, Nishimura T, Knoblich JA., Free PMC Article | 01/21/2010 |
| identification of Bora, a conserved protein required for activation of Aurora-A at the onset of mitosis; model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A | Mitotic activation of the kinase Aurora-A requires its binding partner Bora.
Hutterer A, Berdnik D, Wirtz-Peitz F, Zigman M, Schleiffer A, Knoblich JA. | 01/21/2010 |
| Study concludes that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal. | Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
Lee CY, Andersen RO, Cabernard C, Manning L, Tran KD, Lanskey MJ, Bashirullah A, Doe CQ., Free PMC Article | 01/21/2010 |
| Study shows that Aurora-A acts as a tumor suppressor by suppressing neuroblast self-renewal and promoting neuronal differentiation. | Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts.
Wang H, Somers GW, Bashirullah A, Heberlein U, Yu F, Chia W., Free PMC Article | 01/21/2010 |
| Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. | Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
Berdnik D, Knoblich JA. | 01/21/2010 |
| One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 microtubule-associated protein may be recruited, and thus modulate the behavior of astral microtubules. | Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.
Giet R, McLean D, Descamps S, Lee MJ, Raff JW, Prigent C, Glover DM., Free PMC Article | 01/21/2010 |
| Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein. | Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.
Stenoien DL, Sen S, Mancini MA, Brinkley BR. | 01/21/2010 |
| Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells | Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells.
Marumoto T, Honda S, Hara T, Nitta M, Hirota T, Kohmura E, Saya H. | 01/21/2010 |
| Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin to the centrosome and to organize microtubule-nucleating sites via interaction with CNN. | Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells.
Terada Y, Uetake Y, Kuriyama R., Free PMC Article | 01/21/2010 |