| Distinct Roles for COMPASS Core Subunits Set1, Trx, and Trr in the Epigenetic Regulation of Drosophila Heart Development. | Distinct Roles for COMPASS Core Subunits Set1, Trx, and Trr in the Epigenetic Regulation of Drosophila Heart Development.
Zhu JY, Lee H, Huang X, van de Leemput J, Han Z., Free PMC Article | 01/12/2024 |
| Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming. | Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.
Kuroda MI, Kang H, De S, Kassis JA., Free PMC Article | 06/5/2021 |
| Trx, Ash1, and CBP proteins are required for the correct chromosome segregation and that Ash1 and CBP mediate for Cid/CENP-A recruitment at centromeres through post-translational histone modifications. | A role of the Trx-G complex in Cid/CENP-A deposition at Drosophila melanogaster centromeres.
Piacentini L, Marchetti M, Bucciarelli E, Casale AM, Cappucci U, Bonifazi P, Renda F, Fanti L. | 04/18/2020 |
| Trx and Grx have both, common and specific protein Cys redox targets and that down regulation of either redoxin has markedly different metabolic outcomes. They reflect the delicate sensitivity of redox equilibrium to changes in any of the elements involved and the difficulty of forecasting metabolic responses to redox environmental changes. | Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches.
López-Grueso MJ, González-Ojeda R, Requejo-Aguilar R, McDonagh B, Fuentes-Almagro CA, Muntané J, Bárcena JA, Padilla CA., Free PMC Article | 04/6/2019 |
| Mrg15 is a subunit of the Ash1 complex, a stimulator of Ash1 enzymatic activity and a critical regulator of the TrxG protein function of Ash1 in Drosophila. | Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.
Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R, Zhu B., Free PMC Article | 10/6/2018 |
| we demonstrate that the evolutionary conserved Lim3 core promoter provides basic Lim3 expression, whereas structural changes in the Lim3 PRE of distal promoter provide stage-, and tissue-specific Lim3 expression. Therefore, we hypothesize that PcG/TrxG proteins, which are directly involved in Lim3 transcription regulation, participate in lifespan control. | Polycomb/Trithorax group-dependent regulation of the neuronal gene Lim3 involved in Drosophila lifespan control.
Rybina OY, Rozovsky YM, Veselkina ER, Pasyukova EG. | 07/14/2018 |
| Control of the gene activity by polycomb and trithorax group proteins in Drosophila | [Control of the gene activity by polycomb and trithorax group proteins in Drosophila].
Chetverina DA, Elizar’ev PV, Lomaev DV, Georgiev PG, Erokhin MM. | 02/17/2018 |
| Taken together, these data indicate that Atrophin is a major Trithorax-like cofactor that functions to moderate developmental gene transcription. | Atrophin controls developmental signaling pathways via interactions with Trithorax-like.
Yeung K, Boija A, Karlsson E, Holmqvist PH, Tsatskis Y, Nisoli I, Yap D, Lorzadeh A, Moksa M, Hirst M, Aparicio S, Fanto M, Stenberg P, Mannervik M, McNeill H., Free PMC Article | 01/13/2018 |
| Trithorax positively regulates gene expression in Drosophila and co-occupies PREs to antagonize Polycomb-dependent silencing. Trx-dependent H3K4 dimethylation (H3K4me2) marks Drosophila PREs and maintains the developmental expression pattern of nearby genes. | An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.
Rickels R, Hu D, Collings CK, Woodfin AR, Piunti A, Mohan M, Herz HM, Kvon E, Shilatifard A., Free PMC Article | 08/26/2017 |
| If ASH1 or TRX function is lost or reduced, heterochromatin can spread into these domains creating a sink that diverts heterochromatic proteins from other variegating locations, which then may express a suppressed phenotype. | Mutations in ash1 and trx enhance P-element-dependent silencing in Drosophila melanogaster.
McCracken A, Locke J. | 04/8/2017 |
| Trithorax has a role in regulating systemic signaling during Drosophila imaginal disc regeneration | Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration.
Skinner A, Khan SJ, Smith-Bolton RK., Free PMC Article | 02/20/2016 |
| Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonhead. | Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonhead.
Komori H, Xiao Q, Janssens DH, Dou Y, Lee CY., Free PMC Article | 06/27/2015 |
| From the Drosophila melanogaster vestigial (vg) Polycomb response element/Trithorax response element switches the status of the element. | A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element.
Herzog VA, Lempradl A, Trupke J, Okulski H, Altmutter C, Ruge F, Boidol B, Kubicek S, Schmauss G, Aumayr K, Ruf M, Pospisilik A, Dimond A, Senergin HB, Vargas ML, Simon JA, Ringrose L., Free PMC Article | 01/17/2015 |
| CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element | The CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element (PRE).
Basu A, Dasari V, Mishra RK, Khosla S., Free PMC Article | 01/17/2015 |
| mutations in PcG components and in TrxG members found in chromatin remodeling complexes enhance the gcm dominant phenotype, suggesting a balanced action of these chromatin modifiers regulate Gcm function | Polycomb controls gliogenesis by regulating the transient expression of the Gcm/Glide fate determinant.
Popkova A, Bernardoni R, Diebold C, Van de Bor V, Schuettengruber B, González I, Busturia A, Cavalli G, Giangrande A., Free PMC Article | 05/11/2013 |
| Data imply that Trx, Pc, and E(z) remain bound or rapidly rebind to nascent DNA in the absence of trimethylated histones during DNA replication in Drosophila embryos. | TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.
Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A., Free PMC Article | 11/17/2012 |
| dHCF possesses Enhancer of TrxG and PcG (ETP) properties. | Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators.
Rodriguez-Jato S, Busturia A, Herr W., Free PMC Article | 04/28/2012 |
| Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators | [Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators].
Shvarts IuB, Kahn TG, Pirrotta V. | 02/26/2011 |
| These findings establish a role for PRC2 and TRX in the modulation of organismal longevity and stress resistance and indicate that moderate perturbation of Polycomb silencing can increase longevity. | Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.
Siebold AP, Banerjee R, Tie F, Kiss DL, Moskowitz J, Harte PJ., Free PMC Article | 03/15/2010 |
| Hsp90 cooperates with Trx at chromatin for maintaining the active expression state of targets like the Hox genes. | Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression.
Tariq M, Nussbaumer U, Chen Y, Beisel C, Paro R., Free PMC Article | 01/21/2010 |
| results indicate that DNA binding proteins serve as platforms to assist PcG and trxG binding. Furthermore, several DNA sequence features discriminate between PcG- and TRX-N-bound regions | Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos.
Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, van Lohuizen M, Tanay A, Cavalli G., Free PMC Article | 01/21/2010 |
| Computational analysis ofmicroarray data, identified 25 clusters of genes potentially regulated by TRX; most of these clusters consist of genes that encode structural proteins involved in cuticle formation. | Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila.
Blanco E, Pignatelli M, Beltran S, Punset A, Pérez-Lluch S, Serras F, Guigó R, Corominas M., Free PMC Article | 01/21/2010 |
| Data demonstrate that the Drosophila homologs of mixed-lineage leukemia protein and host cell factor 1, called Trithorax and dHCF, are both cleaved by Drosophila taspase 1. | Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.
Capotosti F, Hsieh JJ, Herr W., Free PMC Article | 01/21/2010 |
| identified several members of the Polycomb and trithorax classes of genes required for the normal pattern of photoreceptor differentiation | A mosaic genetic screen reveals distinct roles for trithorax and polycomb group genes in Drosophila eye development.
Janody F, Lee JD, Jahren N, Hazelett DJ, Benlali A, Miura GI, Draskovic I, Treisman JE., Free PMC Article | 01/21/2010 |
| This suggests that TRITHORAX bound to certain regulatory chromosome regions interacts with the adjacent elements of the nuclear scaffold, i.e., links the regions of actively transcribed genes with the nuclear matrix. | [Trithorax protein, a global factor for maintenance of tissue specific gene activation in Drosophila melanogaster, is associated with the nuclear matrix].
Lebedeva LA, Tillib SV. | 01/21/2010 |