| A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila. | A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.
Wang C, Girton J, Johansen J, Johansen KM., Free PMC Article | 01/21/2012 |
| RNA helicase interacts with the well-characterized histone methyltransferase SU(VAR)3-9 via its N-terminus, which provides a potential mechanism for the targeting of H3K9 methylation to highly regulated genes. | The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.
Boeke J, Bag I, Ramaiah MJ, Vetter I, Kremmer E, Pal-Bhadra M, Bhadra U, Imhof A., Free PMC Article | 10/1/2011 |
| the SUUR protein is required for the SU(VAR)3-9 enzyme to bind to the salivary gland polytene chromosomes | The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster.
Koryakov DE, Walther M, Ebert A, Lein S, Zhimulev IF, Reuter G. | 09/3/2011 |
| Data show that animals with reduced heterochromatin, such as Stat92E transheterozygotes, Su(var)205 heterozygotes, or Su(var)3-9 transheterozygotes, were less viable than wild-type controls. | Unphosphorylated STAT and heterochromatin protect genome stability.
Yan SJ, Lim SJ, Shi S, Dutta P, Li WX., Free PMC Article | 03/12/2011 |
| The genetic interactions between dSETDB1 and Su(var)3-9 mutations emphasize the importance of maintaining the activities of these histone methyltransferases in balance for normal genome function. | Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.
Brower-Toland B, Riddle NC, Jiang H, Huisinga KL, Elgin SC., Free PMC Article | 01/21/2010 |
| results indicate that dSETDB1 and SU(VAR)3-9 act together with distinct roles during oogenesis, with dsetdb1 being of particular importance due to its germline stem cell-specific function and more severe mutant phenotype | dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster.
Yoon J, Lee KS, Park JS, Yu K, Paik SG, Kang YK., Free PMC Article | 01/21/2010 |
| describe how, in double mutants for Su(var)3-9 and Suppressor of Under-Replication genes encoding two structural proteins of heterochromatin, new banded heterochromatic segments appear in all polytene chromosomes | High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants.
Andreyeva EN, Kolesnikova TD, Demakova OV, Mendez-Lago M, Pokholkova GV, Belyaeva ES, Rossi F, Dimitri P, Villasante A, Zhimulev IF., Free PMC Article | 01/21/2010 |
| Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9 | Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine.
Seeger K, Lein S, Reuter G, Berger S. | 01/21/2010 |
| Su(var)3-7 expression is sufficient to induce Su(var)3-9-dependent ectopic heterochromatinisation; there may be a functional link between Su(var)3-7 and the histone-methyltransferase Su(var)3-9 | Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation.
Delattre M, Spierer A, Jaquet Y, Spierer P. | 01/21/2010 |
| Pericentric heterochromatin is heterogeneous in its requirement for SU(VAR)3-9 with respect to the establishment of the condensed state, time of replication, and DNA polytenization. | The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster.
Demakova OV, Pokholkova GV, Kolesnikova TD, Demakov SA, Andreyeva EN, Belyaeva ES, Zhimulev IF., Free PMC Article | 01/21/2010 |
| role in chromatin organization at the histone gene cluster and in suppression of position-effect variegation | A role for the Drosophila SU(VAR)3-9 protein in chromatin organization at the histone gene cluster and in suppression of position-effect variegation.
Ner SS, Harrington MJ, Grigliatti TA., Free PMC Article | 01/21/2010 |
| central role of the SU(VAR)3-9 protein in heterochromatic gene silencing | SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing.
Schotta G, Ebert A, Reuter G. | 01/21/2010 |
| A mutation in SuUR gene results in a decrease in the amount of SU(VAR)3-9 binding sites in autosomes.the SU(VAR)3-9 protein was found in pericentric heterochromatin and at 223 sites on euchromatic arms. | The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster.
Koryakov DE, Reuter G, Dimitri P, Zhimulev IF. | 01/21/2010 |
| These data indicate a central role for the SU(VAR)3-9 HMTase in heterochromatin-induced gene silencing in Drosophila.SU(VAR)3-9 is the major heterochromatin-specific HMTase in Drosophila. | Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G., Free PMC Article | 01/21/2010 |
| The full-length SU(VAR)3-9 enzyme transfers two methyl groups to lysine 9 within a histone 3 tail peptide in a nonprocessive manner, requiring the N-terminus for homodimerization and for full activity in vitro. | The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity.
Eskeland R, Czermin B, Boeke J, Bonaldi T, Regula JT, Imhof A. | 01/21/2010 |
| SU(VAR)3-9, facilitates HP1 binding to chromatin methylated at lysine 9 within the H3 N terminus (H3K9). | HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors.
Eskeland R, Eberharter A, Imhof A., Free PMC Article | 01/21/2010 |
| Developmental and chromosomal defects induced by DNA hypermethylation could be rescued by mutant alleles of the histone H3-K9 methyltransferase gene Su(var)3-9 | DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications.
Weissmann F, Muyrers-Chen I, Musch T, Stach D, Wiessler M, Paro R, Lyko F., Free PMC Article | 01/21/2010 |
| displays extensive H3-K9 di- and trimethylation within but also outside pericentric heterochromatin | Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila.
Ebert A, Schotta G, Lein S, Kubicek S, Krauss V, Jenuwein T, Reuter G., Free PMC Article | 01/21/2010 |