| Rac1 and Akt Exhibit Distinct Roles in Mediating Abeta-Induced Memory Damage and Learning Impairment. | Rac1 and Akt Exhibit Distinct Roles in Mediating Aβ-Induced Memory Damage and Learning Impairment.
Cheng KC, Chen YH, Wu CL, Lee WP, Cheung CHA, Chiang HC. | 02/5/2022 |
| Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure. | Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure.
Moore NS, Mans RA, McCauley MK, Allgood CS, Barksdale KA., Free PMC Article | 10/23/2021 |
| Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration. | Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.
Esteban-Collado J, Corominas M, Serras F. | 09/25/2021 |
| Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila. | Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila.
Wang Q, Fan H, Li F, Skeeters SS, Krishnamurthy VV, Song Y, Zhang K., Free PMC Article | 02/27/2021 |
| Akt is involved in the aging process and Abeta toxicity, and manipulating Akt can restore both neuronal functions and improve behavioral activity during the processes of aging and Alzheimer's disease pathogenesis. | Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity.
Chen YR, Li YH, Hsieh TC, Wang CM, Cheng KC, Wang L, Lin TY, Cheung CHA, Wu CL, Chiang H., Free PMC Article | 07/11/2020 |
| The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. | The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth.
Borreguero-Muñoz N, Fletcher GC, Aguilar-Aragon M, Elbediwy A, Vincent-Mistiaen ZI, Thompson BJ., Free PMC Article | 02/29/2020 |
| Flies lacking fat body fs(1)h exhibit short lifespan, increased expression of immune target genes, an inability to metabolize triglyceride, and low basal AKT activity, mostly resulting from systemic defects in insulin signalling. | fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila.
Sharrock J, Estacio-Gomez A, Jacobson J, Kierdorf K, Southall TD, Dionne MS., Free PMC Article | 01/18/2020 |
| Phosphorylation of Akt on the Pdk1 site, Thr342, is significantly reduced by Toll signaling, and expression of mutant Akt(T342D) rescues cell and animal growth, nutrient storage, and viability in animals with active Toll signaling. | Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation.
Roth SW, Bitterman MD, Birnbaum MJ, Bland ML., Free PMC Article | 06/22/2019 |
| Our findings demonstrate a non-autonomous activation of a ROS sensing mechanism by Ask1 and Akt1 to replace the missing tissue after damage. Collectively, these results provide the basis for understanding the molecular mechanism of communication between dying and living cells that triggers regeneration. | Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila.
Santabárbara-Ruiz P, Esteban-Collado J, Pérez L, Viola G, Abril JF, Milán M, Corominas M, Serras F., Free PMC Article | 03/16/2019 |
| The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants. | A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila.
Fischer P, Preiss A, Nagel AC., Free PMC Article | 08/12/2017 |
| Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism. | Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.
Lin CH, Lin HI, Chen ML, Lai TT, Cao LP, Farrer MJ, Wu RM, Chien CT. | 07/29/2017 |
| subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila. | Enhanced survival of Drosophila Akt1 hypomorphs during amino-acid starvation requires foxo.
Slade JD, Staveley BE. | 10/29/2016 |
| The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones | Compensatory growth in novel Drosophila Akt1 mutants.
Slade JD, Staveley BE., Free PMC Article | 01/16/2016 |
| these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation | Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase.
Das R, Sebo Z, Pence L, Dobens LL., Free PMC Article | 07/4/2015 |
| AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels. | Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.
Nandi N, Tyra LK, Stenesen D, Krämer H., Free PMC Article | 01/10/2015 |
| Akt1 governs two critical elements of synapse development, neurotransmitter receptor localization, and postsynaptic membrane elaboration | Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction.
Lee HG, Zhao N, Campion BK, Nguyen MM, Selleck SB., Free PMC Article | 04/12/2014 |
| Tsc2 mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 mutants, leading to the hypothesis that Tsc2 and Akt might work via the same genetic pathway to regulate synapse growth. | Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway.
Natarajan R, Trivedi-Vyas D, Wairkar YP. | 11/2/2013 |
| Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity. | Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.
Ye X, Deng Y, Lai ZC. | 10/20/2012 |
| Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. | Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN., Free PMC Article | 09/29/2012 |
| Overexpression of Akt enhanced Sindbis virus replication. | Role for the phosphatidylinositol 3-kinase-Akt-TOR pathway during sindbis virus replication in arthropods.
Patel RK, Hardy RW., Free PMC Article | 06/16/2012 |
| Perturbation of the Akt/Gsk3-beta signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. | Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.
van Eyk CL, O'Keefe LV, Lawlor KT, Samaraweera SE, McLeod CJ, Price GR, Venter DJ, Richards RI., Free PMC Article | 10/15/2011 |
| dAkt activation under wild-type conditions is defined by feedback inhibition that depends on TOR Complex 1 | Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.
Kockel L, Kerr KS, Melnick M, Brückner K, Hebrok M, Perrimon N., Free PMC Article | 10/4/2010 |
| Studies indicate that knockdown of dGirdin in the Drosophila wing imaginal disc cells resulted in reduction of cell size and this was enhanced by half reduction of the Akt gene dose. | dGirdin a new player of Akt /PKB signaling in Drosophila Melanogaster.
Yamaguchi M, Suyari O, Nagai R, Takahashi M. | 09/20/2010 |
| shows that phosphorylation of the Tsc1/2 complex by Akt is not required for Akt to activate TORC1 and to promote tissue growth in Drosophila | Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth.
Schleich S, Teleman AA., Free PMC Article | 01/21/2010 |
| The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila | The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.
Vereshchagina N, Ramel MC, Bitoun E, Wilson C. | 01/21/2010 |