| CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract. | CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract.
Cui F, Sun Z, Zhang X, Liu C. | 04/23/2024 |
| CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract. | CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.
Ma Y, Liu Y, Shu B, Yang J, Lv L, Zhou L, Wang L, Shi Z., Free PMC Article | 01/21/2023 |
| Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease. | Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease.
He Z, Bin Y, Chen G, Li Q, Fan W, Ma Y, Yi J, Luo X, Tan Z, Li J., Free PMC Article | 11/26/2022 |
| Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population. | Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population.
Sun Y, Lv Y, Ren HW, Wang GY, Xuan LN, Luo YY, Luan ZL. | 05/28/2022 |
| Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching. | Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.
Shendy NAM, Raghu D, Roy S, Perry CH, Safi A, Branco MR, Homayouni R, Abell AN., Free PMC Article | 06/26/2021 |
| A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. | A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.
Gupta A, Ökesli-Armlovich A, Morgens D, Bassik MC, Khosla C., Free PMC Article | 10/24/2020 |
| These mutations increase the binding of the RHOA, MAP3K4 and FRAT1 proteins and generally decrease the binding of RAC1. Thus, pathologies in MAP3K1 disrupt the balance between the pro-kinase activities of the RHOA and MAP3K4 binding partners and the inhibitory activity of RAC1. | Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein.
Chamberlin A, Huether R, Machado AZ, Groden M, Liu HM, Upadhyay K, O V, Gomes NL, Lerario AM, Nishi MY, Costa EMF, Mendonca B, Domenice S, Velasco J, Loke J, Ostrer H. | 02/8/2020 |
| MAP3K4 was up-regulated and its expression was inversely correlated with collagen expression in the osteoblasts from older donors. | Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis.
Zhang X, Zhao G, Zhang Y, Wang J, Wang Y, Cheng L, Sun M, Rui Y. | 06/1/2019 |
| IL-21 expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma | The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma.
Fredholm S, Litvinov IV, Mongan NP, Schiele S, Willerslev-Olsen A, Petersen DL, Krejsgaard T, Sibbesen N, Nastasi C, Bonefeld CM, Persson JL, Straten PT, Andersen MH, Koralov SB, Wasik MM, Geisler C, Sasseville D, Woetmann A, Ødum N. | 08/20/2016 |
| Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. | Integrative identification of Epstein-Barr virus-associated mutations and epigenetic alterations in gastric cancer.
Liang Q, Yao X, Tang S, Zhang J, Yau TO, Li X, Tang CM, Kang W, Lung RW, Li JW, Chan TF, Xing R, Lu Y, Lo KW, Wong N, To KF, Yu C, Chan FK, Sung JJ, Yu J. | 02/7/2015 |
| Map3k4 haploinsufficiency is the cause of T-associated sex reversal. | Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.
Warr N, Siggers P, Carré GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Teboul L, Wells S, Sanderson J, Greenfield A., Free PMC Article | 01/17/2015 |
| MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells. | HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4).
Sollome JJ, Thavathiru E, Camenisch TD, Vaillancourt RR., Free PMC Article | 06/28/2014 |
| MAP3K4 is sufficiently mediate the TGFbeta-induced phosphorylation of p38 MAPK in MEFs and HaCaT cells. | The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.
Sapkota GP., Free PMC Article | 01/4/2014 |
| we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease. | Defective IL-1A expression in patients with Crohn's disease is related to attenuated MAP3K4 signaling.
van der Pouw Kraan CT, Baggen JM, van Bodegraven AA, Mulder CJ, Zwiers A, Geerts D, Kraal G, Horrevoets AJ, Bouma G. | 01/12/2013 |
| For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism. | Association study of 45 candidate genes in nicotine dependence in Han Chinese.
Wei J, Chu C, Wang Y, Yang Y, Wang Q, Li T, Zhang L, Ma X. | 06/2/2012 |
| The upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner. | MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation.
Sun BK, Kim JH, Nguyen HN, Oh S, Kim SY, Choi S, Choi HJ, Lee YJ, Song JJ., Free PMC Article | 05/14/2011 |
| CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 | Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.
Kedar VP, Darby MK, Williams JG, Blackshear PJ., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.
Grucza RA, Johnson EO, Krueger RF, Breslau N, Saccone NL, Chen LS, Derringer J, Agrawal A, Lynskey M, Bierut LJ., Free PMC Article | 09/15/2010 |
| Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. | Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.
Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC. | 01/21/2010 |
| MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway | MEKK4 is an effector of the embryonic TRAF4 for JNK activation.
Abell AN, Johnson GL. | 01/21/2010 |
| Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. | CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P. | 01/21/2010 |
| In this review, the role of MKK4 in cancer development appears complex, as some studies support a pro-oncogenic role for MKK4, while others suggest it may have tumor suppressor functions. | Role of mitogen-activated protein kinase kinase 4 in cancer.
Whitmarsh AJ, Davis RJ. | 01/21/2010 |