| Differential activation of rhodopsin triggers distinct endocytic trafficking and recycling in vivo via differential phosphorylation. | Differential activation of rhodopsin triggers distinct endocytic trafficking and recycling in vivo via differential phosphorylation.
Ferng D, Sun W, Shieh BH., Free PMC Article | 10/31/2024 |
| we report the identification of a retinoid-inducible gene in Drosophila, highroad, which is required for photoreceptors to clear folding-defective mutant Rhodopsin-1 proteins | highroad Is a Carboxypetidase Induced by Retinoids to Clear Mutant Rhodopsin-1 in Drosophila Retinitis Pigmentosa Models.
Huang HW, Brown B, Chung J, Domingos PM, Ryoo HD., Free PMC Article | 05/27/2019 |
| These data demonstrate that the V1 and V0 components of V-ATPase play key roles in post-Golgi trafficking of Rh1. | The V-ATPase V1 subunit A1 is required for rhodopsin anterograde trafficking in Drosophila.
Zhao H, Wang J, Wang T., Free PMC Article | 03/30/2019 |
| The Rh1(also known as NinaE))-trafficking defect in PIP4K-depleted cells could be suppressed by downregulating Rab5 function or by selectively reconstituting PIP4K in the PI3P-enriched early endosomal compartment of photoreceptors | Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis.
Kamalesh K, Trivedi D, Toscano S, Sharma S, Kolay S, Raghu P., Free PMC Article | 03/31/2018 |
| Organisms use multiple strategies to maximize visual capabilities in different light conditions. Many invertebrates show a daily cycle of shedding the photoreceptor's rhabdomeric membranes at dawn and rebuilding these during the following night. We show here that the Aedes aegypti mosquito possesses two distinct light-driven cellular signaling processes for modulating rhodopsin content during this cycle. | Light-Driven Processes Control Both Rhodopsin Maturation and Recycling in Mosquito Photoreceptors.
Metoxen AJ, Leming MT, Hu X, Whaley MA, O'Tousa JE., Free PMC Article | 07/15/2017 |
| Fmr1 protein associates with ninaE mRNA and represses its translation. | Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.
Wang X, Mu Y, Sun M, Han J. | 05/27/2017 |
| Data show that site-directed mutagenesis of conserved residues has only modest effects on Rhodopsin 1 absorption. | Analysis of Conserved Glutamate and Aspartate Residues in Drosophila Rhodopsin 1 and Their Influence on Spectral Tuning.
Zheng L, Farrell DM, Fulton RM, Bagg EE, Salcedo E, Manino M, Britt SG., Free PMC Article | 01/16/2016 |
| Data indicate that mutations in Golgi SNARE protein gos28 lead to defective rhodopsin (Rh1) trafficking. | The Gos28 SNARE protein mediates intra-Golgi transport of rhodopsin and is required for photoreceptor survival.
Rosenbaum EE, Vasiljevic E, Cleland SC, Flores C, Colley NJ., Free PMC Article | 02/14/2015 |
| Upon light stimulation, Crag is required for trafficking of Rh from the trans-Golgi network to rhabdomere membranes via a Rab11-dependent vesicular transport. | Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.
Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng WL, Li T, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ., Free PMC Article | 05/25/2013 |
| GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors | GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors.
Satoh T, Inagaki T, Liu Z, Watanabe R, Satoh AK. | 02/23/2013 |
| Our results indicate that fatp promotes photoreceptor survival by regulating Rh1 abundance | Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.
Dourlen P, Bertin B, Chatelain G, Robin M, Napoletano F, Roux MJ, Mollereau B., Free PMC Article | 01/5/2013 |
| Dominant rhodopsin (ninaE) mutants showed progressive age-dependent and light-independent loss of the deep pseudopupil. | Characterization of two dominant alleles of the major rhodopsin-encoding gene ninaE in Drosophila.
Mitra A, Chinchore Y, Kinser R, Dolph PJ., Free PMC Article | 04/28/2012 |
| These data show that the Drosophila metallophosphoesterase-dephosphorylated alpha-Man-II is required for the removal of the Rh1 oligosaccharide chain. | A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin.
Cao J, Li Y, Xia W, Reddig K, Hu W, Xie W, Li HS, Han J., Free PMC Article | 11/5/2011 |
| Data propose that Rh1 function in promoting RTW morphogenesis is not only needed to sustain apical membrane delivery but is also required for proper rhabdomeric membrane endocytosis and turnover. | Dynamin- and Rab5-dependent endocytosis is required to prevent Drosophila photoreceptor degeneration.
Pinal N, Pichaud F., Free PMC Article | 09/24/2011 |
| mutation of ninaE encoding Drosophila rhodopsin eliminates thermotactic discrimination in the comfortable temperature range; propose that rhodopsins represent a class of evolutionarily conserved GPCRs required for initiating thermosensory signaling | Function of rhodopsin in temperature discrimination in Drosophila.
Shen WL, Kwon Y, Adegbola AA, Luo J, Chess A, Montell C. | 04/2/2011 |
| Genetic inactivation of ter94 increased the levels of misfolded Rh1 in retina. | Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila.
Griciuc A, Aron L, Roux MJ, Klein R, Giangrande A, Ueffing M., Free PMC Article | 01/1/2011 |
| Findings demonstrate that light-induced translocation of Arr2 occurs through a noncanonical rhodopsin/Rac2 pathway, which is distinct from the classical phototransduction cascade. | Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2.
Elsaesser R, Kalra D, Li R, Montell C., Free PMC Article | 05/31/2010 |
| Data show tat mutant flies bearing certain ninaE alleles have dramatically reduced rhodopsin-1 protein levels. | Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation.
Kang MJ, Ryoo HD., Free PMC Article | 01/21/2010 |
| Data show that the double Rhodopsin 1 (ninaE) and Rhodopsin mutant was not entrained to red light. | Circadian entrainment to red light in Drosophila: requirement of Rhodopsin 1 and Rhodopsin 6.
Hanai S, Hamasaka Y, Ishida N. | 01/21/2010 |
| NinaE(pp100) represented the first rhodopsin mutation that stabilized rhodopsin-arrestin complex and led to elevated levels of G(q)alpha in the cytosol, which mediated a novel retinal degeneration pathway | Novel dominant rhodopsin mutation triggers two mechanisms of retinal degeneration and photoreceptor desensitization.
Iakhine R, Chorna-Ornan I, Zars T, Elia N, Cheng Y, Selinger Z, Minke B, Hyde DR., Free PMC Article | 01/21/2010 |
| expression of ceramidase facilitates the dissolution of incompletely formed and inappropriately located elements of rhabdomeric membranes in ninaE(I17) mutants lacking the G protein receptor Rh1 in R1-R6 photoreceptor cells | Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Acharya U, Mowen MB, Nagashima K, Acharya JK., Free PMC Article | 01/21/2010 |
| We present evidence that the Drosophila GBS regulatory element (Glass-binding site), derived from the Rh1 rhodopsin gene, is able to drive in vivo eye-specific expression of a Ccwhite+ transgene in the Mediterranean fruitfly Ceratitis capitata. | A new Minos vector for eye-specific expression of white+ marker in Ceratitis capitata and in distantly related dipteran species.
Salvemini M, Mauro U, Velaeti S, Polito C, Saccone G. | 01/21/2010 |