| Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster. | Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
Khanbabei A, Segura L, Petrossian C, Lemus A, Cano I, Frazier C, Halajyan A, Ca D, Loza-Coll M. | 12/22/2023 |
| We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP. Together, these data constitute a considerable step forward in understanding the role of JAK/STAT signaling in ASPs and similar structures in mammalian models | JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster.
Powers N, Srivastava A. | 05/16/2020 |
| Thus, CtBP stabilizes cell fates following damage by opposing the destabilizing effects of the JNK/AP-1 and JAK/STAT pathways. | CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs.
Worley MI, Alexander LA, Hariharan IK., Free PMC Article | 08/10/2019 |
| dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis. | JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling.
Recasens-Alvarez C, Ferreira A, Milán M., Free PMC Article | 11/17/2018 |
| Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK/STAT activation was suppressed by fusion-inducing JNK signaling. | Spatiotemporal regulation of cell fusion by JNK and JAK/STAT signaling during Drosophila wound healing.
Lee JH, Lee CW, Park SH, Choe KM. | 03/17/2018 |
| Data show that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation. | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.
Kucinski I, Dinan M, Kolahgar G, Piddini E., Free PMC Article | 11/18/2017 |
| Examination of the epistatic relationship between candidate genes and Stat92E reveals that Ptp61F and brm interact with Stat92E during both border cell specification and migration. | Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary.
Saadin A, Starz-Gaiano M., Free PMC Article | 11/18/2017 |
| The current study further solidified the role of STAT and Wg in regeneration, by identifying their contribution to abnormal regenerations induced by IR. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth | STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila.
Verghese S, Su TT., Free PMC Article | 11/11/2017 |
| Resistance to ionizing radiation-induced apoptosis requires STAT and Wg and is mediated by transcriptional repression of the pro-apoptotic gene reaper. | Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation.
Verghese S, Su TT., Free PMC Article | 07/8/2017 |
| critical in vivo regulator of glial responsiveness to axonal injury | PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury.
Doherty J, Sheehan AE, Bradshaw R, Fox AN, Lu TY, Freeman MR., Free PMC Article | 12/26/2015 |
| we applied motif discovery to search for candidate transcription factors that could bind these regions and identified AP-1 and Stat92E as key regulators. | Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling.
Davie K, Jacobs J, Atkins M, Potier D, Christiaens V, Halder G, Aerts S., Free PMC Article | 07/25/2015 |
| educed Wingless (Wg) signaling dominantly inhibits Stat92E activity in the hinge | JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc.
Ayala-Camargo A, Anderson AM, Amoyel M, Rodrigues AB, Flaherty MS, Bach EA., Free PMC Article | 12/14/2013 |
| stat92E activity is regulated along the proximodistal axis to pattern this axis and control the relative expansion of the pouch, hinge, and notum in developing Drosophila | Essential roles for stat92E in expanding and patterning the proximodistal axis of the Drosophila wing imaginal disc.
Hatini V, Kula-Eversole E, Nusinow D, Del Signore SJ., Free PMC Article | 07/13/2013 |
| Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. | Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells.
Sotillos S, Krahn M, Espinosa-Vázquez JM, Hombría JC. | 05/18/2013 |
| Jak-STAT signaling from the hub acts on both GSCs and CySC to regulate their development and differentiation, and that additional signaling from CySCs to the GSCs play a dominant role in controlling GSC maintenance during niche formation. | Jak-STAT regulation of cyst stem cell development in the Drosophila testis.
Sinden D, Badgett M, Fry J, Jones T, Palmen R, Sheng X, Simmons A, Matunis E, Wawersik M., Free PMC Article | 03/2/2013 |
| Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. | Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.
Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. | 02/2/2013 |
| modulating STAT activity levels regulates competitor status | Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis.
Rodrigues AB, Zoranovic T, Ayala-Camargo A, Grewal S, Reyes-Robles T, Krasny M, Wu DC, Johnston LA, Bach EA., Free PMC Article | 12/22/2012 |
| Studies identify miR-279 as a component of a feedback pathway that further dampens the response in cells with low levels of JAK/STAT activity. | miRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold.
Yoon WH, Meinhardt H, Montell DJ., Free PMC Article | 12/10/2011 |
| the JAK/STAT pathway is necessary and sufficient for optic lobe neuroepithelial growth. | Role of JAK/STAT signaling in neuroepithelial stem cell maintenance and proliferation in the Drosophila optic lobe.
Wang W, Li Y, Zhou L, Yue H, Luo H. | 09/24/2011 |
| Loss of Stat92E in the early embryo down-regulates early zygotic genes important for pattern formation. | STAT is an essential activator of the zygotic genome in the early Drosophila embryo.
Tsurumi A, Xia F, Li J, Larson K, LaFrance R, Li WX., Free PMC Article | 09/24/2011 |
| Data suggest that ISC self-renewal is cooperatively controlled by EGFR, Wg and JAK/STAT signaling pathway activities. | EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells.
Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R. | 08/6/2011 |
| not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required | Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila.
Copf T, Goguel V, Lampin-Saint-Amaux A, Scaplehorn N, Preat T., Free PMC Article | 07/16/2011 |
| sumoylation has a repressive role in the regulation of the JAK/STAT pathway | Sumoylation of Drosophila transcription factor STAT92E.
Grönholm J, Ungureanu D, Vanhatupa S, Rämet M, Silvennoinen O. | 05/14/2011 |
| Data show that animals with reduced heterochromatin, such as Stat92E transheterozygotes, Su(var)205 heterozygotes, or Su(var)3-9 transheterozygotes, were less viable than wild-type controls. | Unphosphorylated STAT and heterochromatin protect genome stability.
Yan SJ, Lim SJ, Shi S, Dutta P, Li WX., Free PMC Article | 03/12/2011 |
| Dome signals both from the plasma membrane and internalised vesicles and show, using knockdown experiments, that endocytic components negatively regulate JAK-STAT signalling in vivo | Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.
Vidal OM, Stec W, Bausek N, Smythe E, Zeidler MP., Free PMC Article | 01/29/2011 |