| InR and Pi3K maintain intestinal homeostasis through STAT/EGFR and Notch signaling in enteroblasts. | InR and Pi3K maintain intestinal homeostasis through STAT/EGFR and Notch signaling in enteroblasts.
Wang J, Xue H, Yi X, Kim H, Hao Y, Jin LH. | 07/11/2024 |
| Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene. | Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.
Thompson KD, Suber W, Nicholas R, Arnosti DN., Free PMC Article | 09/7/2023 |
| The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice. | The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.
Wang Y, Lopez-Bellido R, Huo X, Kavelaars A, Galko MJ., Free PMC Article | 06/2/2023 |
| Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function. | Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.
Tatar M., Free PMC Article | 01/8/2022 |
| Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms. | Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.
Yamamoto R, Palmer M, Koski H, Curtis-Joseph N, Tatar M., Free PMC Article | 09/4/2021 |
| Lar physically associates with InR and serves as a negative regulator for insulin signaling in the Drosophila larval hematopoietic niche. | Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche.
Kaur H, Sharma SK, Mandal S, Mandal L., Free PMC Article | 07/11/2020 |
| The authors reveal that transient activation of JNK enhances the expression of the insulin receptor and initiates the insulin-Myc signaling loop to promote mitochondrial respiration and biogenesis by boosting the expression of electron transport chain subunits and of factors essential for mtDNA replication and expression, and for the import of mitochondrial proteins. | Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila.
Wang ZH, Liu Y, Chaitankar V, Pirooznia M, Xu H., Free PMC Article | 03/14/2020 |
| Rab6 promotes localization of the insulin receptor to the plasma membrane. | Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.
Ayala CI, Kim J, Neufeld TP., Free PMC Article | 12/7/2019 |
| Hsp83 functions upstream of the InR/PI3K/Akt pathway during neural stem cell reactivation. | Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation.
Huang J, Wang H., Free PMC Article | 09/21/2019 |
| Immunosenescence in Drosophila suggests its possible mechanisms that involve changes in insulin/IGF-1 signaling. (Review) | Unraveling the Molecular Mechanism of Immunosenescence in Drosophila.
Min KJ, Tatar M., Free PMC Article | 12/22/2018 |
| a sensory neuron-specific function of InR regulates the persistence of injury-associated hypersensitivity. | Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.
Im SH, Patel AA, Cox DN, Galko MJ., Free PMC Article | 11/10/2018 |
| This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR). | Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth.
Luhur A, Buddika K, Ariyapala IS, Chen S, Sokol NS., Free PMC Article | 07/21/2018 |
| Impairment of insulin signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin] | Insulin signalling in mushroom body neurons regulates feeding behaviour in Drosophila larvae.
Zhao XL, Campos AR. | 03/26/2018 |
| it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals. | The insulin-like receptor gene expression in the tissues synthesizing gonadotropic hormones at sexual maturation of Drosophila melanogaster females].
Andreenkova OV, Adonyeva NV, Eremina MA, Gruntenko NE, Rauschenbach IY. | 02/10/2018 |
| INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper. | Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper.
Musashe DT, Purice MD, Speese SD, Doherty J, Logan MA., Free PMC Article | 11/18/2017 |
| These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo. | Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.
Willoughby LF, Manent J, Allan K, Lee H, Portela M, Wiede F, Warr C, Meng TC, Tiganis T, Richardson HE. | 09/30/2017 |
| Mactosylceramide, an early product in GSL biosynthesis, prevents inappropriate activation of insulin and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy. | Mactosylceramide prevents glial cell overgrowth by inhibiting insulin and fibroblast growth factor receptor signaling.
Gerdøe-Kristensen S, Lund VK, Wandall HH, Kjaerulff O. | 09/23/2017 |
| Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor. | The Drosophila insulin receptor independently modulates lifespan and locomotor senescence.
Ismail MZ, Hodges MD, Boylan M, Achall R, Shirras A, Broughton SJ., Free PMC Article | 04/30/2016 |
| Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress | Interplay of insulin and dopamine signaling pathways in the control of Drosophila melanogaster fitness.
Rauschenbach IY, Karpova EK, Alekseev AA, Adonyeva NV, Shumnaya LV, Gruntenko NE. | 01/25/2016 |
| results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep | Regulation of Sleep by Insulin-like Peptide System in Drosophila melanogaster.
Cong X, Wang H, Liu Z, He C, An C, Zhao Z., Free PMC Article | 11/28/2015 |
| This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress. | [Knockdown of InR gene in ventral nephrocytes promotes resistance to toxic stress in Drosophila melanogaster females].
Andreenkova OV, Karpova EK, Menshanov PN, Rauschenbach IY. | 06/20/2015 |
| The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling. | Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher.
O'Farrell F, Wang S, Katheder N, Rusten TE, Samakovlis C., Free PMC Article | 02/15/2014 |
| InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation. | Insulin and Target of rapamycin signaling orchestrate the development of ovarian niche-stem cell units in Drosophila.
Gancz D, Gilboa L. | 12/14/2013 |
| Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. | Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.
Bolukbasi E, Vass S, Cobbe N, Nelson B, Simossis V, Dunbar DR, Heck MM., Free PMC Article | 06/22/2013 |
| Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis | Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila.
Green DA 2nd, Extavour CG. | 03/2/2013 |