| A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression. | A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.
Zhang J, Ye ZW, Bräutigam L, Chakraborty P, Luo Z, Culpepper J, Aslam M, Zhang L, Johansson K, Haeggström JZ, Xu J, Olsson M, Townsend DM, Mehrotra S, Morgenstern R, Tew KD., Free PMC Article | 09/12/2023 |
| Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells. | Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells.
Peng Z, Peng N. | 05/11/2023 |
| MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT). | MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT).
Yang B, Xia S, Ye X, Jing W, Wu B. | 11/22/2021 |
| MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells. | MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells.
Kuang F, Liu J, Xie Y, Tang D, Kang R. | 11/13/2021 |
| MGST1 plays an important role in lung adenocarcinoma (LUAD)tumorigenesis and might serve as a potential prognostic factor and therapeutic target in LUAD. | Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
Zeng B, Ge C, Li R, Zhang Z, Fu Q, Li Z, Lin Z, Liu L, Xue Y, Xu Y, He J, Guo H, Li C, Huang W, Song X, Huang Y. | 06/6/2020 |
| High MGST1 expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma. | Establishment and Characteristics of a Novel Mantle Cell Lymphoma-derived Cell Line and a Bendamustine-resistant Subline.
Takimoto-Shimomura T, Nagoshi H, Maegawa S, Fujibayashi Y, Tsukamoto T, Matsumura-Kimoto Y, Mizuno Y, Chinen Y, Mizutani S, Shimura Y, Horiike S, Taniwaki M, Kobayashi T, Kuroda J., Free PMC Article | 10/27/2018 |
| Significant association for germline variations only in the COX pathway (specifically in the antioxidant microsomal glutathione S-transferase 1 [MGST1] gene), with risk for Barrett's esophagus and the combined outcome of Barrett's esophagus and esophageal adenocarcinoma was found. | Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.
Konda VJA, Souza RF., Free PMC Article | 08/4/2018 |
| This study provides the most comprehensive evaluation of inflammation-related germline variation in relation to risk of BE/OA and suggests that variants in MGST1 influence disease susceptibility. | Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.
Buas MF, He Q, Johnson LG, Onstad L, Levine DM, Thrift AP, Gharahkhani P, Palles C, Lagergren J, Fitzgerald RC, Ye W, Caldas C, Bird NC, Shaheen NJ, Bernstein L, Gammon MD, Wu AH, Hardie LJ, Pharoah PD, Liu G, Iyer P, Corley DA, Risch HA, Chow WH, Prenen H, Chegwidden L, Love S, Attwood S, Moayyedi P, MacDonald D, Harrison R, Watson P, Barr H, deCaestecker J, Tomlinson I, Jankowski J, Whiteman DC, MacGregor S, Vaughan TL, Madeleine MM., Free PMC Article | 09/30/2017 |
| The MSGT1 displays a preexisting dynamic equilibrium between high- and low-activity forms. | Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation.
Spahiu L, Ålander J, Ottosson-Wadlund A, Svensson R, Lehmer C, Armstrong RN, Morgenstern R., Free PMC Article | 09/30/2017 |
| possibly marked variations in NB mitochondrial homeostasis, they also imply that the results of these earlier studies using NB cells are not transferable to other tumor and cell types that express MGST1 at high concentrations. | Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue.
Kelner MJ, Diccianni MB, Yu AL, Rutherford MR, Estes LA, Morgenstern R., Free PMC Article | 11/22/2014 |
| Differential expression of SOD2, ALDH1A1, and MGST1 genes in the anterior lens capsules of patients with pseudoexfoliation syndrome suggest that diseased tissue appears to respond to the previously reported oxidative stress. | Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome.
Strzalka-Mrozik B, Prudlo L, Kimsa MW, Kimsa MC, Kapral M, Nita M, Mazurek U., Free PMC Article | 09/28/2013 |
| The results suggest that MGST1 gene polymorphisms as one of environment gene may contribute to colorectal cancer risk in younger ages. | The role of xenobotic metabolism MGST1 gene polymorphism in colorectal cancer patients.
Akil F, Akil HA, Lutfie AM, Wibowo WS, Miskad U, Yusuf I. | 05/25/2013 |
| MGST1 protects cells (and mitochondria) by both conjugation and glutathione peroxidase functions. A new protective mechanism against cisplatin is also indicated | Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study.
Johansson K, Järvliden J, Gogvadze V, Morgenstern R. | 02/26/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population.
Zhang H, Liao LH, Liu SM, Lau KW, Lai AK, Zhang JH, Wang Q, Chen XQ, Wei W, Liu H, Cai JH, Lung ML, Tai SS, Wu M. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.
Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA, Olson L, Kenealy SJ, Hauser M, Gilbert JR, Pericak-Vance MA. | 03/13/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis.
Schneider A, Tögel S, Barmada MM, Whitcomb DC. | 03/13/2008 |
| Genes encoding KU70, MGST1 and BIK show age-related mRNA expression levels in hematopoietic stem cells. | Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.
Prall WC, Czibere A, Jäger M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M. | 01/21/2010 |
| The results indicate that Sp1 is the protein mediating the basal transcription of MGST1 | Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3.
Ekström L, Lyrenäs L, Jakobsson PJ, Morgenstern R, Kelner MJ. | 01/21/2010 |
| As an addition to the high-density SNP (single-nucleotide polymorphism) maps of 12 glutathione S-transferase and related genes reported earlier, a SNP map of the microsomal glutathione S-transferase 1 (MGST1) gene is provided. | Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene.
Iida A, Saito S, Sekine A, Harigae S, Osawa S, Mishima C, Kondo K, Kitamura Y, Nakamura Y. | 10/20/2001 |