| Interplay between autophagy and CncC regulates dendrite pruning in Drosophila. | Interplay between autophagy and CncC regulates dendrite pruning in Drosophila.
Tan JYK, Chew LY, Juhász G, Yu F., Free PMC Article | 02/29/2024 |
| Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling. | Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
Gumeni S, Lamprou M, Evangelakou Z, Manola MS, Trougakos IP., Free PMC Article | 12/1/2023 |
| Determination of Complex Formation between Drosophila Nrf2 and GATA4 Factors at Selective Chromatin Loci Demonstrates Transcription Coactivation. | Determination of Complex Formation between Drosophila Nrf2 and GATA4 Factors at Selective Chromatin Loci Demonstrates Transcription Coactivation.
Neidviecky E, Deng H., Free PMC Article | 04/12/2023 |
| Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status. | Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
Langton PF, Baumgartner ME, Logeay R, Piddini E., Free PMC Article | 02/19/2022 |
| Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models. | Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
Guo Q, Wang B, Wang X, Smith WW, Zhu Y, Liu Z., Free PMC Article | 11/22/2021 |
| Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes. | Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes.
Gumeni S, Papanagnou ED, Manola MS, Trougakos IP., Free PMC Article | 09/25/2021 |
| Preserving transcriptional stress responses as an anti-aging strategy. | Preserving transcriptional stress responses as an anti-aging strategy.
Cheng Y, Pitoniak A, Wang J, Bohmann D., Free PMC Article | 09/11/2021 |
| Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster. | Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster.
Bayliak MM, Demianchuk OI, Gospodaryov DV, Abrat OB, Lylyk MP, Storey KB, Lushchak VI. | 07/10/2021 |
| increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila activated cytoprotective modules and enhanced stress tolerance. | Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.
Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP., Free PMC Article | 04/4/2020 |
| Study shows that Drosophila CncC links cell cycle control with proteostatic responses in intestinal stem cells via the accumulation of dacapo, a p21 cell cycle inhibitor homologue, as well as the transcriptional activation of genes encoding proteases and proteasome subunits. | Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction.
Rodriguez-Fernandez IA, Qi Y, Jasper H., Free PMC Article | 04/6/2019 |
| Together with the facts that Maf-S regulates ROS levels and genetically interacts with Keap1/Nrf2 in GSC maintenance, our study suggests that Maf-S plays an important role in the Drosophila testis GSC maintenance by participating in the regulation of redox homeost | Small Maf functions in the maintenance of germline stem cells in the Drosophila testis.
Tan SWS, Yip GW, Suda T, Baeg GH., Free PMC Article | 10/13/2018 |
| continual knockdown of Keep1 (the cytosolic inhibitor of Cnc-C) in adults resulted in older flies with greater stress resistance than their age-matched controls, but who still exhibited an age-associated loss of adaptive homeostasis | The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster.
Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA., Free PMC Article | 02/17/2018 |
| Cnc is required for tissue regeneration. Cnc regulates reactive oxygen species levels in the regenerating wing imaginal disc, and affects JNK signaling. | Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc.
Brock AR, Seto M, Smith-Bolton RK., Free PMC Article | 10/21/2017 |
| Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism. | Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.
Lin CH, Lin HI, Chen ML, Lai TT, Cao LP, Farrer MJ, Wu RM, Chien CT. | 07/29/2017 |
| Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap 'n' collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies. Our observations indicate that activation of the Nrf1/Nrf2 pathway is a viable option for pharmacological intervention in SBMA and potentially other polyglutamine diseases. | A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.
Bott LC, Badders NM, Chen KL, Harmison GG, Bautista E, Shih CC, Katsuno M, Sobue G, Taylor JP, Dantuma NP, Fischbeck KH, Rinaldi C., Free PMC Article | 07/29/2017 |
| Data suggest that blocking the specific interaction of Nrf2/cncC (cap-n-collar isoform C) with Keap1 may provide an exciting new avenue for the discovery of disease-modifying treatments for Alzheimer's disease (AD) and potentially other neurodegenerative conditions. | Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L., Free PMC Article | 06/24/2017 |
| Consistent with the independent modes of CncC regulation by Keap1 and Fs(1)h, combinations of drugs that can specifically target these pathways cause a strong synergistic and specific activation of protective CncC- dependent gene expression and boosts oxidative stress resistance. | Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.
Chatterjee N, Tian M, Spirohn K, Boutros M, Bohmann D., Free PMC Article | 05/13/2017 |
| Selective expression of the Nrf2 homologous gene cncC in the dopaminergic neurons effectively protected against the neurodegenerative phenotype of the A53T alpha-synuclein flies, compared to the flies that expressed cncC in all neurons | Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila.
Wang B, Liu Q, Shan H, Xia C, Liu Z. | 05/21/2016 |
| CncCDeltaN induced a number of genes related to innate immunity that might have an effect on the regulation of cellular lipid storage | Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body.
Karim MR, Taniguchi H, Kobayashi A. | 11/7/2015 |
| cooperatively activate developmental genes, in contrast to their conserved antagonizing effect to xenobiotic response transcription | Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms.
Deng H., Free PMC Article | 11/29/2014 |
| dKeap1 and CncC have a xenobiotic-specific gene activation response due to their combinatorial chromatin-binding specificities and transcriptional activities | Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.
Deng H, Kerppola TK., Free PMC Article | 10/18/2014 |
| The maintenance of acute stress resistance, motor function, and heart performance in aging flies overexpressing MafS supports a critical role for signal responsiveness of Nrf2 function in promoting youthful phenotypes. | Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.
Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D., Free PMC Article | 12/21/2013 |
| Upregulation of the Nrf2 pathway by overexpressing Nrf2 or its DNA-binding dimerization partner, Maf-S, restores the locomotor activity of alpha-synuclein-expressing flies. | Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.
Barone MC, Sykiotis GP, Bohmann D., Free PMC Article | 04/29/2013 |
| Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the 26S proteasome. | Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome.
Grimberg KB, Beskow A, Lundin D, Davis MM, Young P., Free PMC Article | 03/5/2011 |