| Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification. | Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification.
Lin L, Huang Z, Li W, Liu X, Li X, Gao S, Chen J, Yang C, Min X, Yang H, Gong Q, Wei Y, Tu S, Rao X, Zhang Z, Dong L, Zhong J. | 07/10/2024 |
| Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1. | Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1.
Wang Y., Free PMC Article | 04/3/2024 |
| Absence of the RING domain in MID1 results in patterning defects in the developing human brain. | Absence of the RING domain in MID1 results in patterning defects in the developing human brain.
Frank S, Gabassi E, Käseberg S, Bertin M, Zografidou L, Pfeiffer D, Brennenstuhl H, Falk S, Karow M, Schweiger S., Free PMC Article | 02/1/2024 |
| Opitz GBBB syndrome with total anomalous pulmonary venous connection: A new MID1 gene variant. | Opitz GBBB syndrome with total anomalous pulmonary venous connection: A new MID1 gene variant.
Perea-Cabrera M, Granados-Riveron JT, Segura-Stanford B, Moreno-Vargas LM, Prada-Gracia D, Moran-Espinosa MC, Erdmenger J, Diaz-Garcia H, Sánchez-Urbina R., Free PMC Article | 09/18/2023 |
| Irradiated lung cancer cell-derived exosomes modulate macrophage polarization by inhibiting MID1 via miR-4655-5p. | Irradiated lung cancer cell-derived exosomes modulate macrophage polarization by inhibiting MID1 via miR-4655-5p.
Chen X, Wang L, Yu H, Shen Q, Hou Y, Xia YX, Li L, Chang L, Li WH. | 03/14/2023 |
| B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases. | B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases.
Kaur A, Gladu EM, Wright KM, Webb JA, Massiah MA. | 03/9/2023 |
| The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells. | The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells.
Rezig IM, Yaduma WG, Gould GW, McInerny CJ., Free PMC Article | 03/3/2023 |
| TRIM18 is a critical regulator of viral myocarditis and organ inflammation. | TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Fang M, Zhang A, Du Y, Lu W, Wang J, Minze LJ, Cox TC, Li XC, Xing J, Zhang Z., Free PMC Article | 08/6/2022 |
| Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3. | Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J., Free PMC Article | 10/2/2021 |
| Hydrothorax in fetal cases of Opitz G/BBB diagnosis: Extending the phenotype? | Hydrothorax in fetal cases of Opitz G/BBB diagnosis: Extending the phenotype?
Tessier A, Boutaud L, Bruel AL, Thauvin-Robinet C, Roth P, Malan V, Beaujard MP, Achaiaa A, de Oliveira J, Steffann J, Encha-Razavi F, Faivre L, Bessières B, Attié-Bitach T. | 08/21/2021 |
| The expression levels of OSX and S100A4 correlated significantly in human breast tumors. | Osterix promotes the migration and angiogenesis of breast cancer by upregulation of S100A4 expression.
Qu S, Wu J, Bao Q, Yao B, Duan R, Chen X, Li L, Yuan H, Jin Y, Ma C., Free PMC Article | 06/20/2020 |
| TRAIL in serum and MID1 protein levels in biopsies from Idiopathic pulmonary fibrosis patients were increased compared to controls. TRAIL signalling through MID1 deactivates protein phosphatase 2A and promotes fibrosis with corresponding lung function decline. | TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.
Collison AM, Li J, de Siqueira AP, Lv X, Toop HD, Morris JC, Starkey MR, Hansbro PM, Zhang J, Mattes J., Free PMC Article | 06/8/2019 |
| Data show that protein phosphatase-2A (PP2A) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 E3 ubiquitin-protein ligase (MID1)-siRNA, suggesting MID1 negatively regulates PP2A in lung adenocarcinoma. | MID1-PP2A complex functions as new insights in human lung adenocarcinoma.
Zhang L, Li J, Lv X, Guo T, Li W, Zhang J. | 05/12/2018 |
| identified four miRNAs, miR-19, miR-340, miR-374 and miR-542 that bind to the 3'-UTR of the MID1 mRNA. These miRNAs not only regulate MID1 expression but also mTOR signaling and translation of disease associated mRNAs and could therefore serve as potential drugs for future therapy development | MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression.
Unterbruner K, Matthes F, Schilling J, Nalavade R, Weber S, Winter J, Krauß S., Free PMC Article | 02/24/2018 |
| Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 presence, and likely its activity, within nuclear and cytoplasmic compartments | The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35.
Zanchetta ME, Napolitano LMR, Maddalo D, Meroni G. | 12/9/2017 |
| P151L MID1 mutation is associated with X-linked Opitz Syndrome. | Structural and functional observations of the P151L MID1 mutation reveal alpha4 plays a significant role in X-linked Opitz Syndrome.
Wright KM, Du H, Massiah MA. | 09/30/2017 |
| the coiled-coil and COS domain (CC-COS) bind to microtubules, demonstrating for the first time that MID1 can directly associate with the microtubules | Solution structure of the microtubule-targeting COS domain of MID1.
Wright KM, Du H, Dagnachew M, Massiah MA. | 06/24/2017 |
| Osx is upregulated in patients with Ossification of the posterior longitudinal ligament. | Ossification of the posterior ligament is mediated by osterix via inhibition of the β-catenin signaling pathway.
Shi L, Cai G, Shi J, Guo Y, Chen D, Chen D, Yang H. | 05/20/2017 |
| A130T/V mutations within the MID1 zinc-binding Bbox1 domain affects protein folding. | Molecular dynamics simulation reveals insights into the mechanism of unfolding by the A130T/V mutations within the MID1 zinc-binding Bbox1 domain.
Zhao Y, Zeng C, Massiah MA., Free PMC Article | 04/30/2016 |
| MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome. | MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.
Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA., Free PMC Article | 04/2/2016 |
| TRAIL regulates MID1 and TSLP, inflammation, fibrosis, smooth muscle hypertrophy, and expression of inflammatory effector chemokines and cytokines in experimental eosinophilic esophagitis. | TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis.
Collison AM, Sokulsky LA, Sherrill JD, Nightingale S, Hatchwell L, Talley NJ, Walker MM, Rothenberg ME, Mattes J., Free PMC Article | 01/23/2016 |
| These studies provide insight into the mechanism by which mutations observed in X-linked Opitz G syndrome affect the structure and function of the MID1 Bbox1 domain | XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding.
Wright KM, Wu K, Babatunde O, Du H, Massiah MA., Free PMC Article | 12/19/2015 |
| A familial c.1102C>T (p.R368X) mutation in the MID1 gene, is reported. | R368X mutation in MID1 among recurrent mutations in patients with X-linked Opitz G/BBB syndrome.
Preiksaitiene E, Krasovskaja N, Utkus A, Kasnauskiene J, Meškienė R, Paulauskiene I, Valevičienė NR, Kučinskas V. | 07/25/2015 |
| Results revealed S422 as a novel phosphorylation site of Osx and GSK-3b played an important role in regulating the protein stability and transactivational activity of Osx. | Phosphorylation of Serine422 increases the stability and transactivation activities of human Osterix.
Xu Y, Yao B, Shi K, Lu J, Jin Y, Qi B, Li H, Pan S, Chen L, Ma C. | 05/23/2015 |
| Fu ubiquitination and cleavage is one of the key elements connecting the MID1-PP2A protein complex with GLI3 activity control | The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S., Free PMC Article | 01/24/2015 |