| mitochondrial energy production, Nrg/Ank2, branched actin generated by Arp2/3 and Fz/G proteins/Axin function as four modules that control localization of the microtubule regulator Apc2 to its site of action in dendrite branch points. | Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites.
Weiner AT, Seebold DY, Michael NL, Guignet M, Feng C, Follick B, Yusko BA, Wasilko NP, Torres-Gutierrez P, Rolls MM., Free PMC Article | 11/10/2018 |
| Data suggest that brain tumor protein (Brat) promotes midline crossing through directing the localization or stability of Adenomatous polyposis coli-2 (Apc2) at the plus ends of microtubules in navigating commissural axons. | Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2.
Arbeille E, Bashaw GJ., Free PMC Article | 06/30/2018 |
| This study provides new perspectives on the cellular effects of APC that might lead to a deeper understanding of its role in development. | Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin.
Blundon MA, Schlesinger DR, Parthasarathy A, Smith SL, Kolev HM, Vinson DA, Kunttas-Tatli E, McCartney BM, Minden JS., Free PMC Article | 09/9/2017 |
| APC2 self-association is required for WNT destructosome activity in the Drosophila embryo. | Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.
Kunttas-Tatli E, Roberts DM, McCartney BM., Free PMC Article | 10/3/2015 |
| Germline specific overexpression of Adenomatous Polyposis Coli 2 rescued germline stem cell loss in chic hypomorphs, suggesting an additive role of APC2 and F-actin in maintaining the adherens junctions that anchor germline stem cells to the niche. | The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.
Shields AR, Spence AC, Yamashita YM, Davies EL, Fuller MT., Free PMC Article | 03/15/2014 |
| APC2 protects genome stability by modulating mitotic fidelity through regulation of the cytoskeleton. | APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation.
Poulton JS, Mu FW, Roberts DM, Peifer M., Free PMC Article | 12/14/2013 |
| These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. | Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.
Roberts DM, Pronobis MI, Poulton JS, Kane EG, Peifer M., Free PMC Article | 09/29/2012 |
| Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2. | Drosophila apc regulates delamination of invasive epithelial clusters.
De Graeve FM, Van de Bor V, Ghiglione C, Cerezo D, Jouandin P, Ueda R, Shashidhara LS, Noselli S. | 09/22/2012 |
| Data show that although cortical localization is required for the APC2 function in organizing actin, cortical localization is dispensable for its role in regulating Wnt signaling. | Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila.
Zhou MN, Kunttas-Tatli E, Zimmerman S, Zhouzheng F, McCartney BM., Free PMC Article | 09/24/2011 |
| APC2 and DIA function in a novel complex that affects actin directly, rather than through an effect on microtubules | A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila.
Webb RL, Zhou MN, McCartney BM., Free PMC Article | 01/21/2010 |
| Apc activity is not present in vast excess, but instead is near the minimal level required for accurate graded responses to the Wingless morphogen. | Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen.
Benchabane H, Hughes EG, Takacs CM, Baird JR, Ahmed Y. | 01/21/2010 |
| findings demonstrate that Drosophila Apc homologs have an activating role in both physiological and ectopic Wingless signaling; Apc likely promotes Wingless transduction through down-regulation of Axin, a negative regulator of Wingless signaling | Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.
Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y. | 01/21/2010 |
| results show that dividing male germline stem cells use mechanisms involving centrosome function and cortically localized APC to orient mitotic spindles ensuring an asymmetric outcome in which one cell self renews and the other initiates differentiation | Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.
Yamashita YM, Jones DL, Fuller MT. | 01/21/2010 |
| Results show that although complete loss of APC1 and APC2 resulted in activation of Wingless signaling, it did not alter cell viability, cadherin-based adhesion, spindle morphology, orientation or selection of division plane, as predicted. | Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila.
McCartney BM, Price MH, Webb RL, Hayden MA, Holot LM, Zhou M, Bejsovec A, Peifer M. | 01/21/2010 |
| Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. | Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs.
Akong K, Grevengoed EE, Price MH, McCartney BM, Hayden MA, DeNofrio JC, Peifer M. | 01/21/2010 |
| APC1 and APC2 play functionally redundant roles in brain development | Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations.
Akong K, McCartney BM, Peifer M. | 01/21/2010 |
| Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. | Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
Ahmed Y, Nouri A, Wieschaus E. | 01/21/2010 |