| Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes. | Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes.
Liu X, Liu L, Wu A, Huang S, Xu Z, Zhang X, Li Z, Li H, Dong J., Free PMC Article | 02/15/2024 |
| Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols. | Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols.
Hamad SH, Brinkman MC, Tsai YH, Mellouk N, Cross K, Jaspers I, Clark PI, Granville CA., Free PMC Article | 07/31/2021 |
| Recognition of 1,N (2)-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue. | Recognition of 1,N(2)-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue.
Thelen AZ, O'Brien PJ., Free PMC Article | 10/24/2020 |
| AAG binds to chromatin and forms complex with RNA polymerase (pol) II. This occurs through direct interaction with Elongator and results in transcriptional co-regulation. | Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Montaldo NP, Bordin DL, Brambilla A, Rösinger M, Fordyce Martin SL, Bjørås KØ, Bradamante S, Aas PA, Furrer A, Olsen LC, Kunath N, Otterlei M, Sætrom P, Bjørås M, Samson LD, van Loon B., Free PMC Article | 03/14/2020 |
| Although AAG strongly prefers to excise lesions from duplex DNA, nonspecific binding is comparable for single- and double-stranded nonspecific sites. The electrostatically driven binding of AAG to small DNA sites ( approximately 5 nucleotides of single-stranded and approximately 6 base pairs of duplex) facilitates the search for DNA damage in chromosomal DNA, which is bound by nucleosomes and other proteins. | Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase.
Taylor EL, Kesavan PM, Wolfe AE, O'Brien PJ., Free PMC Article | 06/29/2019 |
| PIG11 may act as a candidate liver tumor suppressor. | PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway.
Wang Y, Liu X, Liu G, Wang X, Hu R, Liang X. | 03/2/2019 |
| high levels of APNG were associated with better overall survival in patients with glioblastoma | APNG as a prognostic marker in patients with glioblastoma.
Fosmark S, Hellwege S, Dahlrot RH, Jensen KL, Derand H, Lohse J, Sørensen MD, Hansen S, Kristensen BW., Free PMC Article | 11/4/2017 |
| Data indicate that DNA glycosylases MYH, UNG2, MPG, NTH1, NEIL1, 2 and 3 on nascent DNA. | Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Bj Rås KØ, Sousa MML, Sharma A, Fonseca DM, S Gaard CK, Bj Rås M, Otterlei M., Free PMC Article | 10/28/2017 |
| Data suggest that the change in tryptophan fluorescence of Y162W mutant of AAG (alkyladenine DNA glycosylase) is extremely rapid upon binding to either damaged or undamaged DNA, much faster than lesion-recognition and nucleotide flipping steps; thus, intercalation by tyrosine may be one of the earliest steps in search for/recognition of DNA damage. | Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue.
Hendershot JM, O'Brien PJ., Free PMC Article | 10/21/2017 |
| Rheumatoid arthritis is associated with a polymorphism in the MPG gene (rs2858056) and increased serum level of the MPG protein. | Effect of MPG gene rs2858056 polymorphism, copy number variation, and level of serum MPG protein on the risk for rheumatoid arthritis.
Huang CM, Chen SY, Huang PH, Tsai FJ., Free PMC Article | 01/16/2016 |
| Role of MPG protein in the DNA damage response through the base excision repair pathway | Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
Chou WC, Hu LY, Hsiung CN, Shen CY. | 10/24/2015 |
| results suggest that individuals carrying R120C and R141Q MPG variants may be at risk for genomic instability and associated diseases as a consequence. | Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations.
Adhikari S, Chetram MA, Woodrick J, Mitra PS, Manthena PV, Khatkar P, Dakshanamurthy S, Dixon M, Karmahapatra SK, Nuthalapati NK, Gupta S, Narasimhan G, Mazumder R, Loffredo CA, Üren A, Roy R., Free PMC Article | 05/9/2015 |
| Elevated MPG activity is associated with lung cancer, possibly by creating an imbalance in the base excision repair pathway. | Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer.
Crosbie PA, Watson AJ, Agius R, Barber PV, Margison GP, Povey AC. | 05/2/2015 |
| In the case of alkyladenine DNA glycosylase, DNA intercalation contributes to the specific binding of a damaged nucleotide, but this enhanced specificity comes at the cost of reduced speed of nucleotide flipping. | Critical role of DNA intercalation in enzyme-catalyzed nucleotide flipping.
Hendershot JM, O'Brien PJ., Free PMC Article | 04/4/2015 |
| High MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk. | Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk.
Leitner-Dagan Y, Sevilya Z, Pinchev M, Kremer R, Elinger D, Rennert HS, Schechtman E, Freedman L, Rennert G, Livneh Z, Paz-Elizur T., Free PMC Article | 02/21/2015 |
| disease-stage-specific alterations in the expression of MPG may highlight a potential role for MPG in determining EAC onset and thus potentially be of clinical relevance for early disease detection and increased patient survival. | Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.
Zaïr ZM, Johnson GE, Griffiths AP, Jenkins GJ. | 03/29/2014 |
| AAG has a flexible amino terminus that tunes its affinity for nonspecific DNA, but we find that it is not required for intersegmental transfer. As AAG has only a single DNA binding site, this argues against the bridging model for intersegmental transfer | Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase.
Hedglin M, Zhang Y, O'Brien PJ., Free PMC Article | 11/16/2013 |
| AAG removes both methanol and 1,N(6)-ethenoadenine from DNA with single-turnover rate constants that are significantly greater than the corresponding uncatalyzed rates. | DNA-N-glycosylases process novel O-glycosidic sites in DNA.
Admiraal SJ, O'Brien PJ., Free PMC Article | 08/31/2013 |
| Mitochondrial single-stranded binding protein (mtSSB) as a novel interacting partner of AAG. | Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).
van Loon B, Samson LD., Free PMC Article | 08/10/2013 |
| UHRF1 interacts with N-methylpurine DNA glycosylase (MPG) in cancer cells in vitro and displays a co-localization with MPG in the nucleoplasm. | Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.
Liang C, Zhang X, Song S, Tian C, Yin Y, Xing G, He F, Zhang L. | 06/15/2013 |
| A functional footprinting approach was used to define the binding site of alkyladenine DNA glycosylase used for the repair of deaminated purines. | Defining the functional footprint for recognition and repair of deaminated DNA.
Baldwin MR, O'Brien PJ., Free PMC Article | 02/23/2013 |
| N-methylpurine DNA glycosylase negatively regulates p53-mediated cell cycle arrest. | N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.
Song S, Xing G, Yuan L, Wang J, Wang S, Yin Y, Tian C, He F, Zhang L., Free PMC Article | 12/22/2012 |
| AAG can make damaged DNA by catalyzing formation of an N-glycosyl bond between 1,N(6)-ethenoadenine (epsilonA) and abasic DNA. We attribute the reversibility of this reaction to the tight binding and slow subsequent hydrolysis of DNA containing an epsilonA lesion. | N-glycosyl bond formation catalyzed by human alkyladenine DNA glycosylase.
Admiraal SJ, O'Brien PJ., Free PMC Article | 11/24/2012 |
| Investigated the expression of MPG gene and protein in 128 glioma and 10 non-neoplastic brain tissues. Found MPG gene expression level in glioma tissues was significantly higher than that in non-neoplastic brain tissues (P < 0.001). | Aberrant expression of N-methylpurine-DNA glycosylase influences patient survival in malignant gliomas.
Liu C, Tu Y, Yuan J, Mao X, He S, Wang L, Fu G, Zong J, Zhang Y., Free PMC Article | 09/8/2012 |
| The non-enzymatic binding of AAG to 3,N(4)-ethenocytosine specifically blocks ALKBH2-catalyzed repair of 3,N(4)-ethenocytosine but not that of methylated ALKBH2 substrates. | Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.
Fu D, Samson LD., Free PMC Article | 08/11/2012 |