| Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila. | Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila.
Brown JL, Price JD, Erokhin M, Kassis JA., Free PMC Article | 08/10/2023 |
| Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene. | Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
Ghotbi E, Lackey K, Wong V, Thompson KT, Caston EG, Haddadi M, Benes J, Jones RS., Free PMC Article | 01/23/2021 |
| Mutation in the protein-protein interaction domain (REPO domain) of Pho interferes with the dynamics of its interaction with Spt5. The transcriptional kinetics of the heat shock response is negatively affected by a mutation in the REPO domain of Pho | Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus.
Pereira A, Paro R., Free PMC Article | 03/10/2018 |
| Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho) | Pleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in Drosophila.
Harvey R, Schuster E, Jennings BH., Free PMC Article | 03/1/2014 |
| even-skipped genes were misexpressed in pho mutant embryos | The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis.
Kim SN, Shim HP, Jeon BN, Choi WI, Hur MW, Girton JR, Kim SH, Jeon SH., Free PMC Article | 04/21/2012 |
| The TF homolog pair Pho/Yy1 seems to play very different roles in PcG targeting between Drosophila and mouse. | Prediction of Polycomb target genes in mouse embryonic stem cells.
Liu Y, Shao Z, Yuan GC. | 10/23/2010 |
| CtBP regulates expression of intergenic transcripts that controls DNA binding by PcG proteins and subsequent histone modifications and transcriptional activity. | CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA.
Basu A, Atchison ML., Free PMC Article | 07/26/2010 |
| a DNA-binding complex requiring Pho is differentially regulated to facilitate epigenetic transcriptional memory of both the active and the repressed state | The DNA-binding Polycomb-group protein Pleiohomeotic maintains both active and repressed transcriptional states through a single site.
Fujioka M, Yusibova GL, Zhou J, Jaynes JB., Free PMC Article | 01/21/2010 |
| Pho is a general component of the maintenance machinery, since the majority of Pc targets are also associated with Pho (Pleiohomeotic )binding. | Stability and dynamics of polycomb target sites in Drosophila development.
Kwong C, Adryan B, Bell I, Meadows L, Russell S, Manak JR, White R., Free PMC Article | 01/21/2010 |
| These results suggest that pho functions in maintaining expression of genes involved in the formation of ventral appendages and the proximo-distal axis. | The pleiohomeotic gene is required for maintaining expression of genes functioning in ventral appendage formation in Drosophila melanogaster.
Kim SN, Jung KI, Chung HM, Kim SH, Jeon SH. | 01/21/2010 |
| grainyhead interacts genetically with pleiohomeotic in a transgene-based, pairing-dependent silencing assay | Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic.
Blastyák A, Mishra RK, Karch F, Gyurkovics H., Free PMC Article | 01/21/2010 |
| Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to polycomb response elements | Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex.
Mohd-Sarip A, Cléard F, Mishra RK, Karch F, Verrijzer CP., Free PMC Article | 01/21/2010 |
| Pleiohomeotic protein has a role in polycomb response element-mediated silencing for transcriptional repression | Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression.
Mohd-Sarip A, Venturini F, Chalkley GE, Verrijzer CP., Free PMC Article | 01/21/2010 |
| YY1 sequences 201-226 are necessary and sufficient for Polycomb group transcriptional repression in vivo. | Polycomb recruitment to DNA in vivo by the YY1 REPO domain.
Wilkinson FH, Park K, Atchison ML., Free PMC Article | 01/21/2010 |
| This protein functions as a PcG protein in vivo. | Transcription factor YY1 functions as a PcG protein in vivo.
Atchison L, Ghias A, Wilkinson F, Bonini N, Atchison ML., Free PMC Article | 01/21/2010 |
| The mammalian transcription factor YY1 can function as a PcG protein in Drosophila resulting in transcriptional repression and correction of phenotypic defects caused by mutation of its homologue, Pleiohomeotic (PHO). | Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue.
Srinivasan L, Pan X, Atchison ML. | 01/21/2010 |
| These results suggest that Pho and Pho-like, a gene encoding a protein with high similarity to Pho, act redundantly to repress homeotic genes. | The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing.
Brown JL, Fritsch C, Mueller J, Kassis JA. | 01/21/2010 |