| Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. | Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
Borkowsky S, Gass M, Alavizargar A, Hanewinkel J, Hallstein I, Nedvetsky P, Heuer A, Krahn MP., Free PMC Article | 03/15/2023 |
| A conserved role for AMP-activated protein kinase in NGLY1 deficiency. | A conserved role for AMP-activated protein kinase in NGLY1 deficiency.
Han SY, Pandey A, Moore T, Galeone A, Duraine L, Cowan TM, Jafar-Nejad H., Free PMC Article | 01/23/2021 |
| Data (including data from transgenic flies) suggest that SNF1A is involved in neuroprotection in this species; AMPK activation in glia (but not neurons) reduces severity of ionic disruption and prolongs recovery of electrical activity in brains of flies in starvation-induced anoxia. | AMP-activated protein kinase protects against anoxia in Drosophila melanogaster.
Evans JJ, Xiao C, Robertson RM. | 05/5/2018 |
| AMPK can function outside of its canonical nutrient-sensing role in specific developmental contexts. | AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis.
Laws KM, Drummond-Barbosa D., Free PMC Article | 06/10/2017 |
| The significance of these findings is that AMPK is important in the regulation of glucagon signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks. | Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase.
Braco JT, Gillespie EL, Alberto GE, Brenman JE, Johnson EC., Free PMC Article | 04/13/2013 |
| Loss of AMPK activity exacerbates neuronal loss and associated phenotypes in parkin and LRRK transgenic flies. | AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease.
Ng CH, Guan MS, Koh C, Ouyang X, Yu F, Tan EK, O'Neill SP, Zhang X, Chung J, Lim KL., Free PMC Article | 01/5/2013 |
| Data suggest that that an Sgt1/Hsp90-LKB1-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors. | Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.
Andersen RO, Turnbull DW, Johnson EA, Doe CQ., Free PMC Article | 05/26/2012 |
| AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors. | Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila.
Johnson EC, Kazgan N, Bretz CA, Forsberg LJ, Hector CE, Worthen RJ, Onyenwoke R, Brenman JE., Free PMC Article | 02/26/2011 |
| AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut | AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut.
Bland ML, Lee RJ, Magallanes JM, Foskett JK, Birnbaum MJ., Free PMC Article | 08/16/2010 |
| These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance. | A critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogaster.
Tohyama D, Yamaguchi A. | 05/3/2010 |
| LKB1 and AMPK have roles in cell polarity and division [review] | LKB1 and AMPK in cell polarity and division.
Williams T, Brenman JE. | 01/21/2010 |
| results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures | Energy-dependent regulation of cell structure by AMP-activated protein kinase.
Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, Lee SH, Shong M, Kim JM, Kim J, Chung J. | 01/21/2010 |
| activated by AMP in cell-free assays and by stresses that deplete ATP; the phosphorylated DmAMPK alpha subunit was mainly detected in the nucleus | A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion.
Pan DA, Hardie DG., Free PMC Article | 01/21/2010 |