| The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila. | The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila.
Li Y, Liu D, Wang H, Zhang X, Lu B, Li S. | 02/20/2024 |
| Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1. | Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
Martínez Corrales G, Li M, Svermova T, Goncalves A, Voicu D, Dobson AJ, Southall TD, Alic N., Free PMC Article | 08/24/2023 |
| Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay. | Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.
Cairrão F, Santos CC, Le Thomas A, Marsters S, Ashkenazi A, Domingos PM., Free PMC Article | 07/16/2022 |
| X-box binding protein 1 overexpression at an early stage reversed Abeta-induced early death without affecting learning performance in the Abeta42 transgenic flies. PERK activation was determined to only enhance Abeta-induced learning deficits. | XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology.
Cheng KC, Chiang HC. | 02/9/2019 |
| XBP1-independent IRE1 RNase activity, while challenging the importance of RNase-independent effector mechanisms of Drosophila IRE1 function. | The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.
Huang HW, Zeng X, Rhim T, Ron D, Ryoo HD., Free PMC Article | 06/9/2018 |
| Its activation is neuroprotective and enhances Abeta42 clearance. | Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain.
Marcora MS, Belfiori-Carrasco LF, Bocai NI, Morelli L, Castaño EM. | 01/6/2018 |
| Ire1-dependent splicing of Xbp1 mRNA is reduced. | Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1.
Coelho DS, Gaspar CJ, Domingos PM., Free PMC Article | 12/19/2015 |
| role of Ire1 during photoreceptor differentiation is independent of Xbp1 function and demonstrate the physiological relevance of the RIDD mechanism in this specific paradigm. | Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila.
Coelho DS, Cairrão F, Zeng X, Pires E, Coelho AV, Ron D, Ryoo HD, Domingos PM., Free PMC Article | 08/30/2014 |
| The XBP1 promoter activity is enhanced in secretory tissues of Drosophila, and can be induced by excessive endoplasmic reticulum stress. | Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load.
Ryoo HD, Li J, Kang MJ., Free PMC Article | 05/17/2014 |
| In the larval brain, IRE1/XBP1 activity was detected exclusively in glia, although previous reports have largely focused on IRE1/XBP1 activity in neurons. | A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.
Sone M, Zeng X, Larese J, Ryoo HD., Free PMC Article | 11/23/2013 |
| These results underscore the functional relevance of XBP1s in Abeta toxicity, and uncover the potential of XBP1 and ryanodine receptor as targets for Alzheimer's disease therapeutics. | The ER stress factor XBP1s prevents amyloid-beta neurotoxicity.
Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P., Free PMC Article | 08/27/2011 |
| encodes a "bZIP"-containing transcription factor that plays a key role in the unfolded protein response (UPR), an evolutionarily conserved signalling pathway | The xbp-1 gene is essential for development in Drosophila.
Souid S, Lepesant JA, Yanicostas C. | 01/21/2010 |