| The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes. | The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Mysh M, Poulton JS., Free PMC Article | 10/9/2021 |
| Distinct activities of Scrib module proteins organize epithelial polarity. | Distinct activities of Scrib module proteins organize epithelial polarity.
Khoury MJ, Bilder D., Free PMC Article | 08/22/2020 |
| such Egr-induced necrosis depends on the catalytic activity of the initiator caspase Dronc and the input from JNK signaling but is independent of their roles in apoptosis. Further mosaic analysis with mutants of scribble (scrib), suggests that Egr/JNK-mediated apoptosis and necrosis establish a two-layered defense system to inhibit the oncogenic growth of scrib mutant cells | Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.
Li M, Sun S, Priest J, Bi X, Fan Y., Free PMC Article | 08/1/2020 |
| An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila. | An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila.
Kushnir T, Bar-Cohen S, Mooshayef N, Lange R, Bar-Sinai A, Rozen H, Salzberg A, Engelberg D, Paroush Z., Free PMC Article | 07/11/2020 |
| the Scribble/Dlg module plays multiple roles in polarity initiation | Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.
Bonello TT, Choi W, Peifer M., Free PMC Article | 07/11/2020 |
| Scrib and Dlg are key components of the tricellular junction. | Scribble and Discs Large mediate tricellular junction formation.
Sharifkhodaei Z, Gilbert MM, Auld VJ. | 06/27/2020 |
| Here we show that the crucial role for Scrib in apicobasal polarity has remained obscure due to the compensatory function of two other LAP proteins, Erbin and Lano. | Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex.
Choi J, Troyanovsky RB, Indra I, Mitchell BJ, Troyanovsky SM., Free PMC Article | 05/16/2020 |
| dynamic MAPK signaling activity, fueled by intratumor heterogeneity derived from tissue topological differences, drives a growth arrest-to-proliferation transition in scrib mutant tumors. | Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors.
Ji T, Zhang L, Deng M, Huang S, Wang Y, Pham TT, Smith AA, Sridhar V, Cabernard C, Wang J, Yan Y., Free PMC Article | 04/11/2020 |
| Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation. | Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation.
Bonello TT, Peifer M., Free PMC Article | 02/29/2020 |
| The reduced expression of Parkin and HtrA2 interpret defective mitophagy leading to clustering of fragmented mitochondria and apoptotic inhibition in scrib knockdown tumors. | scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila.
Yadav AK, Srikrishna S. | 03/9/2019 |
| a Studies indicate a role for Scribble protein during eye and wing development [Review] | Regulation of cellular and PCP signalling by the Scribble polarity module.
Milgrom-Hoffman M, Humbert PO. | 02/2/2019 |
| findings reveal that Scrib's PDZ1 domain functions in the interaction with Gukh and that the Scrib-Gukh interaction has a key role in epithelial tissue development in Drosophila | Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
Caria S, Magtoto CM, Samiei T, Portela M, Lim KYB, How JY, Stewart BZ, Humbert PO, Richardson HE, Kvansakul M., Free PMC Article | 01/19/2019 |
| Data suggest that Nrx-1 plays critical roles in regulating synaptic terminal clustering and release of synaptic vesicles of the neuromuscular junction; Nrx-1 controls terminal clustering and release of synaptic vesicles by stimulating presynaptic actin cytoskeleton assembly; Nrx-1 functions via Scribble and Pixie to activate Rac1. (Nrx-1 = neurexin-1; Rac1 = GTP-binding protein Rac1) | The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering.
Rui M, Qian J, Liu L, Cai Y, Lv H, Han J, Jia Z, Xie W., Free PMC Article | 09/30/2017 |
| the simultaneous loss of the asymmetric cell division regulators Canoe (afadin in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and canoe loss-mediated Ras-PI3K-Akt activation | Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia.
Rives-Quinto N, Franco M, de Torres-Jurado A, Carmena A. | 09/30/2017 |
| the effects of loss of scrib and the modification of these effects via cooperative interactions that enhance the overall tumorigenic potential of scrib deficient cells, is reported. | Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells.
Waghmare I, Kango-Singh M., Free PMC Article | 07/29/2017 |
| Knocking down scribble expression in either Mushroom body neurons or Dopaminergic neurons impairs normal memory loss. | Scribble Scaffolds a Signalosome for Active Forgetting.
Cervantes-Sandoval I, Chakraborty M, MacMullen C, Davis RL., Free PMC Article | 07/1/2017 |
| Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP signaling. Scrib regulates BMP-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 endosomes, where Tkv is active | Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.
Gui J, Huang Y, Shimmi O., Free PMC Article | 05/6/2017 |
| Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo. | The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization.
de Vreede G, Schoenfeld JD, Windler SL, Morrison H, Lu H, Bilder D., Free PMC Article | 09/6/2014 |
| Loss of scrib, dlg and lgl had no effect on gonad formation, but Dlg and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads. | The internal structure of embryonic gonads and testis development in Drosophila melanogaster requires scrib, lgl and dlg activity in the soma.
Papagiannouli F. | 11/16/2013 |
| Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions. | Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity.
Verghese S, Waghmare I, Kwon H, Hanes K, Kango-Singh M., Free PMC Article | 04/27/2013 |
| Loss of Scrib promotes Yorkie/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf signaling. | Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.
Doggett K, Grusche FA, Richardson HE, Brumby AM., Free PMC Article | 02/25/2012 |
| Data show that mutations causing the loss of Salvador (Sav) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules. | Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules.
Zeng X, Singh SR, Hou D, Hou SX., Free PMC Article | 08/23/2010 |
| interaction between Ras(V12) and scrib(-) clones involves JNK signalling propagation and JNK-induced upregulation of JAK/STAT-activating cytokines, a compensatory growth mechanism for tissue homeostasis | Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion.
Wu M, Pastor-Pareja JC, Xu T., Free PMC Article | 02/22/2010 |
| These results demonstrate distinct aPKC and JNK-dependent pathways through which loss of Scrib promotes tumourigenesis in Drosophila. | Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.
Leong GR, Goulding KR, Amin N, Richardson HE, Brumby AM., Free PMC Article | 02/1/2010 |
| Study provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. | Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis.
Li Q, Shen L, Xin T, Xiang W, Chen W, Gao Y, Zhu M, Yu L, Li M., Free PMC Article | 01/21/2010 |