| The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. | The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development.
Rice C, Macdonald SJ, Wang X, Ward RE., Free PMC Article | 07/17/2021 |
| let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State. | let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
Wu YC, Chawla G, Sokol N., Free PMC Article | 07/17/2021 |
| Broad as an important cell-intrinsic transcription factor that promotes the neuroepithelial-cell-to-neuroblast transition. | Broad Promotes Neuroepithelial Stem Cell Differentiation in the Drosophila Optic Lobe.
Zhou Y, Yang Y, Huang Y, Wang H, Wang S, Luo H., Free PMC Article | 04/4/2020 |
| Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors Chinmo and Broad. | Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.
Narbonne-Reveau K, Maurange C., Free PMC Article | 11/30/2019 |
| Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels | Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C.
Hitrik A, Popliker M, Gancz D, Mukamel Z, Lifshitz A, Schwartzman O, Tanay A, Gilboa L., Free PMC Article | 04/29/2017 |
| The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br) that encodes the BR-Z1 transcription factor to activate sens expression | The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence.
Huang YC, Lu YN, Wu JT, Chien CT, Pi H., Free PMC Article | 11/14/2015 |
| Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression. | Early gene Broad complex plays a key role in regulating the immune response triggered by ecdysone in the Malpighian tubules of Drosophila melanogaster.
Verma P, Tapadia MG. | 08/15/2015 |
| broad (br), encoding a small group of zinc-finger transcription factors resulting from alternative splicing, is a transcriptional target of Notch nuclear effector Suppressor of Hairless (Su(H)). | Regulation of broad by the Notch pathway affects timing of follicle cell development.
Jia D, Tamori Y, Pyrowolakis G, Deng WM., Free PMC Article | 08/16/2014 |
| Understanding Broad expression is impossible without simultaneously considering two enhancers, a dynamic gradient, and a network with extracellular and intracellular components. | Dynamic model for the coordination of two enhancers of broad by EGFR signaling.
Cheung LS, Simakov DS, Fuchs A, Pyrowolakis G, Shvartsman SY., Free PMC Article | 01/11/2014 |
| Broad (Br)-mediated hormone signaling regulates AMP specification | Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis.
Zeng X, Hou SX., Free PMC Article | 12/22/2012 |
| analysis of EGFR-dependent network interactions that pattern Drosophila eggshell appendages; each appendage is derived from a primordium comprising a patch of cells expressing broad (br) and an adjacent stripe of cells expressing rhomboid (rho) | EGFR-dependent network interactions that pattern Drosophila eggshell appendages.
Simakov DS, Cheung LS, Pismen LM, Shvartsman SY. | 10/6/2012 |
| These data show the potential for diverse functions of Broad within the developing central nervous system | Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila.
Zhou B, Williams DW, Altman J, Riddiford LM, Truman JW., Free PMC Article | 01/25/2010 |
| cell-type-selective expression of BRC isoforms suggests a model of BRC-dependent CNS morphogenesis resulting from intercellular interactions, culminating in BRC-Z1-controlled, glia-mediated CNS movements in late prepupa. | Broad Complex isoforms have unique distributions during central nervous system metamorphosis in Drosophila melanogaster.
Spokony RF, Restifo LL. | 01/21/2010 |
| Data show that during oogenesis, the two-domain expression pattern of Broad is established by a single gradient of EGFR activation that induces both Broad and Pointed, which mediates repression of Broad. | Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis.
Zartman JJ, Kanodia JS, Cheung LS, Shvartsman SY., Free PMC Article | 01/21/2010 |
| Broad isoform Z1 suppresses Acp65A expression by preventing the normal up-regulation of DHR38 at the time of adult cuticle formation. | Elucidation of the regulation of an adult cuticle gene Acp65A by the transcription factor Broad.
Cui HY, Lestradet M, Bruey-Sedano N, Charles JP, Riddiford LM. | 01/21/2010 |
| PP2A-dependent disruption of centrosome replication and cytoskeleton organization by SV40 small tumor antigen is reported. | PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.
Kotadia S, Kao LR, Comerford SA, Jones RT, Hammer RE, Megraw TL., Free PMC Article | 01/21/2010 |
| Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca. | Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca.
Zhou X, Riddiford LM. | 01/21/2010 |
| depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2, and Z4 first inhibited and then stimulated the process of SG | Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors.
Kuchárová-Mahmood S, Raska I, Mechler BM, Farkas R. | 01/21/2010 |
| The BR-C Z3 isoform is essential for BhC4-1-lacZ induction in prepupal salivary glands and constitute the first demonstration of the participation of early genes products on DNA puff genes regulation. | Broad-Complex, E74, and E75 early genes control DNA puff BhC4-1 expression in prepupal salivary glands.
Basso LR Jr, de C Neves M, Monesi N, Paçó-Larson ML. | 01/21/2010 |
| Mutations in the steroid-regulated genes BR-C and E93 differentially impact larval midgut cell death but do not affect the formation of adult midgut epithelia | Steroid regulation of midgut cell death during Drosophila development.
Lee CY, Cooksey BA, Baehrecke EH. | 01/21/2010 |
| BR-C, the zinc family of transcription factors, is regulated by ecdysone during insect metamorphosis. DRONC caspase is transcriptionally regulated and is essential for ecdysone-mediated cell death. | Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.
Cakouros D, Daish T, Martin D, Baehrecke EH, Kumar S., Free PMC Article | 01/21/2010 |
| Broad-Complex protein is required for Ddc activation at eclosion in Drosophila | Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila.
Chen L, O'Keefe SL, Hodgetts RB. | 01/21/2010 |