| Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion. | Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
Xu M, Wu Z, Li W, Xue L. | 09/20/2024 |
| N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye. | N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
Deshpande P, Chimata AV, Snider E, Singh A, Kango-Singh M, Singh A., Free PMC Article | 08/14/2023 |
| c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD. | c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.
Sahana TG, Chase KJ, Liu F, Lloyd TE, Rossoll W, Zhang K., Free PMC Article | 05/17/2023 |
| Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure. | Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Nandy N, Roy JK. | 03/4/2023 |
| Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells. | Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.
Prasad D, Illek K, Fischer F, Holstein K, Classen AK., Free PMC Article | 02/23/2023 |
| Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways. | Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
Wagner C, Uliczka K, Bossen J, Niu X, Fink C, Thiedmann M, Knop M, Vock C, Abdelsadik A, Zissler UM, Isermann K, Garn H, Pieper M, Wegmann M, Koczulla AR, Vogelmeier CF, Schmidt-Weber CB, Fehrenbach H, König P, Silverman N, Renz H, Pfefferle P, Heine H, Roeder T. | 01/29/2022 |
| JNK Signaling in Drosophila Aging and Longevity. | JNK Signaling in Drosophila Aging and Longevity.
Gan T, Fan L, Zhao L, Misra M, Liu M, Zhang M, Su Y., Free PMC Article | 10/30/2021 |
| Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth. | Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
Zhou J, Valentini E, Boutros M. | 10/23/2021 |
| ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway. | ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
Wei T, Ji X, Gao Y, Zhu X, Xiao G. | 10/16/2021 |
| Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila. | Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.
Sharma V, Mutsuddi M, Mukherjee A. | 07/17/2021 |
| Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. | Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development.
Mok JW, Choi KW., Free PMC Article | 06/12/2021 |
| Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis. | Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis.
Chang YC, Tu H, Huang TW, Xu BW, Pi H., Free PMC Article | 12/12/2020 |
| Snail modulates JNK-mediated cell death in Drosophila. | Snail modulates JNK-mediated cell death in Drosophila.
Wu C, Li Z, Ding X, Guo X, Sun Y, Wang X, Hu Y, Li T, La X, Li J, Li JA, Li W, Xue L., Free PMC Article | 09/5/2020 |
| The authors reveal that transient activation of JNK enhances the expression of the insulin receptor and initiates the insulin-Myc signaling loop to promote mitochondrial respiration and biogenesis by boosting the expression of electron transport chain subunits and of factors essential for mtDNA replication and expression, and for the import of mitochondrial proteins. | Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila.
Wang ZH, Liu Y, Chaitankar V, Pirooznia M, Xu H., Free PMC Article | 03/14/2020 |
| Thus, CtBP stabilizes cell fates following damage by opposing the destabilizing effects of the JNK/AP-1 and JAK/STAT pathways. | CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs.
Worley MI, Alexander LA, Hariharan IK., Free PMC Article | 08/10/2019 |
| JNK and Yorkie cooperatively drive tumor progression by generating oncogenic polyploid giant cells. | JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila.
Cong B, Ohsawa S, Igaki T. | 03/9/2019 |
| provide a mechanism to explain how an ATF3-Raw module controls JNK signalling to maintain normal intestinal barrier function during acute infection | ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration.
Zhou J, Edgar BA, Boutros M., Free PMC Article | 12/22/2018 |
| Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK/STAT activation was suppressed by fusion-inducing JNK signaling. | Spatiotemporal regulation of cell fusion by JNK and JAK/STAT signaling during Drosophila wound healing.
Lee JH, Lee CW, Park SH, Choe KM. | 03/17/2018 |
| aken together, these results reveal that inactivation of Rpd3 independently regulates JNK and Yki activities and that both Hippo and JNK signaling pathways contribute to Rpd3 RNAi-induced apoptosis. | Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling.
Zhang T, Sheng Z, Du W., Free PMC Article | 12/30/2017 |
| Increased expression of the Drosophila JNK basket in the setting of reduced cindr expression was found to result in even more severe apoptosis, whilst ectopic death was found to be reduced if retinas were heterozygous for basket. | JNK is antagonized to ensure the correct number of interommatidial cells pattern the Drosophila retina.
Bushnell HL, Feiler CE, Ketosugbo KF, Hellerman MB, Nazzaro VL, Johnson RI., Free PMC Article | 12/23/2017 |
| Data show that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation. | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.
Kucinski I, Dinan M, Kolahgar G, Piddini E., Free PMC Article | 11/18/2017 |
| Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling | Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.
Kushnir T, Mezuman S, Bar-Cohen S, Lange R, Paroush Z, Helman A., Free PMC Article | 07/22/2017 |
| n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing | Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.
Rousset R, Carballès F, Parassol N, Schaub S, Cérézo D, Noselli S., Free PMC Article | 05/27/2017 |
| malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase. | Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
Külshammer E, Mundorf J, Kilinc M, Frommolt P, Wagle P, Uhlirova M., Free PMC Article | 07/30/2016 |
| Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction. | Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction.
Wong CO, Palmieri M, Li J, Akhmedov D, Chao Y, Broadhead GT, Zhu MX, Berdeaux R, Collins CA, Sardiello M, Venkatachalam K., Free PMC Article | 07/16/2016 |