| Regulation of endogenous retrovirus-derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells. | Regulation of endogenous retrovirus-derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells.
Du C, Jiang J, Li Y, Yu M, Jin J, Chen S, Fan H, Macfarlan TS, Cao B, Sun MA., Free PMC Article | 03/8/2023 |
| Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis. | Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis.
Stec M, Seweryn M, Korkosz M, Guła Z, Szatanek R, Węglarczyk K, Rutkowska-Zapała M, Lenart M, Czepiel M, Czyż J, Baran J, Gruca A, Wojnar-Lasoń K, Wołkow P, Siedlar M., Free PMC Article | 10/30/2021 |
| MSX2 suppression through inhibition of TGFbeta signaling enhances hematopoietic differentiation of human embryonic stem cells. | MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells.
Wang H, Wang M, Wang Y, Wen Y, Chen X, Wu D, Su P, Zhou W, Shi L, Zhou J., Free PMC Article | 07/31/2021 |
| A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma. | A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.
Szemes M, Melegh Z, Bellamy J, Greenhough A, Kollareddy M, Catchpoole D, Malik K., Free PMC Article | 02/13/2021 |
| Induced pluripotent stem cell-derived mesenchymal stromal cells (iMSCs) are functionally and genetically different from bone marrow-derived mesenchymal stromal cells (BM-MSCs): iMSCs express very high levels of both KDR and MSX2 compared with BM-MSCs, while BM-MSCs had significantly higher levels of PDGFRalpha. | Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells Are Functionally and Genetically Different From Bone Marrow-Derived Mesenchymal Stromal Cells.
Xu M, Shaw G, Murphy M, Barry F., Free PMC Article | 05/2/2020 |
| Low MSX2 expression is associated with drug resistance in lung cancer. | The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells.
Yin Y, Xie CM, Li H, Tan M, Chen G, Schiff R, Xiong X, Sun Y., Free PMC Article | 04/4/2020 |
| The extent of calcification correlated positively with the flow velocity, as did the mRNA and protein levels of TGF-beta1, BMP2, and MSX2. These findings indicate that TGF-beta1/BMP2 signaling is involved in valve calcification induced by abnormal mechanical stimulation. | Role of TGF-β1 Signaling in Heart Valve Calcification Induced by Abnormal Mechanical Stimulation in a Tissue Engineering Model.
Hu XJ, Wu WC, Dong NG, Shi JW, Liu JW, Chen S, Deng C, Shi F. | 01/26/2019 |
| p19(INK4d) plays an active role during human tooth development along with MSX1 and MSX2 | Regulation of proliferation in developing human tooth germs by MSX homeodomain proteins and cyclin-dependent kinase inhibitor p19(INK4d).
Kero D, Vukojevic K, Stazic P, Sundov D, Mardesic Brakus S, Saraga-Babic M., Free PMC Article | 07/14/2018 |
| MSX2 might be a new drug resistance related gene in pancreatic cancer cells by up-regulation of MRP2 expression. | [A novel chemo-resistant gene MSX2 discovered by establishment of two pancreatic cancer drug resistant cell lines JF305/CDDP and PANC-1/GEM].
Yuan W, Sui CG, Ma X, Ma J. | 07/7/2018 |
| MSX2 played a crucial role in the progression of colorectal cancer and may be a potential novel prognostic factor | Prognostic Relevance and Function of MSX2 in Colorectal Cancer.
Liu J, An H, Yuan W, Feng Q, Chen L, Ma J., Free PMC Article | 06/24/2017 |
| MSX2 protein expression is downregulated in placental villi from Pre-Eclampsia. | MSX2 Induces Trophoblast Invasion in Human Placenta.
Liang H, Zhang Q, Lu J, Yang G, Tian N, Wang X, Tan Y, Tan D., Free PMC Article | 09/3/2016 |
| The MSX2 destabilizes the pluripotency circuitry through direct binding to the SOX2 promoter, while MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression. | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling.
Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Feng S, Han M, Xu Y, Wang F, Zhou J., Free PMC Article | 08/20/2016 |
| This is the first report of an eye development defect due to an increase in the MSX2 copy number in a human being. | MSX2 Gene Duplication in a Patient with Eye Development Defects.
Plaisancié J, Collet C, Pelletier V, Perdomo Y, Studer F, Fradin M, Schaefer E, Speeg-Schatz C, Bloch-Zupan A, Flori E, Dollfus H. | 07/30/2016 |
| SLUG and MSX2, transcription factors involved in epithelial-mesenchymal transitions, essential features of gastrulation in development and tumor progression, are important mediators of BMP4-induced differentiation in human embryonic stem cells. | BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.
Richter A, Valdimarsdottir L, Hrafnkelsdottir HE, Runarsson JF, Omarsdottir AR, Ward-van Oostwaard D, Mummery C, Valdimarsdottir G. | 10/11/2014 |
| These data confirm that missense mutations altering the proline at codon 148 of MSX2 cause dominantly inherited craniosynostosis. | Boston type craniosynostosis: report of a second mutation in MSX2.
Florisson JM, Verkerk AJ, Huigh D, Hoogeboom AJ, Swagemakers S, Kremer A, Heijsman D, Lequin MH, Mathijssen IM, van der Spek PJ. | 05/17/2014 |
| PKC signaling modulates osteoblast differentiation, at least in part, through the regulation of Msx2. | PKC signaling inhibits osteogenic differentiation through the regulation of Msx2 function.
Jeong HM, Jin YH, Choi YH, Yum J, Choi JK, Yeo CY, Lee KY. | 02/23/2013 |
| Msx2 and topo II-alpha may play an important role in the occurrence and development of sinonasal inverted papilloma. | [Expression and significance of Msx2 and topo II-alpha in sinonasal inverted papilloma].
Wu Q, Yang Y, Wu X, Zhao C, Cong L, Ruan B, Zhang J. | 02/9/2013 |
| The pathogenic effect of the microduplications can best be explained by a misregulation of spatiotemporal MSX2 expression patterns in cleidocranial dysplasia. | Microduplications upstream of MSX2 are associated with a phenocopy of cleidocranial dysplasia.
Ott CE, Hein H, Lohan S, Hoogeboom J, Foulds N, Grünhagen J, Stricker S, Villavicencio-Lorini P, Klopocki E, Mundlos S. | 01/12/2013 |
| Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression. | [Changes in the expression of Dlx5, Msx2, and Dlx5/Msx2 in hPDLSCs loaded with cyclic tensile stress].
Sun CX, Zhang LK, Feng XX, Zhao ZH. | 08/11/2012 |
| The detailed regulatory mechanism of ABCG2 expression by MSX2 in pancreatic cancer cells was investigated. | The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2.
Hamada S, Satoh K, Hirota M, Kanno A, Umino J, Ito H, Masamune A, Kikuta K, Kume K, Shimosegawa T. | 02/4/2012 |
| activation of RAGE not only inhibits myocardin-dependent SMC gene expression, but also induces osteogenic differentiation of vascular SMC through Notch/Msx2 induction | Activation of receptor for advanced glycation end products induces osteogenic differentiation of vascular smooth muscle cells.
Suga T, Iso T, Shimizu T, Tanaka T, Yamagishi S, Takeuchi M, Imaizumi T, Kurabayashi M. | 01/7/2012 |
| findings indicate MSX2 is a direct downstream transcriptional target of beta-catenin/TCF and has a key contributing role in the cancer phenotype of OEAs carrying WNT/beta-catenin pathway defects | MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.
Zhai Y, Iura A, Yeasmin S, Wiese AB, Wu R, Feng Y, Fearon ER, Cho KR., Free PMC Article | 11/26/2011 |
| MSX2 may be an important regulator of melanoma cell invasion and survival. Cytoplasmic expression of the protein was identified as biomarker for good prognosis in malignant melanoma. | Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma.
Gremel G, Ryan D, Rafferty M, Lanigan F, Hegarty S, Lavelle M, Murphy I, Unwin L, Joyce C, Faller W, McDermott EW, Sheahan K, Ponten F, Gallagher WM., Free PMC Article | 10/1/2011 |
| Notch1 intracellular domain.RBPJk complex enhances the BMP2-induced Msx2 gene expression by cooperating with Smad1 and suggest that Notch signaling makes vascular SMC responsive to BMP2 and promotes vascular calcification. | Notch signaling pathway enhances bone morphogenetic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells.
Shimizu T, Tanaka T, Iso T, Matsui H, Ooyama Y, Kawai-Kowase K, Arai M, Kurabayashi M., Free PMC Article | 07/30/2011 |
| Maternal Msx2 C386T gene polymorphisms were associated with fetal neural tube defects in Han Chinese women in Shanxi Province. | Single nucleotide polymorphisms of the maternal Msx2 gene and their association with fetal neural tube defects in Han ethnic group in Shanxi Province, China.
Guo L, Zhao H, Pei YH, He QR, Li WI, Zhang T, Zheng XY, Zhou R, Xie J. | 06/25/2011 |