| Spinocerebellar ataxia type 4 is caused by a GGC expansion in the ZFHX3 gene and is associated with prominent dysautonomia and motor neuron signs. | Spinocerebellar ataxia type 4 is caused by a GGC expansion in the ZFHX3 gene and is associated with prominent dysautonomia and motor neuron signs.
Paucar M, Nilsson D, Engvall M, Laffita-Mesa J, Söderhäll C, Skorpil M, Halldin C, Fazio P, Lagerstedt-Robinson K, Solders G, Angeria M, Varrone A, Risling M, Jiao H, Nennesmo I, Wedell A, Svenningsson P. | 10/3/2024 |
| ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favourable outcomes. | ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favourable outcomes.
He MF, Liu LH, Luo S, Wang J, Guo JJ, Wang PY, Zhai QX, He SL, Zou DF, Liu XR, Li BM, Ma HY, Qiao JD, Zhou P, He N, Yi YH, Liao WP., Free PMC Article | 07/2/2024 |
| Adaptive Long-Read Sequencing Reveals GGC Repeat Expansion in ZFHX3 Associated with Spinocerebellar Ataxia Type 4. | Adaptive Long-Read Sequencing Reveals GGC Repeat Expansion in ZFHX3 Associated with Spinocerebellar Ataxia Type 4.
Chen Z, Gustavsson EK, Macpherson H, Anderson C, Clarkson C, Rocca C, Self E, Alvarez Jerez P, Scardamaglia A, Pellerin D, Montgomery K, Lee J, Gagliardi D, Luo H, Genomics England Research Consortium, Hardy J, Polke J, Singleton AB, Blauwendraat C, Mathews KD, Tucci A, Fu YH, Houlden H, Ryten M, Ptáček LJ. | 03/26/2024 |
| Haploinsufficiency of ZFHX3, encoding a key player in neuronal development, causes syndromic intellectual disability. | Haploinsufficiency of ZFHX3, encoding a key player in neuronal development, causes syndromic intellectual disability.
Pérez Baca MDR, Jacobs EZ, Vantomme L, Leblanc P, Bogaert E, Dheedene A, De Cock L, Haghshenas S, Foroutan A, Levy MA, Kerkhof J, McConkey H, Chen CA, Batzir NA, Wang X, Palomares M, Carels M, ZFHX3 consortium, Dermaut B, Sadikovic B, Menten B, Yuan B, Vergult S, Callewaert B., Free PMC Article | 03/11/2024 |
| Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus. | Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus.
Casalino-Matsuda SM, Chen F, Gonzalez-Gonzalez FJ, Matsuda H, Nair A, Abdala-Valencia H, Budinger GRS, Dong JT, Beitel GJ, Sporn PH., Free PMC Article | 02/24/2024 |
| Exonic trinucleotide repeat expansions in ZFHX3 cause spinocerebellar ataxia type 4: A poly-glycine disease. | Exonic trinucleotide repeat expansions in ZFHX3 cause spinocerebellar ataxia type 4: A poly-glycine disease.
Wallenius J, Kafantari E, Jhaveri E, Gorcenco S, Ameur A, Karremo C, Dobloug S, Karrman K, de Koning T, Ilinca A, Landqvist Waldö M, Arvidsson A, Persson S, Englund E, Ehrencrona H, Puschmann A., Free PMC Article | 01/8/2024 |
| Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias. | Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias.
Jameson HS, Hanley A, Hill MC, Xiao L, Ye J, Bapat A, Ronzier E, Hall AW, Hucker WJ, Clauss S, Barazza M, Silber E, Mina JA, Tucker NR, Mills RW, Dong JT, Milan DJ, Ellinor PT., Free PMC Article | 08/7/2023 |
| Influence of ZFHX3 Polymorphisms on the Risk of Ischemic Stroke in Chinese Han Population. | Influence of ZFHX3 Polymorphisms on the Risk of Ischemic Stroke in Chinese Han Population.
Hu W, Wang G, Wang P, Jin H, Liu J, Dang X. | 02/27/2023 |
| Inactivation of PTEN and ZFHX3 in Mammary Epithelial Cells Alters Patterns of Collective Cell Migration. | Inactivation of PTEN and ZFHX3 in Mammary Epithelial Cells Alters Patterns of Collective Cell Migration.
Dayoub A, Fokin AI, Lomakina ME, James J, Plays M, Jacquin T, Novikov NM, Vorobyov RS, Schegoleva AA, Rysenkova KD, Gaboriaud J, Leonov SV, Denisov EV, Gautreau AM, Alexandrova AY., Free PMC Article | 01/14/2023 |
| ATBF1 is a potential diagnostic marker of histological grade and functions via WNT5A in breast cancer. | ATBF1 is a potential diagnostic marker of histological grade and functions via WNT5A in breast cancer.
Li M, Zheng Y, Li X, Shen X, Zhang T, Weng B, Mao H, Zhao J., Free PMC Article | 12/17/2022 |
| Association between the rs2106261 polymorphism in the zinc finger homeobox 3 gene and risk of atrial fibrillation: Evidence from a PRISMA-compliant meta-analysis. | Association between the rs2106261 polymorphism in the zinc finger homeobox 3 gene and risk of atrial fibrillation: Evidence from a PRISMA-compliant meta-analysis.
Wei Y, Wang L, Lin C, Xie Y, Bao Y, Luo Q, Zhang N., Free PMC Article | 04/23/2022 |
| AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells. | AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells.
Fu X, Zhang Z, Liu M, Li J, A J, Fu L, Huang C, Dong JT., Free PMC Article | 04/9/2022 |
| Prognostic effect of coexisting TP53 and ZFHX3 mutations in non-small cell lung cancer patients treated with immune checkpoint inhibitors. | Prognostic effect of coexisting TP53 and ZFHX3 mutations in non-small cell lung cancer patients treated with immune checkpoint inhibitors.
Zhang L, Zhang T, Shang B, Li Y, Cao Z, Wang H. | 03/12/2022 |
| Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression. | Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression.
Zhan X, Zhao A., Free PMC Article | 11/6/2021 |
| ZFHX3 knockdown dysregulates mitochondrial adaptations to tachypacing in atrial myocytes through enhanced oxidative stress and calcium overload. | ZFHX3 knockdown dysregulates mitochondrial adaptations to tachypacing in atrial myocytes through enhanced oxidative stress and calcium overload.
Lkhagva B, Lin YK, Chen YC, Cheng WL, Higa S, Kao YH, Chen YJ. | 09/4/2021 |
| ATBF1 Participates in Dual Functions of TGF-beta via Regulation of Gene Expression and Protein Translocalization. | ATBF1 Participates in Dual Functions of TGF-β via Regulation of Gene Expression and Protein Translocalization.
Li M, Zhang A, Zheng Y, Li J, Zhao J., Free PMC Article | 04/3/2021 |
| ZFHX3 mutation as a protective biomarker for immune checkpoint blockade in non-small cell lung cancer. | ZFHX3 mutation as a protective biomarker for immune checkpoint blockade in non-small cell lung cancer.
Zhang J, Zhou N, Lin A, Luo P, Chen X, Deng H, Kang S, Guo L, Zhu W, Zhang J., Free PMC Article | 02/2/2021 |
| The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1alpha in liver cancer cells. | The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells.
Fu C, An N, Liu J, A J, Zhang B, Liu M, Zhang Z, Fu L, Tian X, Wang D, Dong JT., Free PMC Article | 12/26/2020 |
| SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation. | SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
Wu R, Fang J, Liu M, A J, Liu J, Chen W, Li J, Ma G, Zhang Z, Zhang B, Fu L, Dong JT., Free PMC Article | 12/26/2020 |
| The ZFHX3 plays an important role in intracellular calcium homeostasis in mammary epithelial cells, at least in part, by regulating TRPV6. | Transcription factor ZFHX3 regulates calcium influx in mammary epithelial cells in part via the TRPV6 calcium channel.
Zhao D, Han X, Huang L, Wang J, Zhang X, Jeon JH, Zhao Q, Dong JT. | 07/4/2020 |
| The ZFHX3 SNP rs2106261 minor allele is associated with lower atrial fibrillation (AF) recurrence rate after pulmonary vein isolation. Low baseline inflammation conferred by this allele may reduce AF recurrence risk. | Maintenance of low inflammation level by the ZFHX3 SNP rs2106261 minor allele contributes to reduced atrial fibrillation recurrence after pulmonary vein isolation.
Tomomori S, Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Motoda C, Matsumura H, Amioka M, Hironobe N, Ookubo Y, Okamura S, Kawazoe H, Chayama K, Kihara Y., Free PMC Article | 03/2/2019 |
| alterations in the expression and subcellular localization of ATBF1, as a result of posttranscriptional modifications, are associated with malignant features of colon tumours. | Expression and subcellular localization of AT motif binding factor 1 in colon tumours.
Kataoka H, Miura Y, Kawaguchi M, Suzuki S, Okamoto Y, Ozeki K, Shimura T, Mizoshita T, Kubota E, Tanida S, Takahashi S, Asai K, Joh T., Free PMC Article | 04/21/2018 |
| Study identified DNA methylation (DNAm) site cg07786668 in ZFHX3 that is independently and significantly associated with myocardial infarction (MI) along with DNAm cg17218495 in SMARCA4. These results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by cardiovascular disease-associated SNPs in these genes. | Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.
Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M., Free PMC Article | 03/17/2018 |
| using in vitro prolactin induced lactogenic differentiation in an HC11 mouse cell model and an in vivo conditional knockout mouse model we showed that mouse Zfhx3 is essential for mouse mammary epithelial cell differentiation and mouse mammary gland development at the lactation stage through regulation of prolactin receptor expression and the downstream Jak2-Stat5 signaling pathway. | Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity.
Zhao D, Ma G, Zhang X, He Y, Li M, Han X, Fu L, Dong XY, Nagy T, Zhao Q, Fu L, Dong JT., Free PMC Article | 01/10/2018 |
| Increasing experimental data support that ZFHX3 gene plays a critical role in the pathogenesis of atrial fibrillation where it was found up-regulated. [review] | The unrecognized role of tumor suppressor genes in atrial fibrillation.
Mao L, Huang W, Zou P, Dang X, Zeng X. | 12/23/2017 |