| Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer. | Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.
Papakyriacou I, Kutkaite G, Rúbies Bedós M, Nagarajan D, Alford LP, Menden MP, Mao Y., Free PMC Article | 05/21/2024 |
| Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review). | Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
Wang T, Li X, Ma R, Sun J, Huang S, Sun Z, Wang M., Free PMC Article | 03/25/2024 |
| [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps]. | [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
Meng C, Yan B, Huang Y, Wang C, Zhang L., Free PMC Article | 11/1/2023 |
| Blocking neddylation elicits antiviral effect against hepatitis B virus replication. | Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
Abounouh K, Kayesh MEH, Altawalah H, Kitab B, Murakami S, Ogawa S, Tanaka Y, Dehbi H, Pineau P, Kohara M, Benjelloun S, Tsukiyama-Kohara K, Ezzikouri S. | 03/26/2022 |
| The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases. | The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA., Free PMC Article | 03/19/2022 |
| The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage. | The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
Bailly AP, Xirodimas DP. | 02/5/2022 |
| A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1). | A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
Zhang Z, Zhang J, Tian J, Li H., Free PMC Article | 02/5/2022 |
| Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation. | Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
Bravo-Navas S, Yáñez L, Romón Í, Briz M, Domínguez-García JJ, Pipaón C., Free PMC Article | 01/29/2022 |
| Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation. | Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
Lobato-Gil S, Heidelberger JB, Maghames C, Bailly A, Brunello L, Rodriguez MS, Beli P, Xirodimas DP. | 01/29/2022 |
| Structural and functional consequences of NEDD8 phosphorylation. | Structural and functional consequences of NEDD8 phosphorylation.
Stuber K, Schneider T, Werner J, Kovermann M, Marx A, Scheffner M., Free PMC Article | 11/6/2021 |
| TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia. | TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Ochiiwa H, Ailiken G, Yokoyama M, Yamagata K, Nagano H, Yoshimura C, Muraoka H, Ishida K, Haruma T, Nakayama A, Hashimoto N, Murata K, Nishimura M, Kawashima Y, Ohara O, Ohkubo S, Tanaka T., Free PMC Article | 07/31/2021 |
| Neddylation blockade induces HIF-1alpha driven cancer cell migration via upregulation of ZEB1. | Neddylation blockade induces HIF-1α driven cancer cell migration via upregulation of ZEB1.
Park JB, Seo J, Park JW, Chun YS., Free PMC Article | 05/15/2021 |
| Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. | Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA., Free PMC Article | 04/3/2021 |
| HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response. | HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.
Guo Z, Wang S, Xie Y, Han Y, Hu S, Guan H, Xie D, Bai C, Liu X, Gu Y, Zhou PK, Ma T., Free PMC Article | 03/13/2021 |
| Neddylation promotes protein translocation between the cytoplasm and nucleus. | Neddylation promotes protein translocation between the cytoplasm and nucleus.
Li S, Fang W, Cui Y, Shi H, Chen J, Li L, Zhang L, Zhang X. | 02/13/2021 |
| The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. | The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.
Bailly AP, Perrin A, Serrano-Macia M, Maghames C, Leidecker O, Trauchessec H, Martinez-Chantar ML, Gartner A, Xirodimas DP., Free PMC Article | 09/19/2020 |
| We present here the first evidence that the neuroinflammatory mediator IL-1beta facilitates ubiquitin ligase parkin/NEDD8 interactions | Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.
Balasubramaniam M, Parcon PA, Bose C, Liu L, Jones RA, Farlow MR, Mrak RE, Barger SW, Griffin WST., Free PMC Article | 07/18/2020 |
| NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA., Free PMC Article | 05/30/2020 |
| The present study was designed to assess the effects of Nedd8conjugating enzyme UBE2M knockdown on intrahepatic cholangiocarcinoma cells, and to determine the potential underlying mechanisms. UBE2M and associated protein expression levels were determined via immunohistochemistry and western blotting | Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
Zhao B, Gao C, Shi D, Mao J, Zhao J, Guo L, Guo J, Jiao Z. | 04/4/2020 |
| neddylation pathway promotes CCL2 transactivation and tumor-associated macrophages infiltration in lung cancer to provide a tumor-promoting microenvironment | Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer.
Zhou L, Jiang Y, Liu X, Li L, Yang X, Dong C, Liu X, Lin Y, Li Y, Yu J, He R, Huang S, Liu G, Zhang Y, Jeong LS, Hoffman RM, Jia L. | 02/29/2020 |
| In this study, we found that UBC12 was overexpressed in human lung cancer, increased with disease deterioration, and positively correlated with NEDD8 expression. Moreover, targeting UBC12 effectively suppressed the malignant phenotypes of lung cancer both in vitro and in vivo | Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer.
Li L, Kang J, Zhang W, Cai L, Wang S, Liang Y, Jiang Y, Liu X, Zhang Y, Ruan H, Chen G, Wang M, Jia L., Free PMC Article | 01/11/2020 |
| Study shows that Cullin-RING Ligase-2 (CRL2) activates CSN5/CSN6 in a neddylation-independent manner. The presence of NEDD8 is required to activate the CSN5 active site. Synergising cryo-electron microscopy with mass spectrometry, study identified sensory regions of the COP9 signalosome that mediate its stepwise activation and provide a framework for understanding the regulatory mechanism of other Cullin family members. | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A., Free PMC Article | 12/28/2019 |
| RAD18 is a target of NEDD8, an ubiquitin-like protein. | NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage.
Guan J, Zheng X. | 09/14/2019 |
| it was demonstrated that high expression of neddylation components, neural precursor cell expressed, developmentally downregulated 8 (NEDD8) and NEDD8activating enzyme 1 (NAE1), were associated with poor survival of patients with hepatocellular carcinoma (HCC) | Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib.
Yang Z, Zhang J, Lin X, Wu D, Li G, Zhong C, Fang L, Jiang P, Yin L, Zhang L, Bie P, Xie CM., Free PMC Article | 08/17/2019 |
| The newly identified CUBAN (Cullin binding domain associating with NEDD8) domain recognizes both ubiquitin and the ubiquitin-like NEDD8. After a slow conformational selection step, hydrophobic and then neutral and polar interactions take place, which drive the correct orientation of the CUBAN domain, leading to differences in the recognition scheme of NEDD8 and ubiquitin. | CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8.
Santonico E, Nepravishta R, Mandaliti W, Castagnoli L, Cesareni G, Paci M., Free PMC Article | 06/29/2019 |